Efficient itinerary recommendation via personalized POI selection and pruning

Knowledge and Information Systems - Personalized itinerary recommendation has garnered wide research interests for their ubiquitous applications. Recommending personalized itineraries is complex...     

Co-capping studies reveal CD8/TCR interactions after capping CD8 beta polypeptides and intracellular associations of CD8 with p56(lck)

A reaction-diffusion model was developed to predict the fate of nitric oxide (NO) released by cells of the immune system. The model was used to analyze data obtained previously using macrophages attached to microcarrier beads suspended in a stirred vessel. Activated macrophages synthesize NO, which is oxidized in the culture medium by molecular oxygen and superoxide (O2-, also released by the cells), yielding mainly nitrite (NO2-) and nitrate (NO3-) as the respective end products. In the analysis the reactor was divided into a "stagnant film" with position-dependent concentrations adjacent to a representative carrier bead and a well-mixed bulk solution. It was found that the concentration of NO was relatively uniform in the film. In contrast, essentially all of the O2- was calculated to be consumed within approximately 2 microm of the cell surfaces, due to its reaction with NO to yield peroxynitrite. The decomposition of peroxynitrite caused its concentration to fall to nearly zero over a distance of approximately 30 microm from the cells. Although the film regions (which had an effective thickness of 63 microm) comprised just 2% of the reactor volume and were predicted to account for only 6% of the NO2- formation under control conditions, they were calculated to be responsible for 99% of the NO3- formation. Superoxide dismutase in the medium (at 3.2 microM) was predicted to lower the ratio of NO3- to NO2- formation rates from near unity to <0.5, in reasonable agreement with the data. The NO3-/NO2- ratio was predicted to vary exponentially with the ratio of O2- to NO release rates from the cells. Recently reported reactions involving CO2 and bicarbonate were found to have important effects on the concentrations of peroxynitrite and nitrous anhydride, two of the compounds that have been implicated in NO cytotoxicity and mutagenesis.     

Tissue dynamics spectroscopy for three-dimensional tissue-based drug screening

Tissue dynamics spectroscopy combines dynamic light scattering with short-coherence digital holography to capture intracellular motion inside multicellular tumor spheroid tissue models. The cellular mechanical activity becomes an endogenous imaging contrast agent for motility contrast imaging. Fluctuation spectroscopy is performed on dynamic speckle from the proliferating shell and hypoxic core to generate drug-response spectrograms that are frequency versus time representations of the changes in spectral content induced by an applied compound or an environmental perturbation. A combination of 28 reference compounds and conditions applied to rat osteogenic UMR-106 spheroids generated spectrograms that were crosscorrelated in a similarity matrix used for unsupervised hierarchical clustering of similar compound responses. This work establishes the feasibility of tissue dynamics spectroscopy for three-dimensional tissue-based phenotypic profiling of drug response as a fully endogenous probe of the response of tissue to reference compounds.     

Will the experience of playing a violent role in a video game influence people’s judgments of violent crimes?

The present study investigates the impact of the experience of role playing a violent character in a video game on attitudes towards violent crimes and criminals. People who played the violent game were found to be more acceptable of crimes and criminals compared to people who did not play the violent game. More importantly, interaction effects were found such that people were more acceptable of crimes and criminals outside the game if the criminals were matched with the role they played in the game and the criminal actions were similar to the activities they perpetrated during the game. The results indicate that people’s virtual experience through role-playing games can influence their attitudes and judgments of similar real-life crimes, especially if the crimes are similar to what they conducted while playing games. Theoretical and practical implications are discussed.     

Industrial implementation of controller performance analysis technology

In this paper, a controller performance monitoring technology is introduced with a focus on its industrial implementation and applications. The technology to be introduced in this paper is known as Performance Analysis Toolbox and Solutions (PATS). The main components are discussed, which include data collection, closed-loop systems identification, control valve stiction monitoring, univariate control performance monitoring, multivariate control performance monitoring, model predictive control performance monitoring, etc. It is shown, through a thorough industry case study with various components of PATS, that the integration of the technology provides more convincing diagnosis results and facilitates identification of control improvement opportunities. Some components of the developed technology can be downloaded from the website http://www.ualberta.ca/～bhuang/research/research.htm.     

