高压二氧化碳保鲜双孢蘑菇的工艺优化

为了优化高压二氧化碳(high pressure carbon dioxide,HPCD)保鲜双孢蘑菇的工艺,在单因素实验基础上,采用响应面法分析HPCD处理压力、处理时间和处理温度对双孢蘑菇硬度和颜色的影响并对其进行优化。结果表明,HPCD保鲜双孢蘑菇的最佳工艺条件为:处理压力0.3 MPa,处理时间3 min,处理温度17℃;与对照相比,该条件HPCD处理后的双孢蘑菇可以更好的保持其硬度和颜色,低温贮藏8 d后的硬度为191.7 N(提高了18.85%),褐变指数(BI)为33.13(降低了16.80%)。因此,HPCD技术可以应用于双孢蘑菇的贮藏保鲜,具有良好的前景。      

基于改进BiSeNet的室内场景语义分割方法

室内场景的语义分割一直是深度学习语义分割领域的一个重要方向.室内语义分割主要存在的问题有语义类别多、很多物体类会有相互遮挡、某些类之间相似性较高等.针对这些问题,提出了一种用于室内场景语义分割的方法.该方法在BiSeNet(bilateral segmentation network)的网络结构基础上,引入了一个空洞金...     

Compound C Inhibits Renca Renal Epithelial Carcinoma Growth in Syngeneic Mouse Models by Blocking Cell Cycle Progression,Adhesion and Invasion

Compound C (CompC), an inhibitor of AMP-activated protein kinase, reduces the viability of various renal carcinoma cells. The molecular mechanism underlying anti-proliferative effect was investigated by flow cytometry and western blot analysis in Renca cells. Its effect on the growth of Renca xenografts was also examined in a syngeneic BALB/c mouse model. Subsequent results demonstrated that CompC reduced platelet-derived growth factor receptor signaling pathways and increased ERK1/2 activation as well as reactive oxygen species (ROS) production. CompC also increased the level of active Wee1 tyrosine kinase (P-Ser⁶⁴²-Wee1) and the inactive form of Cdk1 (P-Tyr¹⁵-Cdk1) while reducing the level of active histone H3 (P-Ser¹⁰-H3). ROS-dependent ERK1/2 activation and sequential alterations in Wee1, Cdk1, and histone H3 might be responsible for the CompC-induced G2/M cell cycle arrest and cell viability reduction. In addition, CompC reduced the adhesion, migration, and invasion of Renca cells in the in vitro cell systems, and growth of Renca xenografts in the BALB/c mouse model. Taken together, the inhibition of in vivo tumor growth by CompC may be attributed to the blockage of cell cycle progression, adhesion, migration, and invasion of tumor cells. These findings suggest the therapeutic potential of CompC against tumor development and progression.     

Rationale and Clinical Research Progress on PD-1/PD-L1-Based Immunotherapy for Metastatic Triple-Negative Breast Cancer

Metastatic triple-negative breast cancer (mTNBC), a highly aggressive and malignant tumor, currently lacks an effective treatment. There has been some progress in the treatment of mTNBC with programmed death receptor-1/programmed death ligand-1 (PD-1/PD-L1) immunotherapy in recent years. The combination of PD-1/PD-L1 inhibitors with other therapies is a noteworthy treatment strategy. Immunotherapy in combination with chemotherapy or small-molecule inhibitors still faces many challenges. Additionally, there are some new immunotherapy targets in development. We aimed to further evaluate the effectiveness and usefulness of immunotherapy for treating mTNBC and to propose new immunotherapy strategies. This review explains the rationale and results of existing clinical trials evaluating PD-1/PD-L1 inhibitors alone or in combination for the treatment of mTNBC. For patients with aggressive tumors and poor health, PD-1/PD-L1 inhibitors, either alone or in combination with other modalities, have proven to be effective. However, more research is needed to explore more effective immunotherapy regimens that will lead to new breakthroughs in the treatment of mTNBC.     

Ultra-small PbSe Quantum Dots Synthesis by Chemical Nucleation Controlling

Ultra-small PbSe quantum dots (QDs) were synthesized using conventional hot-injection method.A small amount of Sn was used as a nucleation promotion agent to control nucleation and growth during the QDs synthesis process.The average diameter of the QDs is about 1.6 nm,of which absorption peak centers at 550 nm and photoluminescence peak centers at 750 nm under 350 nm laser excitation with power as low as 500 μW.Transmission electron microscopy images confirm that the QDs size well matches with t...     

煤和瓦斯突出机理的流变假说

基于煤与瓦斯突出能量理论,建立了突出煤体三维结构应力模型,并利用弹塑性力学相关知识和数学求解方法推导了突出煤体的瓦斯弹性势能和瓦斯内能方程,为钻孔造穴诱突技术应用提供理论依据和实现路径。现场试验了钻孔水力造穴诱突、爆破诱突2种诱突技术措施,结果表明,钻孔造穴诱突过程的能量耗散机制符合推导的瓦斯能量方程和结构应力模型。针对试验矿井实际条件,2种诱突技术措施应用时存在一个阈值,当试验矿井煤层瓦斯含量大于9 m³/t时宜采用水力造穴诱突技术,反之宜采用爆破诱突技术。实践表明,2种诱突技术措施均能使试验矿井瓦斯治理效果显著提高。

     

基于BIM和移动定位的施工质量管理系统

本研究基于建筑信息模型(Building Information Modeling, BIM)技术和室内移动定位技术, 研制施工质量管理系统, 用于建筑工程施工质量验收, 以解决目前施工质量验收中规范实施过程中存在的漏检、数据二次转录等问题。本研究从施工质量验收相关规范出发, 分析了施工质量验收的标准化过程与要求, 并在此基础上设计了系统功能, 建立了系统架构。然后提出了基于BIM的验收任务生成算法、移动定位集成方法等关键技术与方法, 研制了施工质量管理的原型系统。最后, 该原型系统在实际工程施工中进行了试用, 验证了该系统的可行性。     

酶解制备玉米寡肽的研究

为了高效制备玉米寡肽,本实验对玉米蛋白粉进行超声预处理,以寡肽得率为评价指标,采用复合蛋白酶、碱性蛋白酶、风味蛋白酶、中性蛋白酶、胰蛋白酶、木瓜蛋白酶6种蛋白酶对其进行水解,筛选出碱性蛋白酶为制备玉米寡肽的最适水解用酶。通过单因素实验和响应面分析确定制备玉米寡肽的最适工艺条件为:加酶量2660U/g、底物浓度8.0g/100mL、反应温度57.0℃、反应pH为9.0、反应时间3h。在该条件下制备的玉米酶解产物的寡肽得率为34.34%±0.22%,与理论预测值的相对误差在±1%以内。      

苦杏仁脱苦方法研究进展

本文主要综述了杏仁、苦杏仁苷及苦杏仁脱苦的传统和现代方法,并对每种脱苦技术方法的优缺点进行了比较,同时也对极有可能用于产业化中的微波和超声波脱苦方法的发展趋势进行了展望。      

闪式提取法提取落叶松树皮中原花青素的研究

利用闪式提取法提取落叶松树皮中的原花青素。研究了乙醇体积分数、料液比、提取时间和提取温度对落叶松树皮中原花青素提取得率的影响。在单因素实验的基础上,运用正交实验对结果进行优化。结果表明,闪式提取法提取落叶松树皮中原花青素的优化条件为:乙醇体积分数为60%,料液比1∶25(g/mL),提取时间为4min,提取温度40℃。在此条件下进行验证实验,原花青素得率达11.42%。该方法操作简单、速度快、得率高,适用于落叶松树皮中原花青素的提取。