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41.
Glenwick David S.; Brodsky Stanley L.; Franks Cyril M.; Hess Allen K.; Balch Katherine; Frank Jerome B.; Garfield Sol L.; Jason Leonard A. 《Canadian Metallurgical Quarterly》1987,42(4):405
Discusses the factors that should be considered when preparing to edit a high-quality, scholarly psychology book. The issues discussed include the book editor–publisher relationship, the book editor–chapter contributor relationship, and what makes a good final product. Three laws of editing are offered: (1) conceptualize clearly; (2) edit fiercely; and (3) edit for the reader, not the writer. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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1. The effects of the volatile anesthetics enflurane, halothane, and isoflurane on gamma-aminobutyric acid (GABA) receptor-mediated inhibitory postsynaptic currents (IPSCs) were studied in cultured rat hippocampal neurons. The experimental concentrations of anesthetics were measured directly using gas chromatography. All three anesthetics increased the overall duration of IPSCs, measured as the time to half-decay (T1/2). Clinically effective concentrations of anesthetics [between 0.5 and 1.5 times MAC (minimum alveolar concentration)] produced between 100 and 400% increases in T1/2. These effects were fully reversible, and did not involve alterations in the reversal potential for the IPSC (EIPSC). 2. The decay of the IPSC was fitted as a sum of two exponential functions, yielding a fast component (tau fast = 20 ms), and a slow component (tau slow = 77 ms), such that the fast component accounted for 79% of the IPSC amplitude and 52% of the total charge transfer. All three anesthetics produced concentration-related increases in the amplitude and charge transfer of the slow component, while simultaneously decreasing the amplitude and charge transfer of the fast component. Thus T1/2 approximated tau fast under control conditions, but approximated tau slow in the presence of the anesthetics. 3. Varying the calcium chelating agents in the recording pipettes had no effect on the quality or magnitude of alterations in IPSC kinetics produced by halothane, suggesting that variations in intracellular calcium levels are not required for the effect of halothane on the time course of the IPSC. 4. The (+)-stereoisomer of isoflurane produced greater increases in the duration of the IPSC than the (-)-isomer when applied at approximately equal concentrations, suggesting that there is a structurally selective site of interaction for isoflurane that modulates the GABAA receptor. 5. These results suggest that the previously shown abilities of volatile anesthetics to potentiate responses to exogenously applied GABA and to prolong the duration of GABA-mediated synaptic inhibition may be due to an alteration in the gating kinetics of the GABAA receptor/channel complex. Prolongation of synaptic inhibition in the CNS is consistent with the physiological effects that accompany anesthesia and may contribute to the mechanism of anesthetic action. 相似文献
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Alexander Brodsky Yehoshua Sagiv 《Annals of Mathematics and Artificial Intelligence》1999,26(1-4):29-57
Datalog (i.e., function-free logic) programs with monotonicity constraints on extensional predicates are considered. A monotonicity
constraint states that one argument of a predicate or a constant is always less than another argument or a constant, according
to some strict partial order. Relations of an extensional database are required to satisfy the monotonicity constraints imposed
on their predicates. More specifically, a strict partial order is defined on the domain (i.e., set of constants) of the database,
and every tuple of each relation satisfies the monotonicity constraints imposed on its predicate. This paper focuses on the
problem of entailment of monotonicity constraints in the intensional database from monotonicity constraints in the extensional
database. The entailment problem is proven to be decidable, based on a suggested algorithm for computing sound and complete
disjunctions of monotonicity and equality constraints that hold in the intentional database. It is also shown that the entailment
of monotonicity constraints in programs is a complete problem for exponential time. For linear programs, this problem is complete
for polynomial space.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献
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Behavioral geneticists and evolutionary psychologists have generally pursued human behavioral analyses with little theoretical or methodological exchange. However, significant benefits might accrue from increased communication between these disciplines. The primary goals of this article are (1) to identify meaningful junctures between behavioral genetics and evolutionary psychology, (2) to describe behavioral genetic research designs and their applications to evolutionary analyses, and (3) to reassess current personality research in light of behavioral genetic and evolutionary concepts and techniques. The five-factor model of personality is conceptualized as subsuming variation in normative species-typical systems with adaptive functions in the human environment of evolutionary adaptation. Considered as universal evolved mechanisms, personality systems are often seen in dynamic conflict within individuals and as highly compartmentalized in their functioning between settings. However, genetically influenced individual differences in personality may also be understood within an evolutionary framework. Studies of the heritability of personality traits indicate broad-sense heritabilities in the 0.40-0.50 range with evidence of substantial nonadditive genetic variation and nonshared environmental influences. Evidence indicates that evolutionary theory (e.g., inclusive fitness theory) predicts patterns of social interaction (e.g., cooperation and bereavement) in relatives. Furthermore, variation in personality may constitute a range of viable strategies matching the opportunities available in the complex niche environment of human societies. Within this wide range of viable strategies, personality variation functions as a resource environment for individuals in the sense that personality variation is evaluated according to the interests of the evaluator (e.g., friendships, coalitions, or mate choice). 相似文献
49.
The explosion of new knowledge about the complex mechanisms mediating high blood pressure is providing new targets for drug therapy of hypertension and other cardiovascular disorders. This article reviews the current status of several new approaches in the management of hypertension, including vasopressin antagonists, natriuretic peptide clearance inhibitors, endothelin antagonists, renin inhibitors, angiotensin receptor antagonists, and selective T-type calcium ion channel antagonists. 相似文献
50.
NN Pribylova AI Tret''iakov AF Neronov MN Moskalev AI Kaminin NL Katyshev SI Portniagina 《Canadian Metallurgical Quarterly》1997,75(1):38-40
A correct access opening is the key to endodontics. An adequate anatomical access preparation maximizes cleaning, shaping, and obturation. The major objectives of access preparation are straight line access to the apical area, conservation of tooth structure, and unroofing of the pulp chamber. The safe-ended diamond bur technique provides an efficient and rapid means to obtain the objective of access preparation in posterior teeth. 相似文献