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31.
OI Muraina R Tank C Dhingra JC Vuletin F Colella G Abdelsayed BR Pachter L Honikman 《Canadian Metallurgical Quarterly》1996,91(4):792-794
Extrapulmonary small cell carcinoma has been reported from multiple sites, including the gallbladder. Small cell carcinoma of the gallbladder is a very rare tumor, found usually in elderly women and associated with cholelithiasis. It carries a grave prognosis, metastasizing early and causing death shortly after diagnosis. Treatment of metastatic disease with two different chemotherapeutic regimens has been shown to improve survival. To the best of our knowledge, this tumor has not been previously reported in a black individual, or in any subject less than 49 yr or more than 79 yr old. We report two cases: one is the first black and youngest reported case. The second is the oldest person reported with this rare malignancy. Radiological studies such as ultrasound and CT scan were useful in evaluating tumor spread and follow-up. 相似文献
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NA Brazhenko ZI Kostina IuE Godes LL Krokhaleva ON Brazhenko OI Tsareva NM Balashova 《Canadian Metallurgical Quarterly》1998,114(5):48-51
AIM: The study of the detection rate and potential pathogenetic significance of antibodies to low density oxidated lipoprotein (LDOL) in patients who had ischemic cerebral circulation disorder (ICCD) at young age. MATERIALS AND METHODS: The examination (enzyme immunoassay, general and neurological investigations, laboratory and instrumental tests) covered 148 patients who survived ICCD at young age (mean age 37.2 years). RESULTS: 48 of 108 (44%) patients had LDOL antibodies. Antibodies to cardiolipin, lupus anticoagulant were recorded in 33 (31%) patients. LDOL antibodies were higher and occurred more frequently in patients with Sneddon's syndrome (35% of patients, mean LDOL antibodies-44 units) and primary antiphospholipid syndrome (17% of patients, 45 units) than in atherosclerotic affection of the major head arteries (4%, 29 units) or occlusion of cerebral arteries of unclear genesis (8% of patients, 29 units). CONCLUSION: ICCD were not related to fast development of cerebral atherosclerosis or periaortitis due to production of LDOL antibodies as no relationships were found between their rise and atherosclerotic lesions of cerebral major arteries or periaortitis as shown by ultrasonic dopplerography or cerebral angiography. Feasibility of LDOL antibodies participation in the coagulation cascade and induction of hypercoagulatory condition causing ICCD needs special investigation. 相似文献
34.
SS Marennikova PV Gashnikov OA Zhukova EI Riabchikova VV Strel''tsov OI Riazankina EV Chekunova NN Ianova SN Shchelkunov 《Canadian Metallurgical Quarterly》1996,(4):6-10
The study included 138 patients operated on for endo-extracellular pituitary adenomas which extend both intracranially and into the structures of the base of the skull. Operations via transcranial and transsphenoidal access to various tumor sites were performed in 38 patients (a main group), while 100 patients (a control group) underwent one of these operations. Two-stage operations, followed by removal of the suprasellar and basal regions of a tumor, are expedient for enhancing the efficiency of surgical treatment, reducing the incidence of complications associated with traumatic attempts at removing tumor parts hard-to-reach by transcranial or transsphenoidal approaches, as well as at reducing the number of relapses. At the first stage of surgical treatment it is advisable to make an intervention via transcranial access especially in cases of complex configuration of the suprasellar part of a tumor. The recommended interval between transcranial and transsphenoidal surgeries is 3-5 months. Two-stage surgical treatment does not lead to significant structural changes and to the increased number of complications, and to higher mortality rates as compared to one-stage surgery (transcranial or transsphenoidal surgeries alone). 相似文献
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Effect of the state of a melt on the glass-forming ability,structure, and properties of a melt-quenched bulk amorphous nickel-based alloy 总被引:1,自引:0,他引:1
N. V. Kurakova V. V. Molokanov I. V. Sterkhova P. P. Umnov V. I. Lad’yanov L. V. Kamaeva 《Russian Metallurgy (Metally)》2007,(6):519-523
The glass-forming ability, viscosity, phase composition, and microhardness of a melt-quenched Ni64.4Fe4Cr4.9Mn2B16.2C0.5Si8 bulk amorphous alloy quenched from various melt temperatures at near-critical rates are studied. The melt-quenching temperature ensuring the maximum glass-forming ability and microhardness (HV= 13 GPa) of the alloy is found to be 1200–1230°C. The melt viscosity is shown to behave anomalously near the solidification temperature, and the related factors favoring this anomalous behavior are detected. 相似文献
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Uvarov VYu YD Ivanov AN Romanov MO Gallyamov OI Kiselyova IV Yaminsky 《Canadian Metallurgical Quarterly》1996,78(8-9):780-784
In the present paper, the application of scanning tunneling microscopy in cytochrome P450s membrane topology is discussed. The method enables visualization of heme location in the lipid-bilayer-incorporated protein. It is supposed that the membrane-bound cytochrome P450 on the tunneling microscope substrate should behave as 'molecular diode'. A model explaining the liposome and the proteoliposome images observed is proposed. 相似文献
40.
M Carreau OI Gan L Liu M Doedens C McKerlie JE Dick M Buchwald 《Canadian Metallurgical Quarterly》1998,91(8):2737-2744
Fanconi anemia (FA) is a pleiotropic inherited disease that causes bone marrow failure in children. However, the specific involvement of FA genes in hematopoiesis and their relation to bone marrow (BM) failure is still unclear. The increased sensitivity of FA cells to DNA cross-linking agents such as mitomycin C (MMC) and diepoxybutane (DEB), including the induction of chromosomal aberrations and delay in the G2 phase of the cell cycle, have suggested a role for the FA genes in DNA repair, cell cycle regulation, and apoptosis. We previously reported the cloning of the FA group C gene (FAC) and the generation of a Fac mouse model. Surprisingly, the Fac -/- mice did not show any of the hematologic defects found in FA patients. To better understand the relationship of FA gene functions to BM failure, we have analyzed the in vivo effect of an FA-specific DNA damaging agent in Fac -/- mice. The mice were found to be highly sensitive to DNA cross-linking agents; acute exposure to MMC produced a marked BM hypoplasia and degeneration of proliferative tissues and caused death within a few days of treatment. However, sequential, nonlethal doses of MMC caused a progressive decrease in all peripheral blood parameters of Fac -/- mice. This treatment targeted specifically the BM compartment, with no effect on other proliferative tissues. The progressive pancytopenia resulted from a reduction in the number of early and committed hematopoietic progenitors. These results indicate that the FA genes are involved in the physiologic response of hematopoietic progenitor cells to DNA damage. 相似文献