Filtering Data Streams for Entity-Based Continuous Queries

The idea of allowing query users to relax their correctness requirements in order to improve performance of a data stream management system (e.g., location-based services and sensor networks) has been recently studied. By exploiting the maximum error (or tolerance) allowed in query answers, algorithms for reducing the use of system resources have been developed. In most of these works, however, query tolerance is expressed as a numerical value, which may be difficult to specify. We observe that in many situations, users may not be concerned with the actual value of an answer, but rather which object satisfies a query (e.g., "who is my nearest neighbor?”). In particular, an entity-based query returns only the names of objects that satisfy the query. For these queries, it is possible to specify a tolerance that is "nonvalue-based.” In this paper, we study fraction-based tolerance, a type of nonvalue-based tolerance, where a user specifies the maximum fractions of a query answer that can be false positives and false negatives. We develop fraction-based tolerance for two major classes of entity-based queries: 1) nonrank-based query (e.g., range queries) and 2) rank-based query (e.g., k-nearest-neighbor queries). These definitions provide users with an alternative to specify the maximum tolerance allowed in their answers. We further investigate how these definitions can be exploited in a distributed stream environment. We design adaptive filter algorithms that allow updates be dropped conditionally at the data stream sources without affecting the overall query correctness. Extensive experimental results show that our protocols reduce the use of network and energy resources significantly.     

Regularizers for fault tolerant multilayer feedforward networks

Fault tolerance is an important issue for multilayer feedforward networks (MFNs). However, in the classical training approach for open node fault and open weight fault, we should consider many potential faulty networks. Clearly, if the number of faulty networks considered in the objective function is large, this training approach would be very time consuming. This paper derives two objective functions for attaining fault tolerant MFNs. One objective function is designed for handling open node fault while another one is designed for handling open weight fault. With the linearization technique, each of these two objective functions can be decomposed into two terms, the training error and a simple regularization term. In our approach, the objective functions are computationally simple. Hence the conventional backpropagation algorithm can be simply applied to handle these fault tolerant objective functions.     

Multiwalled carbon nanotubes grafted chitosan nanobiocomposite: A prosperous functional nanomaterials for glucose biosensor application

Multiwalled carbon nanotubes (MWNTs) grafted chitosan (CS) nanowire (NW) was prepared by phase separation method. Glucose oxidase (GOx) was sequentially immobilized into MWNT-CS-NW to obtain MWNT-CS-NW/GOx biosensor. Field emission scanning electron microscopy (FESEM) images of MWNT-CS-NW/GOx reveals the existence of MWNT and CS. Cyclic voltammetry and amperometry were used to evaluate the electrochemical determination of glucose. The MWNT-CS-NW/GOx biosensor shows an excellent performance for glucose at +0.34 V with a high sensitivity (5.03 μA/mM) and lower response time (3 s) in a wide concentration range of 1-10 mM (correlation coefficient of 0.9988). In addition, MWNT-CS-NW/GOx biosensor possesses better reproducibility, storage stability and there is negligible interference from other electroactive components.     

A small‐area and low‐power data driver IC using two‐stage DAC with a capacitor array for active matrix flat‐panel displays

A small‐area and low‐power data driver integrated circuit (IC) using a two‐stage digital‐to‐analog converter (DAC) with a capacitor array is proposed for active matrix flat‐panel displays. The proposed data driver IC employs a capacitor array in the two‐stage DAC so as to reduce the DAC area and eliminate the need for a resistor string, which has high‐power consumption. To verify the proposed two‐stage DAC, a 20‐channel data driver IC with the proposed 10‐bit two‐stage DAC was fabricated using a 0.18‐μm complementary metal–oxide–semiconductor process with 1.8 and 6 V complementary metal–oxide–semiconductor devices. The proposed 10‐bit two‐stage DAC occupies only 43.8% of the area of a conventional 10‐bit two‐stage DAC. The measurement results show that the differential nonlinearity and integral nonlinearity are +0.58/?0.52 least significant bit and +0.62/?0.59 least significant bit, respectively. The measured interchannel deviation of the voltage outputs is 8.8 mV, and the measured power consumption of the 20‐channel data driver IC is reduced to 7.1 mW, which is less than half of the power consumed by the conventional one.