Orthogonalization of circular stationary vector sequences and itsapplication to the Gabor decomposition

Certain vector sequences in Hermitian or in Hilbert spaces, can be orthogonalized by a Fourier transform. In the finite-dimensional case, the discrete Fourier transform (DFT) accomplishes the orthogonalization. The property of a vector sequence which allows the orthogonalization of the sequence by the DFT, called circular stationarity (CS), is discussed in this paper. Applying the DFT to a given CS vector sequence results in an orthogonal vector sequence, which has the same span as the original one. In order to obtain coefficients of the decomposition of a vector upon a particular nonorthogonal CS vector sequence, the decomposition is first found upon the equivalent DFT-orthogonalized one and then the required coefficients are found through the DFT. It is shown that the sequence of discrete Gabor (1946) basis functions with periodic kernel and with a certain inner product on the space of N-periodic discrete functions, satisfies the CS condition. The theory of decomposition upon CS vector sequences is then applied to the Gabor basis functions to produce a fast algorithm for calculation of the Gabor coefficients     

Protein solution structure calculations in solution: solvated molecular dynamics refinement of calbindin D9k

Data were collected on the drinking behavior of 415 pregnant adolescents from 1990 to 1994. The relationships between knowledge and attitudes about drinking and drinking behavior were examined. Knowledge about drinking was not related to average daily volume of alcohol before or during pregnancy. Those with specific knowledge about fetal alcohol effects drank less before pregnancy, and in the first trimester, and were also less likely to drink to intoxication. Among drinkers, general knowledge about drinking was significantly related to a decrease in drinking between pre-pregnancy and first trimester, as well as between first and third trimesters. Those with more intolerant attitudes about drinking drank less before and during pregnancy. They had fewer episodes of binge drinking, intoxication, negative consequences, and problem drinking during pregnancy. They were more likely to decrease drinking from the first to third trimesters. These relationships are relevant to developing effective education programs for the high-risk group of pregnant teenagers who drink.     

Institutional arrangements for flood hazard management in Malaysia: an evaluation using the criteria approach

Institutional aspects of flood hazards significantly affect their outcomes in Malaysia. Institutional arrangements to deal with floods include: legislative activity, organisational structures, attitudes and sub-culture, and policies and instruments. When assessed in terms of four specific criteria, institutional aspects of flood hazards are found to be largely inadequate. Disaster reduction programmes are over-dependent on a reactive approach based largely on technology and not even aimed at floods specifically. Structural flood reduction measures are the predominant management tool and, although the importance of non-structural measures is recognised, thus far they have been under-employed. Current laws and regulations with regard to flood management are also insufficient and both the financial and human resources of flood hazard organisations are generally found to be wanting. Finally, economic efficiency, equity and public accountability issues are not adequately addressed by institutional arrangements for flood hazards.     

IL-12 gene therapy protects mice in lethal Klebsiella pneumonia

IL-12 is a proinflammatory cytokine that has recently been shown to have beneficial effects in the setting of acquired host immunity. To determine the role of IL-12 in innate immunity against Gram-negative bacterial organisms, CBA/J mice were challenged with 10(2) CFU of Klebsiella pneumoniae intratracheally (i.t.), resulting in the time-dependent expression of IL-12 mRNA (p35 and p40) and protein within the lung. Passive immunization of animals with anti-IL-12 serum i.p. at the time of K. pneumoniae inoculation resulted in a 12-fold increase in K. pneumoniae CFU in lung homogenates at 48 h, as compared with animals receiving control serum. In addition, treatment of Klebsiella-infected mice with anti-IL-12 Abs significantly decreased both short and long term survival. To assess the effect of compartmentalized IL-12 overexpression on outcome in Klebsiella pneumonia, animals were treated i.t. with 5 x 10(8) PFU of a nonreplicating adenoviral vector containing a human cytomegalovirus promoter and cDNAs coding for the p35 and p40 subunits of IL-12 inserted into the E1 and E3 domains (Ad5mIL-12), respectively. In vivo transfection with Ad5mIL-12 resulted in 45% long term survival in Klebsiella pneumonia, whereas no animals with Klebsiella pneumonia receiving control adenovirus survived. Moreover, treatment with anti-IFN-gamma Abs or soluble TNF receptor:Ig construct partially and completely attenuated survival benefits observed in animals receiving Ad5mIL-12, respectively. In conclusion, endogenous IL-12 is a critical component of antibacterial host defense, and the compartmentalized overexpression of IL-12 using recombinant adenoviral gene therapy represents a safe and effective approach to deliver IL-12 to the lung in the setting of murine Klebsiella pneumonia.     

