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141.
L. A. Tseitlin A. K. Mendelenko P. D. Orekhov K. Ya. Neskoromnyi V. I. Zvyagin N. K. Shabal A. I. Grigor'ev 《Refractories and Industrial Ceramics》1973,14(7-8):395-396
Conclusions The mortar division of the Suvorov Mining Commission has organized the production of ramming chamotte bodies with an addition of orthophosphoric acid. The finished goods are delivered to the Novmoskov Firebrick Factory where a technology is being developed for making large shapes from these bodies of complex configuration fired at 850°C. The finished goods are used for the roofs of conveyer electric furnaces for firing enamels onto the ware.Translated from Ogneupory, No. 7, pp. 1–3, July, 1973. 相似文献
142.
Siarhei A. Dabravolski Victoria A. Khotina Vasily N. Sukhorukov Vladislav A. Kalmykov Liudmila M. Mikhaleva Alexander N. Orekhov 《International journal of molecular sciences》2022,23(2)
Cardiovascular diseases (CVD) are one of the leading causes of morbidity and mortality worldwide. mtDNA (mitochondrial DNA) mutations are known to participate in the development and progression of some CVD. Moreover, specific types of mitochondria-mediated CVD have been discovered, such as MIEH (maternally inherited essential hypertension) and maternally inherited CHD (coronary heart disease). Maternally inherited mitochondrial CVD is caused by certain mutations in the mtDNA, which encode structural mitochondrial proteins and mitochondrial tRNA. In this review, we focus on recently identified mtDNA mutations associated with CVD (coronary artery disease and hypertension). Additionally, new data suggest the role of mtDNA mutations in Brugada syndrome and ischemic stroke, which before were considered only as a result of mutations in nuclear genes. Moreover, we discuss the molecular mechanisms of mtDNA involvement in the development of the disease. 相似文献
143.
Siarhei A. Dabravolski Alexander D. Zhuravlev Andrey G. Kartuesov Evgeny E. Borisov Vasily N. Sukhorukov Alexander N. Orekhov 《International journal of molecular sciences》2022,23(10)
Several recent cardiovascular trials of SGLT 2 (sodium-glucose cotransporter 2) inhibitors revealed that they could reduce adverse cardiovascular events in patients with T2DM (type 2 diabetes mellitus). However, the exact molecular mechanism underlying the beneficial effects that SGLT2 inhibitors have on the cardiovascular system is still unknown. In this review, we focus on the molecular mechanisms of the mitochondria-mediated beneficial effects of SGLT2 inhibitors on the cardiovascular system. The application of SGLT2 inhibitors ameliorates mitochondrial dysfunction, dynamics, bioenergetics, and ion homeostasis and reduces the production of mitochondrial reactive oxygen species, which results in cardioprotective effects. Herein, we present a comprehensive overview of the impact of SGLT2 inhibitors on mitochondria and highlight the potential application of these medications to treat both T2DM and cardiovascular diseases. 相似文献
144.
145.
Siarhei A. Dabravolski Evgeny E. Bezsonov Mirza S. Baig Tatyana V. Popkova Ludmila V. Nedosugova Antonina V. Starodubova Alexander N. Orekhov 《International journal of molecular sciences》2021,22(9)
NAFLD (non-alcoholic fatty liver disease) is a widespread liver disease that is often linked with other life-threatening ailments (metabolic syndrome, insulin resistance, diabetes, cardiovascular disease, atherosclerosis, obesity, and others) and canprogress to more severe forms, such as NASH (non-alcoholic steatohepatitis), cirrhosis, and HCC (hepatocellular carcinoma). In this review, we summarized and analyzed data about single nucleotide polymorphism sites, identified in genes related to NAFLD development and progression. Additionally, the causative role of mitochondrial mutations and mitophagy malfunctions in NAFLD is discussed. The role of mitochondria-related metabolites of the urea cycle as a new non-invasive NAFLD biomarker is discussed. While mitochondria DNA mutations and SNPs (single nucleotide polymorphisms) canbe used as effective diagnostic markers and target for treatments, age and ethnic specificity should be taken into account. 相似文献
146.
147.
