Diagnostic utility of video EEG monitoring in paroxysmal events

A total of 89 suicide attempters were diagnosed according to the DSM-III-R, and categorized according to suicide method as 'violent' and 'non-violent' attempters, and also as those who had made previous suicide attempts ('repeaters') and those who had not ('non-repeaters'). All of the subjects completed the MNT questionnaire. Our hypothesis was that the temperament patterns would reflect specific clinical characteristics, such as psychiatric diagnoses and type of suicidal behaviour. The 'validity' (ranging from fatiguableness to a high level of psychic energy) showed a bimodal distribution, suggesting the existence of two subgroups. The subjects with adjustment disorders displayed a significantly higher mean validity than the other patients. The lowest validity scores were found in subjects with bipolar depression. Men showed significantly higher 'stability' (reflecting emotional distance from others) than women. Subjects with major depression and those who were 'violent' suicide attempters showed somewhat higher 'solidity' (unchangeability, non-impulsiveness) compared with the other groups. Female 'non-repeaters' displayed significantly lower solidity than males or other females. In general, no clear temperament patterns were detected in patients categorized according to type of suicidal behaviour. In contrast to the findings of studies of normal populations, the intercorrelations between the dimensions were considerable, especially among the men. This prompted us to perform a cluster analysis procedure in which the subjects were allocated to five clusters according to the MNT dimensions. No distinct clinical characteristics appeared in these clusters, except in the cluster with the highest validity and the lowest stability, as 54% (P = 0.014) of the patients in this cluster had an adjustment disorder diagnosis. These temperament results reflect the clinical heterogeneity of patients who attempt suicide.     

A geographic gradient in small rodent density fluctuations: a statistical modelling approach

The patterns of density dependence in Fennoscandian rodents are investigated statistically using a linear autoregressive scheme. Nineteen time series of microtine abundances along a latitudinal gradient in Fennoscandia from 60 degrees N to 69 degrees N are analysed. We provide statistical evidence that there exists a latitudinal gradient in density dependence in Fennoscandian microtines. Southern populations experience significantly stronger direct density dependence than northern populations. Delayed density dependence was significantly negative throughout the region and appeared constant across the latitudinal gradient. The populations consistently exhibit dynamics of second order throughout the region. Together, the clinal direct density dependence and constant delayed density dependence give rise to a cline in cycle period from 3 to 4.5 years. The statistical results are compared to assumptions and predictions made in previous studies on the geographic gradient in the population dynamics of these rodents. The results are in agreement with the predictions of the 'generalist predator hypothesis'.     

The diagnosis of chronic dust-induced bronchitis

In dust-induced bronchitis, alterations in the pulmonary parenchyma present themselves in the main cellular indices for bronchioalveolar lavage (BAL), thought to be of much importance to its diagnosis. A total of 53 patients with initial and manifest forms of dust bronchitis underwent BAL. There has been found the following: a decrease in the mononuclear phagocyte system cells (MPhS) reflecting the state of local cellular immunity; rise in the amounts of coniophages, suggesting phagocytic activity of alveolar macrophages (AM) and dust blockade of MPhS cells; emergence and augmentation of counts of gigantic Pirogov-Langhans' cells characteristic of tuberculous granulomas, and also decrease in the counts of lymphocytes. There is a striking decrement in the vitality of AM, with polycytosis being commonly seen. Detection of granular forms of Mycobacterium tuberculosis in BAL and Pirogov-Langhans' cells enables a major proportion of "dust-induced bronchitis" to be considered as belonging to the silicotuberculous process.     

高能效、高可靠性和高功率密度的同步降压稳压器的设计

同步降压稳压器是一种常用的电源,行业越来越趋向于追求高能效、高可靠性、高功率密度的设计方案.功率MOSFET广泛用于降压稳压器中,它们消耗大部分的损耗功率,通常决定了稳压器的整体能效.本文从动态性能、能效设计等角度出发,介绍了如何快速设计出高效可靠的同步降压稳压器, 详细介绍了电容、电感、控制FET及同步FET的参数选择方法,并给出了相应的计算公式及设计实例.最后介绍了在线设计工具Power Supply WebDesigner,避免了在处理和优化MOSFET功耗时较为繁琐的计算,简化了设计流程.     

安森美半导体绿色节能技术造就高能效液晶电视

阐述了绿色节能规范为液晶电视制造商带来的挑战,分析了安森美半导体液晶电视电源管理解决方案,给出了其架构组成及工作原理,并分析了其应用优势。     

氢化锆中氢的散射律和散射矩阵研究

从氢化锆晶体散射律的角度出发，研究了氢化锆晶体散射的特殊机理。根据氢化锆晶体散射的声学模型和光学模型给出的频谱分布，用国际通用程序ＧＡＳＫＥＴ计算了氢化锆中氢的散射律。     

On the Rotational Analysis of the Ground Vibrational State of CH3D Molecule

Three-dimensional quantitative structure-activity relationship (3D-QSAR) models have been developed using comparative molecular field analysis (CoMFA) on a large data set (118 compounds) of diverse cyclic urea derivatives as protease inhibitors against the human immunodeficiency virus type 1 (HIV-1). X-ray crystal structures of HIV-1 protease bound with this class of inhibitors were used to derive the most probable bioactive conformations of the inhibitors. The enzyme active site was used as a constraint to limit the number of possible conformations that are sterically accessible. The test sets have been created keeping in mind structural diversity as well as the uniform simple statistical criteria (mean, standard deviation, high and low values) of the protease inhibitory activities of the molecules compared to the training sets. Multiple predictive models have been developed with the training sets (93 compounds in each set) and validated with the corresponding test sets (25 compounds in each set). All the models yielded high predictive correlation coefficients (q2 from 0.699 to 0.727), substantially high fitted correlation coefficients (r2 from 0.965 to 0.973), and reasonably low standard errors of estimates (S from 0. 239 to 0.265). The steric and electrostatic effects have approximately equal contributions, 45% and 55% (approximately), respectively, toward explaining protease inhibitory activities. This analysis yielded models with significant information on steric and electrostatic interactions clearly discerned by the respective coefficient contour plots when overlapped on the X-ray structure of the HIV-1 protease. The HINT CoMFA study revealed significant contribution of hydrophobicity toward protease inhibitory activity. The 3D visualization technique utilizing these contour plots as well as the receptor site geometry may significantly improve our understanding of the inhibitor-protease (HIV-1) interactions and help in designing compounds with improved activity.     

复合钒钼酸干凝胶薄膜的制备及其湿敏特性研究

以V2O5 和Mo粉为起始物质,通过溶胶-凝胶法制备了复合钒钼酸(H2V9Mo3O32.3·nH2O)干凝胶薄膜,薄膜为层状结构,V和Mo分别以V5 和Mo6 存在;在11%～95%RH的范围内,复合钒钼酸干凝胶薄膜具有很好的湿敏特性,响应、恢复时间分别为6s和15s,感湿温度系数为0.5%RH/℃.