General topology optimization method with continuous and discrete orientation design using isoparametric projection

A general topology optimization method, which is capable of simultaneous design of density and orientation of anisotropic material, is proposed by introducing orientation design variables in addition to the density design variable. In this work, the Cartesian components of the orientation vector are utilized as the orientation design variables. The proposed method supports continuous orientation design, which is out of the scope of discrete material optimization approaches, as well as design using discrete angle sets. The advantage of this approach is that vector element representation is less likely to fail into local optima because it depends less on designs of former steps, especially compared with using the angle as a design variable (Continuous Fiber Angle Optimization) by providing a flexible path from one angle to another with relaxation of orientation design space. An additional advantage is that it is compatible with various projection or filtering methods such as sensitivity filters and density filters because it is free from unphysical bound or discontinuity such as the one at θ = 2π and θ = 0 seen with direct angle representation. One complication of Cartesian component representation is the point‐wise quadratic bound of the design variables; that is, each pair of element values has to reside in a given circular bound. To overcome this issue, we propose an isoparametric projection method, which transforms box bounds into circular bounds by a coordinate transformation with isoparametric shape functions without having the singular point that is seen at the origin with polar coordinate representation. A new topology optimization method is built by taking advantage of the aforementioned features and modern topology optimization techniques. Several numerical examples are provided to demonstrate its capability. Copyright © 2014 John Wiley & Sons, Ltd.     

Cerebral Hyperperfusion after Revascularization Inhibits Development of Cerebral Ischemic Lesions Due to Artery-to-Artery Emboli during Carotid Exposure in Endarterectomy for Patients with Preoperative Cerebral Hemodynamic Insufficiency: Revisiting the “Impaired Clearance of Emboli” Concept

The purpose of the present study was to determine whether cerebral hyperperfusion after revascularization inhibits development of cerebral ischemic lesions due to artery-to-artery emboli during exposure of the carotid arteries in carotid endarterectomy (CEA). In patients undergoing CEA for internal carotid artery stenosis (≥70%), cerebral blood flow (CBF) was measured using single-photon emission computed tomography (SPECT) before and immediately after CEA. Microembolic signals (MES) were identified using transcranial Doppler during carotid exposure. Diffusion-weighted magnetic resonance imaging (DWI) was performed within 24 h after surgery. Of 32 patients with a combination of reduced cerebrovascular reactivity to acetazolamide on preoperative brain perfusion SPECT and MES during carotid exposure, 14 (44%) showed cerebral hyperperfusion (defined as postoperative CBF increase ≥100% compared with preoperative values), and 16 (50%) developed DWI-characterized postoperative cerebral ischemic lesions. Postoperative cerebral hyperperfusion was significantly associated with the absence of DWI-characterized postoperative cerebral ischemic lesions (95% confidence interval, 0.001–0.179; p = 0.0009). These data suggest that cerebral hyperperfusion after revascularization inhibits development of cerebral ischemic lesions due to artery-to-artery emboli during carotid exposure in CEA, supporting the “impaired clearance of emboli” concept. Blood pressure elevation following carotid declamping would be effective when embolism not accompanied by cerebral hyperperfusion occurs during CEA.     

Mouse Gastric Epithelial Cells Resist CagA Delivery by the Helicobacter pylori Type IV Secretion System

The initial step in bacterial infection is adherence of the bacterium to the target cell surface. Helicobacter pylori exploits the interaction of bacterial adhesin protein HopQ with human epithelial CEACAMs (CEACAM1, 5, and 6) to stably adhere to gastric epithelial cells, which is necessary for delivery of the H. pylori CagA oncoprotein into the epithelial cells via a type IV secretion system. In contrast to human CEACAMs, however, HopQ does not interact with Ceacam1 (mouse CEACAM1) in vitro or in CHO cells ectopically expressing Ceacam1. Since the mouse genome lacks Ceacam5 and Ceacam6, no significant HopQ–Ceacam interaction may occur in mouse gastric epithelial cells. Here, we found that the mouse stomach has a much lower expression level of Ceacam1 than the expression level of CEACAM1 in the human stomach. Consistently, mouse gastric epithelial cells resist CagA delivery by cagA-positive H. pylori, and the delivery is restored by ectopic expression of human CEACAM1 or CEACAM5 in mouse gastric epithelial cells. Thus, despite the fact that mice are routinely used for H. pylori infection studies, a low expression level of Ceacam1 in the mouse stomach together with the loss or greatly reduced interaction of HopQ with Ceacams make the mouse an inappropriate model for studying the role of H. pylori-delivered CagA in gastric pathogenesis, including the development of gastric cancer.     

Reliability of multilayer ceramic capacitors with nickel electrodes

The reliability of multilayer ceramic capacitors (MLCCs) with Ni internal electrodes has been studied trom the viewpoint of partial oxygen pressure (P_O2) during firing. It is shown that the load-life time of the insulation resistance (1R) was prolonged by firing under low Po₂ annealing after firing, and the addition of dopants. It is also shown that the generation of oxygen vacancies led to the degradation of IR. Annealing treatment for the oxidation of the dielectric body accelerates the dielectric aging of MLCCs. It is found that the appropriate control of the P_O2 during firing can improve the reliability of MLCCs with Ni electrodes to a level as high as that of MLCCs with precious metal electrodes. Thus, we have developed an MLCC with Ni electrodes that features high reliability and a large capacitance of 10 μF for the Y5V characteristic and 4.7 μF for the X7R characteristic, both in the case of the C3216 (3.2 mm × 1.6 mm × 1.4 mm) form.     

