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31.
OI Muraina R Tank C Dhingra JC Vuletin F Colella G Abdelsayed BR Pachter L Honikman 《Canadian Metallurgical Quarterly》1996,91(4):792-794
Extrapulmonary small cell carcinoma has been reported from multiple sites, including the gallbladder. Small cell carcinoma of the gallbladder is a very rare tumor, found usually in elderly women and associated with cholelithiasis. It carries a grave prognosis, metastasizing early and causing death shortly after diagnosis. Treatment of metastatic disease with two different chemotherapeutic regimens has been shown to improve survival. To the best of our knowledge, this tumor has not been previously reported in a black individual, or in any subject less than 49 yr or more than 79 yr old. We report two cases: one is the first black and youngest reported case. The second is the oldest person reported with this rare malignancy. Radiological studies such as ultrasound and CT scan were useful in evaluating tumor spread and follow-up. 相似文献
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NA Brazhenko ZI Kostina IuE Godes LL Krokhaleva ON Brazhenko OI Tsareva NM Balashova 《Canadian Metallurgical Quarterly》1998,114(5):48-51
AIM: The study of the detection rate and potential pathogenetic significance of antibodies to low density oxidated lipoprotein (LDOL) in patients who had ischemic cerebral circulation disorder (ICCD) at young age. MATERIALS AND METHODS: The examination (enzyme immunoassay, general and neurological investigations, laboratory and instrumental tests) covered 148 patients who survived ICCD at young age (mean age 37.2 years). RESULTS: 48 of 108 (44%) patients had LDOL antibodies. Antibodies to cardiolipin, lupus anticoagulant were recorded in 33 (31%) patients. LDOL antibodies were higher and occurred more frequently in patients with Sneddon's syndrome (35% of patients, mean LDOL antibodies-44 units) and primary antiphospholipid syndrome (17% of patients, 45 units) than in atherosclerotic affection of the major head arteries (4%, 29 units) or occlusion of cerebral arteries of unclear genesis (8% of patients, 29 units). CONCLUSION: ICCD were not related to fast development of cerebral atherosclerosis or periaortitis due to production of LDOL antibodies as no relationships were found between their rise and atherosclerotic lesions of cerebral major arteries or periaortitis as shown by ultrasonic dopplerography or cerebral angiography. Feasibility of LDOL antibodies participation in the coagulation cascade and induction of hypercoagulatory condition causing ICCD needs special investigation. 相似文献
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SS Marennikova PV Gashnikov OA Zhukova EI Riabchikova VV Strel''tsov OI Riazankina EV Chekunova NN Ianova SN Shchelkunov 《Canadian Metallurgical Quarterly》1996,(4):6-10
The study included 138 patients operated on for endo-extracellular pituitary adenomas which extend both intracranially and into the structures of the base of the skull. Operations via transcranial and transsphenoidal access to various tumor sites were performed in 38 patients (a main group), while 100 patients (a control group) underwent one of these operations. Two-stage operations, followed by removal of the suprasellar and basal regions of a tumor, are expedient for enhancing the efficiency of surgical treatment, reducing the incidence of complications associated with traumatic attempts at removing tumor parts hard-to-reach by transcranial or transsphenoidal approaches, as well as at reducing the number of relapses. At the first stage of surgical treatment it is advisable to make an intervention via transcranial access especially in cases of complex configuration of the suprasellar part of a tumor. The recommended interval between transcranial and transsphenoidal surgeries is 3-5 months. Two-stage surgical treatment does not lead to significant structural changes and to the increased number of complications, and to higher mortality rates as compared to one-stage surgery (transcranial or transsphenoidal surgeries alone). 相似文献
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AA Markin LB Stroganova LV Vostrikova OI Balashov IA Nichiporuk 《Canadian Metallurgical Quarterly》1997,31(4):64-70
Blood biochemical parameters of lipid, protein, carbohydrate and energy metabolism were measured in a 135-day chamber experiment. Also, dynamics of the intensity of lipid peroxidation and status of the antioxidant defence system were evaluated. Results of the investigation showed that extended chamber isolation led to modifications of several biochemical parameters including hemoglobin, bilirubin, cholesterol and its fractions, elevated transaminase activity which are typical for long-term space mission. However, these were not accompanied by substantive changes in protein, energy and carbohydrate metabolisms, or intensity of free radical processes. Effects of prolonged stay in chamber was successfully counterbalanced by organism. 相似文献
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For the selection of compounds affecting the hemorrheologic status a method for reproducing disorders of blood rheologic properties in vitro was developed. It consists in 60-min incubation of blood at 42 degrees C. The hemorrheologic effect of quercetin under such conditions was studied and a dependence of the effect of quercetin on blood viscosity and red cell aggregation on the drug concentration was revealed. 相似文献
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Uvarov VYu YD Ivanov AN Romanov MO Gallyamov OI Kiselyova IV Yaminsky 《Canadian Metallurgical Quarterly》1996,78(8-9):780-784
In the present paper, the application of scanning tunneling microscopy in cytochrome P450s membrane topology is discussed. The method enables visualization of heme location in the lipid-bilayer-incorporated protein. It is supposed that the membrane-bound cytochrome P450 on the tunneling microscope substrate should behave as 'molecular diode'. A model explaining the liposome and the proteoliposome images observed is proposed. 相似文献