全文获取类型
收费全文 | 677篇 |
免费 | 1篇 |
专业分类
化学工业 | 4篇 |
机械仪表 | 1篇 |
建筑科学 | 1篇 |
矿业工程 | 1篇 |
轻工业 | 6篇 |
一般工业技术 | 1篇 |
冶金工业 | 661篇 |
自动化技术 | 3篇 |
出版年
2015年 | 1篇 |
2013年 | 2篇 |
2005年 | 1篇 |
2004年 | 2篇 |
2003年 | 1篇 |
2001年 | 1篇 |
1999年 | 22篇 |
1998年 | 190篇 |
1997年 | 107篇 |
1996年 | 77篇 |
1995年 | 47篇 |
1994年 | 26篇 |
1993年 | 51篇 |
1992年 | 17篇 |
1991年 | 11篇 |
1990年 | 8篇 |
1989年 | 12篇 |
1988年 | 7篇 |
1987年 | 6篇 |
1986年 | 5篇 |
1985年 | 9篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 4篇 |
1980年 | 4篇 |
1979年 | 1篇 |
1978年 | 2篇 |
1977年 | 20篇 |
1976年 | 38篇 |
1975年 | 2篇 |
1955年 | 1篇 |
排序方式: 共有678条查询结果,搜索用时 8 毫秒
101.
NR Walet 《Canadian Metallurgical Quarterly》1993,48(5):2222-2229
102.
HJ Super NR McCabe MJ Thirman RA Larson MM Le Beau J Pedersen-Bjergaard P Philip MO Diaz JD Rowley 《Canadian Metallurgical Quarterly》1993,82(12):3705-3711
Chromosome band 11q23 is frequently involved in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) de novo, as well as in myelodysplastic syndromes (MDS) and lymphoma. Five percent to 15% of patients treated with chemotherapy for a primary neoplasm develop therapy-related AML (t-AML) that may show rearrangements, usually translocations involving band 11q23 or, less often, 21q22. These leukemias develop after a relatively short latent period and often follow the use of drugs that inhibit the activity of DNA-topoisomerase II (topo II). We previously identified a gene, MLL (myeloid-lymphoid leukemia or mixed-lineage leukemia), at 11q23 that is involved in the de novo leukemias. We have studied 17 patients with t-MDS/t-AML, 12 of whom had cytogenetically detectable 11q23 rearrangements. Ten of the 12 t-AML patients had received topo II inhibitors and 9 of these, all with balanced translocations of 11q23, had MLL rearrangements on Southern blot analysis. None of the patients who had not received topo II inhibitors showed an MLL rearrangement. Of the 5 patients lacking 11q23 rearrangements, some of whom had monoblastic features, none had an MLL rearrangement, although 4 had received topo II inhibitors. Our study indicates that the MLL gene rearrangements are similar both in AML that develops de novo and in t-AML. The association of exposure to topo II-reactive chemotherapy with 11q23 rearrangements involving the MLL gene in t-AML suggests that topo II may play a role in the aberrant recombination events that occur in this region both in AML de novo and in t-AML. 相似文献
103.
EE Sanidas MI Filipe J Linehan NR Lemoine WJ Gullick T Rajkumar DA Levison 《Canadian Metallurgical Quarterly》1993,54(6):935-940
The pattern of c-erbB-3 gene product was studied in 91 advanced gastric carcinomas, adjacent hyperplastic mucosa, intestinal metaplasia and dysplasia and in normal controls, using immunohistochemistry in archival material. All tumours showed positive c-erbB-3 staining in both cytoplasm and membrane. No significant differences of expression were observed between intestinal and diffuse-type carcinomas or any other clinical parameters. Of interest is the expression in the adjacent mucosa, which is extensive, cytoplasmic, and of lower intensity than in the tumours. Further studies are currently being carried out to clarify the role of this protein in tumour behaviour and gastric carcinogenesis. 相似文献
104.
Forty-four patients underwent bipedal lymphography for evaluation of fever of unexplained origin, or because a malignant tumor (usually lymphoma) was suspected clinically. Extensive prior medical evaluation was inconclusive. The lymphograms were of no apparent value in detecting the etiology of the illness. Reactive follicular hyperplasia was frequently seen and sometimes simulated lymphoma on the lymphogram. The primary value of lymphography in such cases is as an aid in planning biopsy and surgery. 相似文献
105.
NR McCleave 《Canadian Metallurgical Quarterly》1998,111(1073):349-350
106.
107.
RD Zafonte NR Mann SR Millis KL Black DL Wood F Hammond 《Canadian Metallurgical Quarterly》1997,78(10):1103-1106
OBJECTIVE: To investigate the relation between duration of posttraumatic amnesia (PTA) and functional outcome in a traumatically brain injured population. PATIENTS: Two hundred seventy-six patients with traumatic brain injury (TBI) who were admitted to a Level I university trauma center and required inpatient rehabilitation. MEASURES: Duration of PTA was assessed by serial administrations of the Galveston Orientation Amnesia Test (GOAT). Functional Independence Measure (FIM) total scores, FIM cognitive and motor subscores, and Disability Rating Scale (DRS) scores were obtained at admission and discharge from inpatient rehabilitation. RESULTS: Duration of PTA was a significant predictor of all admission and discharge DRS and FIM scores. Duration of PTA and age at the time of injury, in combination, contributed significantly to the prediction of the DRS score and FIM total, cognitive, and motor scores at discharge. CONCLUSION: Duration of PTA appears to be a useful variable in predicting specific functional outcome in the TBI population receiving inpatient rehabilitation services. The use of age as a factor in addition to duration of PTA enhances the prediction of functional outcome. 相似文献
108.
Activity-dependent competition between afferents in the primary visual cortex of many mammals is a quintessential feature of neuronal development. From both experimental and theoretical perspectives, understanding the mechanisms underlying competition is a significant challenge. Recent experimental work suggests that geniculocortical afferents might compete for retrograde neurotrophic factors. We show that a mathematically well-characterized model of retrograde neurotrophic interactions, in which the afferent uptake of neurotrophic factors is activity-dependent and in which the average level of uptake determines the complexity of the axonal arbors of afferents, permits the anatomical segregation of geniculocortical afferents into ocular dominance columns. The model induces segregation provided that the levels of neurotrophic factors available either by activity-independent release from cortical cells or by exogenous cortical infusion are not too high; otherwise segregation breaks down. We show that the model exhibits changes in ocular dominance column periodicity in response to changes in interocular image correlations and that the model predicts that changes in intraocular image correlations should also affect columnar periodicity. 相似文献
109.
110.
NR Kamani 《Canadian Metallurgical Quarterly》1996,17(3):301-304