Transverse Acoustic Response Measured by AC-cut Quartz Transducer in Superfluid Helium-3

No Heading The transverse acoustic response in the B phase of superfluid ³He has been measured using an AC-cut quartz transducer at a pressure of 17.0 bar. The measurements were performed by a CW bridge method at a frequency of 9.3 MHz utilizing a quadrature hybrid and a high-frequency lock-in amplifier. By sweeping frequency around the resonance frequency of the transducer, in-phase and quadrature responses of the resonance were obtained from the output of the lock-in amplifier. We successfully separated the quality factor and the resonance frequency. Quality factor of the transducer had a small dip just below T_c and increased as _n by cooling, while its resonance frequency decreased sharply at T_c and gradually recovered to the normal state value in the low temperature limit.PACS numbers: 67.57.Jj, 43.58.+z.     

Design and control of a microrobotic system using magneticlevitation

Presents a prototype microrobot based on magnetic principles. Miniature items are to be transported and assembled in hazardous environments. A microrobot can be remotely operated with 3 DOF in an enclosed environment by transferring magnetic energy and optical signals from outside. The magnetic drive unit consists of 8 electromagnets (4 pairs), 2 permanent magnets, a return yoke and a pole piece. The microrobot is manipulated under the pole piece by regulating magnetic field. It consists of a magnetic head, a body (electronic circuit and batteries), and copper alloy ribbon ringers. A shape memory alloy actuator activates the fingers by illuminating/extinguishing several LED. PID controls were applied. To cope with uncertainties and variations in payload masses, an adaptive control law was also employed for positioning along the z axis to enable the controller parameters to be adjusted in real-time. Effectiveness of the control was verified by the results of several experiments. The microrobot has a net mass of 8.1 g and it can elevate and manipulate objects with masses up to 1.5 g within a volume of 29×29×26 mm³ with a precision of 0.05 mm     

Sinterability of various high-purity magnesium oxide powders

The sinterability of high-purity MgO powders with different production histories was investigated to make clear the relationship between the powder characterization, the densification processes, and the changes in microstructure both with increasing temperature at a rate of 10° C min^–1 and at a fixed temperature of 1450° C for 5 h. The densification behaviour and the changes in microstructure of these compressed bodies were affected chiefly by their original surface activity and degree of agglomeration, depending on the production histories: (i) the ultra-fine and well-dispersed powder prepared by the vapour-phase oxidation process showed that densification proceeded with an appreciable grain growth with few closed pores remaining; (ii) powder derived from the sea-water magnesia process showed that the densification behaviour was affected by the species of magnesium salt, i.e. basic magnesium carbonate or magnesium hydroxide, used as a precursor; however, whichever magnesium salt was used, its sintered compact showed similar closed porosities and grain-size distributions; (iii) powder derived from the spark-discharge process contained skeletons of the original Mg(OH)₂ particles; however, the densification proceeded gradually with slow grain growth, reflecting the fact that the powder has a moderate surface area (36 m² g^–1). The sintered compact from (iii) had a small closed porosity and the smallest grain-size distribution among the compacts used in this investigation.     

Calcium isotope separation by band chromatography using 18-crown-6-ether resin

To develop the ⁴⁸Ca enrichment process, a feasibility study on a band chromatography was made using 9 M HCl solution and crown ether resin synthesized in porous silica beads. Prior to the chromatographic experiments, distribution coefficients, Kd, of Ca²⁺ and Sr²⁺ were measured at different concentrations of these ionic species. The frontal boundary of the chromatography was made by a usual manner of the breakthrough mode of calcium feeding, and the rear boundary was made by introducing strontium as a following ion on the basis of the observed Kd values. It was confirmed that the heavy isotope ⁴⁸Ca was depleted in the rear boundary region, while ⁴⁸Ca was enriched in the front boundary region. The values of separation coefficient ε (= α – 1) in three chromatographic operations at different temperatures were observed as 2 × 10^?3 ~ 3 × 10^?3. The separation coefficients observed in the front boundary regions, where ⁴⁸Ca was enriched, agreed with those observed in the rear boundary regions, where ⁴⁰Ca was enriched.     

Shear properties of metal-free wooden load-bearing walls using plywood jointed with a combination of adhesive tape and wood dowels

In this study, the potential of wood-only (metal-free) load-bearing walls was proposed and tested based on the idea of using the same type of material throughout wherever possible while improving basic properties such as strength, sound insulation, and heat insulation. Specifically, a technique was tested of combining pressure sensitive adhesive tape and wood dowels in place of nails for load-bearing structures with panel reinforcement represented by wood-frame construction. For this paper, its strength was evaluated by conducting in-plane shear tests, which revealed that the initial rigidity and maximum load of the proposed test specimens were greater than that of specimens using nails for jointing. However, the shear load factor, which is calculated based on some strength parameters and which forms the foundation of housing strength design, was slightly lower than that of the nail-jointed specimen. This was because there was a large decline in post-collapse resistance and a lower calculated absorbed energy caused by brittleness. The early detachment of panels was also revealed as a problem in the tests.