Variable-rate tree-structured vector quantizers

In general, growth algorithms for optimal tree-structured vector quantizers do not exist. In this paper we show that if the source satisfies certain conditions; namely, that of diminishing marginal returns; optimal growth algorithms do exist. We present such an algorithm and compare its performance with that of other tree growth algorithms. Even for sources that do not meet the necessary conditions for the growth algorithm to be optimal, such as for speech with unknown statistics, it is seen by simulation that the algorithm outperforms other known growth algorithms, For sources that do not satisfy the required conditions, the algorithm presented here can also be used to grow the initial tree for the pruning process. The performance of such pruned trees is superior to that of trees pruned from full trees of the same rate     

Transfectable and transplantable postmitotic human neurons: a potential "platform" for gene therapy of nervous system diseases

OBJECTIVE: To evaluate F-18 fluorodeoxyglucose positron emission tomography (PET) in terms of its sensitivity and specificity in diagnosing malignant pulmonary nodules and staging bronchogenic carcinoma. METHODS: A retrospective review of any patient that presented to the VA Palo Alto Health Care System with a pulmonary nodule between 9/94 and 3/96 revealed 49 patients (four female, 45 male) age 37-85 (mean 63) with 54 pulmonary nodules who had: chest CT scan, PET scan; and tissue characterization of the nodule. Characterization of each nodule was achieved by histopathologic (N = 44) or cytopathologic (N = 10) analysis. Of the 49 patients, 18 had bronchogenic carcinoma which was adequately staged. Mediastinal PET and CT findings in these 18 patients were compared with the surgical pathology results. N2 disease was defined as mediastinal lymph node involvement by the American Thoracic Society's classification system. Mediastinal lymph nodes were interpreted as positive by CT if they were larger that 1.0 cm in the short-axis diameter. RESULTS: Sensitivity and specificity for the diagnosis of malignant pulmonary nodules using PET was 93 and 70%, respectively. All nodules (N = 3) that were falsely positive by PET scan were infectious in origin. All nodules (N = 4) that were falsely negative by PET were technically limited studies (outdated scanner, no attenuation correction, hyperglycemia) except for one case of metastatic adenocarcinoma. The sensitivity and specificity of PET in diagnosing N2 disease was 67 and 100%, compared with 56% and 100% for CT scan (not statistically significant). However, one more patient with N2 disease was correctly diagnosed by PET than by CT scan. CONCLUSION: PET is a valuable tool in the diagnosis and management of pulmonary nodules and may more accurately stage patients with bronchogenic carcinoma than CT scanning alone.     

A priori information in image analysis: assessment of intensity distribution for definition of shape and size of small vessels

A method for incorporating prior information in computer-based image analysis is described and critically evaluated. The specific application improves pixel resolution (spot size) and shape estimation of small vessel cross sections in exchange for dynamic range information. The potential subpixel spot size sensitivity for a 16-bit gray scale is better than one part in 32000. The performance of shape recovery is assessed in relation to signal-to-noise ratio, acquired image resolution, vessel shape complexity and aspect ratio. The process is shown to be effective and stable when the signal-to-noise ratio exceeds 10, when the number of pixels across the vessel is two or more, when the vessel contour has as many as six lobes, and when the aspect ratio is in the range 0.2-5.0.