Immune response to Philadelphia chromosome-positive acute lymphoblastic leukemia induced by expression of CD80, interleukin 2, and granulocyte-macrophage colony-stimulating factor

We examined the potential of generating an immune response against Philadelphia chromosome-positive acute lymphoblastic leukemia. The immunostimulatory molecules chosen for this study were the cytokines IL-2 and GM-CSF and the costimulatory ligand CD80 (B7.1). We used a murine model based on a BALB/c pre-B cell line, BM185wt, in which leukemia is induced by the p185 BCR-ABL oncogenic product, which reproduces Philadelphia chromosome-positive ALL. BM185wt cells were transduced with retroviral vectors and the transduced clones expressing mIL-2, mGM-CSF, or mCD80 were used for challenge. Expression of the immunomodulators by BM185 cells was correlated with delay in leukemia development in immunocompetent mice, but not in immunodeficient mice, indicating an immune response against the modified leukemia cells. Expression of CD80 caused leukemia rejection in 50% of the cohort, which was associated with the CD4+ and CD8+ T cell-dependent development of anti-leukemia cytotoxic T lymphocytes. Furthermore, mice surviving the BM185/CD80 challenge or preimmunized with irradiated BM185/CD80 cells developed an immune response against subsequent challenge with the parental leukemia. These studies provide evidence that immunotherapeutic approaches can be developed for the treatment of ALL.     

Use of laser irradiation in the surgical treatment of pulmonary echinococcosis

Unilateral disturbance of nasal respiration was modeled in albino rats. All animals developed deformations of the skull in the sagittal and transversal planes. The pathogenesis of deformations is connected with neurotrophic disorders and injury to the nasal cartilaginous structures responsible for the skull growth.     

安森美半导体AC-DC非隔离高功率因数LED驱动方案

本文介绍了安森美半导体用于非隔离型AC-DC中低功率通用照明LED驱动器应用方案,给出试验样板的技术参数和测试结果。     

安森美半导体先进汽车照明解决方案点亮汽车内外

LED照明具有寿命长、响应时间快、节能环保等优点,使其在汽车照明中的应用不断扩大。本文详细介绍了安森美半导体在汽车照明应用中的各类LED单芯片驱动器解决方案。     

应对LED通用照明挑战的AC-DC LED驱动解决方案

系统介绍了安森美半导体为LED照明应用,特别是通用照明的驱动解决方案,主要介绍用于LED照明的AC-DC电源方案及相关电路。     

汽车信息娱乐系统电源方案

本文介绍了安森美半导体汽车信息娱乐系统多种电源设计方案及应用案例。     

316Ti不锈钢环境敏感断裂起裂时间研究

采用慢应变速率和恒载荷试验方法,研究在压水堆一次侧工况下氯离子浓度,氧浓度,加载应力和应速率对ＰＷＲ压力边界材料３１６Ｔｉ不锈钢环境促进起裂时间的影响。