Nina Kubatova Dennis J. Pyper Dr. Hendrik R. A. Jonker Dr. Krishna Saxena Laura Remmel Dr. Christian Richter Dr. Sabine Brantl Prof. Dr. Elena Evguenieva-Hackenberg Prof. Dr. Wolfgang R. Hess Prof. Dr. Gabriele Klug Prof. Dr. Anita Marchfelder Prof. Dr. Jörg Soppa Prof. Dr. Wolfgang Streit Dr. Maxim Mayzel Prof. Dr. Vladislav Y. Orekhov Prof. Dr. Monika Fuxreiter Prof. Dr. Ruth A. Schmitz Prof. Dr. Harald Schwalbe 《Chembiochem : a European journal of chemical biology》2020,21(8):1178-1187
Proteins encoded by small open reading frames (sORFs) have a widespread occurrence in diverse microorganisms and can be of high functional importance. However, due to annotation biases and their technically challenging direct detection, these small proteins have been overlooked for a long time and were only recently rediscovered. The currently rapidly growing number of such proteins requires efficient methods to investigate their structure–function relationship. Herein, a method is presented for fast determination of the conformational properties of small proteins. Their small size makes them perfectly amenable for solution-state NMR spectroscopy. NMR spectroscopy can provide detailed information about their conformational states (folded, partially folded, and unstructured). In the context of the priority program on small proteins funded by the German research foundation (SPP2002), 27 small proteins from 9 different bacterial and archaeal organisms have been investigated. It is found that most of these small proteins are unstructured or partially folded. Bioinformatics tools predict that some of these unstructured proteins can potentially fold upon complex formation. A protocol for fast NMR spectroscopy structure elucidation is described for the small proteins that adopt a persistently folded structure by implementation of new NMR technologies, including automated resonance assignment and nonuniform sampling in combination with targeted acquisition. 相似文献
148.
Siarhei A. Dabravolski Vasily N. Sukhorukov Vladislav A. Kalmykov Nikolay A. Orekhov Andrey V. Grechko Alexander N. Orekhov 《International journal of molecular sciences》2022,23(2)
Cardiovascular diseases (CVDs) are the leading cause of death globally, representing approximately 32% of all deaths worldwide. Molecular chaperones are involved in heart protection against stresses and age-mediated accumulation of toxic misfolded proteins by regulation of the protein synthesis/degradation balance and refolding of misfolded proteins, thus supporting the high metabolic demand of the heart cells. Heat shock protein 90 (HSP90) is one of the main cardioprotective chaperones, represented by cytosolic HSP90a and HSP90b, mitochondrial TRAP1 and ER-localised Grp94 isoforms. Currently, the main way to study the functional role of HSPs is the application of HSP inhibitors, which could have a different way of action. In this review, we discussed the recently investigated role of HSP90 proteins in cardioprotection, atherosclerosis, CVDs development and the involvements of HSP90 clients in the activation of different molecular pathways and signalling mechanisms, related to heart ageing. 相似文献
149.
Siarhei A. Dabravolski Victoria A. Khotina Andrey V. Omelchenko Vladislav A. Kalmykov Alexander N. Orekhov 《International journal of molecular sciences》2022,23(2)
The vascular endothelial growth factor (VEGF) family, the crucial regulator of angiogenesis, lymphangiogenesis, lipid metabolism and inflammation, is involved in the development of atherosclerosis and further CVDs (cardiovascular diseases). This review discusses the general regulation and functions of VEGFs, their role in lipid metabolism and atherosclerosis development and progression. These functions present the great potential of applying the VEGF family as a target in the treatment of atherosclerosis and related CVDs. In addition, we discuss several modern anti-atherosclerosis VEGFs-targeted experimental procedures, drugs and natural compounds, which could significantly improve the efficiency of atherosclerosis and related CVDs’ treatment. 相似文献
150.
We propose to detect hidden photons (HPs) by using single electrons emitted from the surface of a metal cathode under the action of HPs of cold dark matter. A multiwire gas-discharge proportional counter of special design with four cathodes has been developed. Calibration measurements were performed for determining the efficiency of counting single electrons. Single-electron pulse counting rate in various detector configurations was measured. The upper limits of mixing parameter χ, which characterizes the kinetic mixing of HPs and ordinary photons, are estimated.
相似文献