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101.
Alexander V. Blagov Sergey Kozlov Tatiana Blokhina Vasily N. Sukhorukov Aleksander N. Orekhov 《International journal of molecular sciences》2022,23(23)
Cardiovascular diseases are one of the leading causes of death worldwide. The identification of new pathogenetic targets contributes to more efficient development of new types of drugs for the treatment of cardiovascular diseases. This review highlights the problem of mitochondrial dynamics disorders, in the context of cardiovascular diseases. A change in the normal function of mitochondrial dynamics proteins is one of the reasons for the development of the pathological state of cardiomyocytes. Based on this, therapeutic targeting of these proteins may be a promising strategy in the development of cardiac drugs. Here we will consider changes for each process of mitochondrial dynamics in cardiovascular diseases: fission and fusion of mitochondria, mitophagy, mitochondrial transport and biogenesis, and also analyze the prospects of the considered protein targets based on existing drug developments. 相似文献
102.
Anastasia V. Poznyak Larisa Litvinova Paolo Poggio Donato Moschetta Vasily Nikolaevich Sukhorukov Alexander N. Orekhov 《International journal of molecular sciences》2022,23(17)
Atherosclerosis is a common cause of cardiovascular disease, which, in turn, is often fatal. Today, we know a lot about the pathogenesis of atherosclerosis. However, the main knowledge is that the disease is extremely complicated. The development of atherosclerosis is associated with more than one molecular mechanism, each making a significant contribution. These mechanisms include endothelial dysfunction, inflammation, mitochondrial dysfunction, oxidative stress, and lipid metabolism disorders. This complexity inevitably leads to difficulties in treatment and prevention. One of the possible therapeutic options for atherosclerosis and its consequences may be metformin, which has already proven itself in the treatment of diabetes. Both diabetes and atherosclerosis are complex metabolic diseases, the pathogenesis of which involves many different mechanisms, including those common to both diseases. This makes metformin a suitable candidate for investigating its efficacy in cardiovascular disease. In this review, we highlight aspects such as the mechanisms of action and targets of metformin, in addition to summarizing the available data from clinical trials on the effective reduction of cardiovascular risks. 相似文献
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105.
Siarhei A. Dabravolski Nikolay K. Sadykhov Andrey G. Kartuesov Evgeny E. Borisov Vasily N. Sukhorukov Alexander N. Orekhov 《International journal of molecular sciences》2022,23(13)
Zinc plays an important role in cardiomyocytes, where it exists in bound and histochemically reactive labile Zn2+ forms. Although Zn2+ concentration is under tight control through several Zn2+-transporters, its concentration and intracellular distribution may vary during normal cardiac function and pathological conditions, when the protein levels and efficacy of Zn2+ transporters can lead to zinc re-distribution among organelles in cardiomyocytes. Such dysregulation of cellular Zn2+ homeostasis leads to mitochondrial and ER stresses, and interrupts normal ER/mitochondria cross-talk and mitophagy, which subsequently, result in increased ROS production and dysregulated metabolic function. Besides cardiac structural and functional defects, insufficient Zn2+ supply was associated with heart development abnormalities, induction and progression of cardiovascular diseases, resulting in accelerated cardiac ageing. In the present review, we summarize the recently identified connections between cellular and mitochondrial Zn2+ homeostasis, ER stress and mitophagy in heart development, excitation–contraction coupling, heart failure and ischemia/reperfusion injury. Additionally, we discuss the role of Zn2+ in accelerated heart ageing and ageing-associated rise of mitochondrial ROS and cardiomyocyte dysfunction. 相似文献
106.
Siarhei A. Dabravolski Nikita G. Nikiforov Alexander D. Zhuravlev Nikolay A. Orekhov Andrey V. Grechko Alexander N. Orekhov 《International journal of molecular sciences》2022,23(3)
Ageing is an unavoidable multi-factorial process, characterised by a gradual decrease in physiological functionality and increasing vulnerability of the organism to environmental factors and pathogens, ending, eventually, in death. One of the most elaborated ageing theories implies a direct connection between ROS-mediated mtDNA damage and mutations. In this review, we focus on the role of mitochondrial metabolism, mitochondria generated ROS, mitochondrial dynamics and mitophagy in normal ageing and pathological conditions, such as inflammation. Also, a chronic form of inflammation, which could change the long-term status of the immune system in an age-dependent way, is discussed. Finally, the role of inflammaging in the most common neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, is also discussed. 相似文献
107.
Questions on the behavior of the graphite melting curve have remained open during the last fifty years. The process of graphite melting in the pressure range of 2–14 GPa is investigated by the method of molecular dynamics using the model of reactive interatomic potential; the dynamics of melting-front propagation upon crystal superheating is considered, and the melting curve is plotted. The self-diffusion coefficient in the liquid phase is determined for the aforementioned pressure range, and the question of the existence of the liquid-liquid phase transition in carbon is considered. 相似文献
108.
109.
R. M. Khafizov’s paper was published in the No. 6 issue of the 2008 journal. In the present journal, we are publishing commentaries
submitted by Yu. K. Zaretskii and V. V. Orekhov within the framework of discussion.
Translated from Osnovaniya, Fundamenty i Mekhanika Gruntov, No. 1, p. 11, January-February, 2009. 相似文献
110.
V. A. Volodin M. D. Efremov A. I. Nikiforov D. A. Orekhov O. P. Pchelyakov V. V. Ul’yanov 《Semiconductors》2003,37(10):1190-1194
Germanium nanoislands formed on a Si (111) surface coated with an ultrathin oxide layer were investigated by Raman spectroscopy. For analysis of the experimental data, the spectra of real islands containing some hundreds of Ge atoms were calculated numerically. The effects of the resonance enhancement of the intensity of Raman scattering in the Ge-nanoisland-SiO2-Si system and the influence of the lateral sizes of nanoislands on the frequencies of phonons localized in them are discussed. 相似文献