Determining Geographic Vulnerabilities Using a Novel Impact Based Resilience Metric

Various natural and man-made disasters as well as major political events (like riots) have increased the importance of understanding geographic failures and how correlated failures impact networks. Since mission critical networks are overlaid as virtual networks over a physical network infrastructure forming multilayer networks, there is an increasing need for methods to analyze multilayer networks for geographic vulnerabilities. In this paper, we present a novel impact-based resilience metric. Our new metric uses ideas borrowed from performability to combine network impact with state probability to calculate a new metric called Network Impact Resilience. The idea is that the highest impact to the mission of a network should drive its resilience metric. Furthermore, we present a state space analysis method that analyzes multilayer networks for geographic vulnerabilities. To demonstrate the methods, the inability to provision a given number of upper layer services is used as the criteria for network failure. Mapping techniques for multilayer network states are presented. Simplifying geographic state mapping techniques to reduce enumeration costs are also presented and tested. Finally, these techniques are tested on networks of varying sizes.     

Survey of control performance in quantum information processing

There is a rich variety of physics underlying the fundamental gating operations for quantum information processing (QIP). A key aspect of a QIP system is how noise may enter during quantum operations and how suppressing or correcting its effects can best be addressed. Quantum control techniques have been developed to specifically address this effort, although a detailed classification of the compatibility of controls schemes with noise sources found in common quantum systems has not yet been performed. This work numerically examines the performance of modern control methods for suppressing decoherence in the presence of noise forms found in viable quantum systems. The noise-averaged process matrix for controlled one-qubit and two-qubit operations are calculated across noise found in systems driven by Markovian open quantum dynamics. Rather than aiming to describe the absolute best control scheme for a given physical circumstance, this work serves instead to classify quantum control behavior across a large class of noise forms so that opportunities for improving QIP performance may be identified.     

Color Subspaces as Photometric Invariants

Complex reflectance phenomena such as specular reflections confound many vision problems since they produce image ‘features’ that do not correspond directly to intrinsic surface properties such as shape and spectral reflectance. A common approach to mitigate these effects is to explore functions of an image that are invariant to these photometric events. In this paper we describe a class of such invariants that result from exploiting color information in images of dichromatic surfaces. These invariants are derived from illuminant-dependent ‘subspaces’ of RGB color space, and they enable the application of Lambertian-based vision techniques to a broad class of specular, non-Lambertian scenes. Using implementations of recent algorithms taken from the literature, we demonstrate the practical utility of these invariants for a wide variety of applications, including stereo, shape from shading, photometric stereo, material-based segmentation, and motion estimation.     

IT Is Here to Serve

By having IT address itself instead of the business and its customers, we've seen IT projects emerge that have no business value, creating the public perception of IT as a black hole of funding. This black-hole perception magnifies when the IT department doesn't partner with company stakeholders when addressing actual needs; rather, IT professionals create solutions based on what they want to provide instead of what the business requires. The author describes why it's essential for IT professionals to turn outward rather than inward.     

Percentages of cervical cytologic diagnoses as a quality assurance method

OBJECTIVE: To demonstrate empirically that the efficiency of rescreening to discover false negative cytologic diagnoses is greatly enhanced by prospectively stratifying accessions according to risk level. STUDY DESIGN: We stratified accessions from 11 clinical sources and established the rate of diagnoses according to three categories: (1) "within normal limits"/"benign cellular changes" (WNL/BCC), (2) "atypical squamous/glandular cells of undetermined significance" (ASCUS/AGCUS) and (3) "squamous intraepithelial lesion/invasive carcinoma" (SIL/CA). We then prospectively rescreened all negative smears from sources with rates of positive diagnoses (ASCUS/AGCUS and SIL/CA) in excess of 20% and 5% of negative smears from sources with rates of positive diagnoses < 20%. We compared the detection rates of false negatives on rescreening target groups with random rescreening of 10% of all negative smears. RESULTS: The rates of SIL/CA, ASCUS/AGCUS and WNL/BCC varied from 0 to 43%, 4% to 14% and 46% to 94%, respectively. Rescreening 10% of all negative smears revealed a false negative fraction of 3%; rescreening target groups revealed a false negative fraction of 5.9%. CONCLUSION: The yield of prospectively detected false negative diagnoses was significantly increased by targeting high-risk accession groups. When cytology laboratories serve diverse populations, stratifying accessions by risk to permit increased sampling from the proportionately higher risk categories is a simple and effective device to maximize the yield and benefit from rescreening.     

