Coexpression of Bcl-2, c-Myc, and p53 oncoproteins as prognostic discriminants in patients with colorectal carcinoma

Lanepitant is a high-affinity, selective neurokinin-1 receptor (NK-1) and is effective in the dural inflammation model of acute migraine. Lanepitant 30, 80, and 240 mg given orally was evaluated in a double-blind, placebo-controlled crossover study to determine its effect in reducing migraine pain and severity of associated symptoms. Outpatients treated four migraine headaches of moderate or severe pain intensity with study drug according to a randomization schedule. They recorded their pain intensity and severity of migraine-associated symptoms at 30, 60, 90, and 120 min. Although 53 patients were randomly allocated to a treatment sequence, only 40 patients completed all treatments. There was no statistically significant difference in improvement in migraine pain at any time for any of the treatments. Additionally, there was no change in severity of migraine-associated symptoms associated with lanepitant therapy. No adverse events could be attributed to lanepitant. Lanepitant was ineffective orally in treating acute migraine in this trial. This may be due to poor bioavailability during a migraine attack. Alternatively, the neurogenic inflammation hypothesis may not apply to migraine.     

Characterization of unconventional MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice

Deafness is the most common form of sensory impairment in humans. Mutations in unconventional myosins have been found to cause deafness in humans and mice. The mouse recessive deafness mutation, Snell's waltzer, contains an intragenic deletion in an unconventional myosin, myosin VI (locus designation, Myo6). The requirement for Myo6 for proper hearing in mice makes this gene an excellent candidate for a human deafness disorder. Here we report the cloning and characterization of the human unconventional myosin VI (locus designation, MYO6) cDNA. The MYO6 gene maps to human chromosome 6q13. The isolation of the human gene makes it now possible to determine if mutations in MYO6 contribute to the pathogenesis of deafness in the human population.     

Effect of Compressive Deformation on Lenticular and Thin Plate Martensitic Transformations

The effect of compressive deformation testedabove the M_s temperature on the martensitemorphology in Fe-Ni-C alloys has been studied.Inthe Fe-30Ni-0.12C alloy,the M_s temperature is-50℃ The cylindrical specimens werecompressively deformed at -40℃.The strain rateswere 10,20,30 and 40%.X-ray analysis andmetallographic examination showed that nostrain-induced martensite was found.After quench-ing to -53℃,some thin plates and unusualmorphologies of lenticular martensites with bentand/or broken mid-ribs were observed.In theFe-30Ni-0.34C alloy,the M_s temperature is-120℃.Compressive deformation with differentstrain rates were carried out at room temperature.After quenching to the liquid nitrogen temperature,some bent thin plate matensites(unbroken)occur-red.The transformed twins in bent plate were alsobent and nearly parallel to the γ-α'interfaces.Orientation relationship between austenite and bentmartensite has been examined by means of trans-mission electron microscope.It was proved thatthese unusual morphologies are inherent in thecompressive pre-deformed austenite.     

Effect of pH on Formation, Proximate Composition and Rehydration Capacity of Winged Bean and Soybean Protein-Lipid Film

The effect of various pHs on winged bean and soybean protein-lipid films formation, proximate composition and rehydration capacity were studied. Film can only form within a specific range of pH. Films prepared at high pHs (7.5, 9.0, 10.0 and 11.0) contained higher proportions of proteins, ash and carbohydrate but lower proportion of fat than those at pH 6.7, 2.5 and 2.0. Winged bean and soybean films were found to have different pattern of rehydration, however both tended to absorb more water at high pH. With regard to film formation efficiency, nutritional value (higher protein content) and rehydration capacity, soybean film is better than winged bean film.     

环保型固体文具胶的制备

以聚醋酸乙烯、聚乙烯醇、硬脂酸钠、甘油、乙二醇等为原料，制得一系列固体胶棒。通过对其粘性、涂希l生、赋形性等使用性能测试比较，得出了一种环保型固体文具胶最佳配方。探讨了凝胶剂、胶粘剂、改性助剂、保湿剂、溶剂等组份对固体文具胶使用性能的影响。研究结果表明：聚醋酸乙烯乳液和聚乙烯醇共混改性生产固体文具胶，原料均环保无污染，且全部转化为产品，无三废生成。在最佳工艺条件下生产的产品，具有赋形性好，初始粘性强，粘接强度高，涂布性能好，适应温度范围宽，成本低，无毒的特点。     

工业废渣-盾构泥砂注浆材料的研制与应用

以水玻璃作激发剂,磷石膏、粉煤灰、钢渣与矿粉作胶凝材料,盾构泥砂为细集料,并用聚羧酸系抗泥型高效减水剂和抗水分散剂改善浆料性能;通过对粉料比例、激发剂掺量等的研究,制得工作性能好(初始流动度27cm、6h后23.5cm,3h泌水率1%),凝结时间长(60h),抗水分散(水陆强度比85%),可防止管片上浮(稠度值11.3cm)的高性能工业废渣-盾构泥砂同步注浆材料,并在武汉轨道交通3号线八B标段双王区间站取得了成功应用。     

颗粒图像测速技术在离心试验变形分析中的应用

由于颗粒图像测速技术的可遥控性和实时性,可用于离心机试验中进行土体变形测量.将土体划分为若干细小单元,通过单元的颗粒组成纹理,可以追踪单元的位移,从而确定土体的变形.以此为依据,建立一套系统来实现离心机试验中土体模型的变形监测,包括高分辨率数码相机、精确控制点、土体可识别纹理.试验后对系列图片进行数字化处理,并对实验中产生的各种误差加以修正,得到需要的变形数据.基于测速技术原理的分析,该系统的位移测量精度可以达到0.04 mm,准确度0.02 mm左右.在砂土边坡的离心试验中应用该系统,分别量测模型边坡在离心加速度增加过程中产生的变形和地下水上升过程中渗流引起的变形,试验结果规律性好,可以反映模型土体各个位置不同时刻的位移情况.表明该系统适用于离心环境中的模型试验,是研究其完整物理过程的重要工具.     

关于对建筑工程质量检测管理改革的探讨(一)

结合对各地的建筑工程质量检测管理的调研,对我国建设工程检测管理体系的建立、工程检测技术的发展,以及工程检测在保证建设工程质量中的作用等进行了总结回顾;对目前建设工程检测行业的管理现状以及不足进行了分析,并提出了完善检测管理工作的建议。