The potentials of indirect calorimetry in the differential assessment of the metabolic status of obese patients with insulin-independent diabetes mellitus

Twenty-one obese patients with non-insulin dependent diabetes mellitus, 16 female and 5 male ones, were fed similar isocaloric rations, differing only by the share of substitution of the traditional protein products (0%, 60%, 30%, 45%) in the Danpro-S, Danpro-Fibre soybean protein concentrate. The parameters tested were daily glycemia, C-peptides, blood hydrocortisone, and urinary excretion of nitrous metabolites. Indirect calorimetry was used to assess the protein, fat, and carbohydrate oxidation rates at rest. Addition of proteins of a plant origin to the diets of such patients was associated with significant changes of the energy metabolism at rest at the expense of increased oxidation of carbohydrates and reduced protein catabolism, that may be regarded as a favorable effect. In this patient population a 30% soybean diet brings about an almost maximal positive effect in patients with the first degree of obesity, whereas in those with the second degree of obesity such effect is attained by the 45% soybean diet.     

Surgical treatment of portal hypertension with ascites using ileovesicopexy under experimental conditions

Experiments conducted with albino rats have evidenced that under the effect of an atherogenic ration the level of lipids and cholesterol in the blood plasma and hepatic tissue and of sillac acids in the blood plasma increased. In the aortic intima the content of acid mucopolysaccharides was rising, this being attended by a concurrent swelling of the main interstitial substance and of the collagen fibers in the subendothelial layer. An addition of apple pectin or of cellulose to the atherogenic ration deferred the development of the mentioned changes.     

Insulin concentration in plasma from the femoral, hepatic and pancreatico-duodenal veins of dogs under standard conditions and in corisone glucose tolerance tests

In comparing the results of glucose tolerance tests conducted against the background of cortisone action and without it the former one proved to have advantages over the latter one in studying the incretory function of the pancreas. A biphasic character of insulin secretion in glucose loading was revealed with the aid of this test. Secretion of insulin by the pancreas was better reflected by the dynamics of insulin content in the blood of the pancreatic-duodenal vein that by the dynamics of its content in the blood of the peripheral veins.