Staphylococcal enterotoxin B primes cytokine secretion and lytic activity in response to native bacterial antigens

Superantigens stimulate T-lymphocyte proliferation and cytokine production, but the effects of superantigen exposure on cell function within a complex, highly regulated immune response remain to be determined. In this study, we demonstrate that superantigen exposure significantly alters the murine host response to bacterial antigens in an in vitro coculture system. Two days after exposure to the superantigen staphylococcal enterotoxin B, splenocytes cultured with Streptococcus mutans produced significantly greater amounts of gamma interferon (IFN-gamma) and interleukin-12 than did sham-injected controls. The majority of IFN-gamma production appeared to be CD8(+) T-cell derived since depletion of this cell type dramatically reduced the levels of IFN-gamma. To study host cell damage that may occur following superantigen exposure, we analyzed cytotoxicity to "bystander" fibroblast cells cultured with splenocytes in the presence of bacterial antigens. Prior host exposure to staphylococcal enterotoxin B significantly enhanced fibroblast cytotoxicity in the presence of bacteria. Neutralization of IFN-gamma decreased the amount of cytotoxicity observed. However, a greater reduction was evident when splenocyte-bacterium cocultures were separated from the bystander cell monolayer via a permeable membrane support. Increased cytotoxicity appears to be primarily dependent upon cell-cell contact. Collectively, these data indicate that overproduction of inflammatory cytokines may alter the activity of cytotoxic immune cells. Superantigen exposure exacerbates cytokine production and lytic cell activity when immune cells encounter bacteria in vitro and comparable activities could possibly occur in vivo.     

Apolipoprotein E*3-Leiden transgenic mice as a test model for hypolipidaemic drugs

PURPOSE: We report an investigation into the distribution of proteoglycans (PGs) in normal, organ-cultured and dextran-treated human corneas. METHODS: Immunogold labeling was carried out at the electron microscope level to localize keratan sulphate (KS), chondroitin sulphate (CS), and heparan sulphate (HS) PGs. RESULTS: High levels of labeling for CS was found in the epithelium, endothelium, and keratocytes, with light labelling present in the basement membranes and the corneal stroma. Labeling for HS was present in the epithelium, endothelium, and keratocytes, with intense labeling present at the endothelium/Descemet's membrane interface and the epithelium/Bowman's layer interface. Large filaments were also observed in these regions in cuprolinic blue-stained specimens. Keratan sulphate was present at high levels in the stroma and the basement membranes with low levels present within the keratocytes, epithelium, and endothelium. The pattern of KS labeling along the collagen fibrils in the stroma sometimes showed evidence of periodicity. Organ-cultured corneas had extensive collagen-free "lakes," the interior of which immunolabeled positively for KS and showed staining with cuprolinic blue. The lakes were greatly reduced in the dextran-treated samples. CONCLUSION: This investigation determined the ultrastructural distribution of KS, CS, and HS PGs in human cornea and showed that organ culture is associated with a change in distribution of stromal PGs.     

Sputtered lead scandium tantalate thin films: a microstructural study

Lead scandium tantalate (PST) thin films have been deposited on a platinized silicon substrate with and without a buffer layer of MgO at the temperature of 525°C. It was found that PST films on the substrate without a buffer layer were strongly (1 1 1) oriented perovskite, whilst films on the substrate with a buffer layer showed the presence of second-phase pyrochlore, and the films were (1 1 1) and (1 1 0) oriented. These structural differences were believed to result from the structural differences between the platinum layers immediately below the respective PST layers. The lines which divide PST into network of islands were found to be no more than wider grain boundaries, rather than cracks as believed previously. Micro-beam diffraction and energy dispersive X-ray analysis showed that grain boundaries were tantalum-rich and lead-deficient compared to perovskite grain centres. Electrical properties, such as relative permittivity and dielectric loss, for the films were also measured.     

Induced candidosis in mice with artificially established oral flora

The aim of this study was to gauge the effect of an artificially established flora, unnatural for mice, on the induction of oral candidosis in mice. Four groups of BALB/c mice were compared; conventional Candida albicans-free mice, "germ-free" mice which had been inoculated with Candida-free human saliva, germ-free mice which had been exposed to a cocktail of Streptococcus mitis, S. sobrinus and S. sanguis, and uncontaminated germ-free mice. After exposure to C. albicans via drinking water, the four groups of mice were killed and their oral cavities examined for candidal growth and oral lesions. Conventional mice yielded significantly less candidal growth and exhibited significantly fewer oral lesions than the other three groups. Candidal lesions in the two groups of contaminated germ-free mice were significantly fewer than in the uncontaminated germ-free mice. The latter exhibited extensive candidal lesions with little inflammatory infiltrate. It is concluded that mice with human oral micro-organisms have some resistance against candidal infection albeit at a reduced level, that mice with natural oral flora are highly resistant, and that germ-free mice are extremely susceptible to C. albicans infection.