Parents’ perceptions of the family climate for road safety

The current study examined the applicability of the Family Climate for Road Safety Scale (FCRSS; Taubman-Ben-Ari and Katz-Ben-Ami, 2013) to the parents of young drivers. The sample consisted of 549 parents and 234 of their children, all of whom completed the FCRSS. In addition, the parents completed the multidimensional driving style inventory (MDSI; Taubman-Ben-Ari et al., 2004) and provided background data (e.g., age, gender). Confirmatory factor analysis supported a slightly modified structure of the scale for parents. Examination of the correlations revealed significant weak to strong associations between parents’ scores on the various FCRSS dimensions on the one hand, and their self-reported driving styles and offspring’s perceptions of the family climate for safety on the other. The findings indicate that the FCRSS is suitable for use with the parents of young drivers, and that perceptions of the family climate are shared by the two generations. Furthermore, they show that family climate is related to parents’ customary driving behavior, with the careful driving style positively related to the positive dimensions of the FCRSS. The discussion stresses the importance of the parents’ influence on the manner in which their children drive, and the multifaceted nature of this influence. Moreover, it indicates the potential value of the FCRSS, both for research and for designing interventions and measuring their effectiveness.     

Work-based predictors of mortality: A 20-year follow-up of healthy employees.

Objectives: This study investigated the effects of the Job-Demand-Control-Support (JDC-S) model's components, workload, control, peer and supervisor social support, on the risk of all-cause mortality. Also examined was the expectation that the above work-based components interact in predicting all-cause mortality. The study's hypotheses were tested after controlling for physiological variables and health behaviors known to be risk factors for mortality. Main Outcome Measure: The design used was prospective. Baseline data were obtained from healthy employees (N = 820) who underwent periodic health examinations in 1988. Follow-up data on all-cause mortality were obtained from the participants' computerized medical file, kept by their HMO, in 2008. The baseline data covered socioeconomic, behavioral, and biological risk factors in addition to the components of the JDC-S model. During the period of follow-up, 53 deaths were recorded. Data were analyzed using Cox regressions. Results: Only one main effect was found: the risk of mortality was significantly lower for those reporting high levels of peer social support. The study found two significant interactions. Higher levels of control reduced the risk of mortality for the men and increased it for the women. The main effect of peer social support on mortality risk was significantly higher for those whose baseline age ranged from 38 to 43 but not for the older than 43 or the younger than 38 participants. Conclusion: Peer social support is a protective factor, reducing the risk of mortality, while perceived control reduces the risk of mortality among men but increases it among women. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Neuroprotective Effect of Nerve Growth Factor Loaded in Porous Silicon Nanostructures in an Alzheimer's Disease Model and Potential Delivery to the Brain

Nerve growth factor (NGF) plays a vital role in reducing the loss of cholinergic neurons in Alzheimer's disease (AD). However, its delivery to the brain remains a challenge. Herein, NGF is loaded into degradable oxidized porous silicon (PSiO₂) carriers, which are designed to carry and continuously release the protein over a 1 month period. The released NGF exhibits a substantial neuroprotective effect in differentiated rat pheochromocytoma PC12 cells against amyloid‐beta (Aβ)‐induced cytotoxicity, which is associated with Alzheimer's disease. Next, two potential localized administration routes of the porous carriers into murine brain are investigated: implantation of PSiO₂ chips above the dura mater, and biolistic bombardment of PSiO₂ microparticles through an opening in the skull using a pneumatic gene gun. The PSiO₂‐implanted mice are monitored for a period of 8 weeks and no inflammation or adverse effects are observed. Subsequently, a successful biolistic delivery of these highly porous microparticles into a live‐mouse brain is demonstrated for the first time. The bombarded microparticles are observed to penetrate the brain and reach a depth of 150 µm. These results pave the way for using degradable PSiO₂ carriers as potential localized delivery systems for NGF to the brain.     

NIR Fluorogenic Dye as a Modular Platform for Prodrug Assembly: Real‐Time in vivo Monitoring of Drug Release

The ability to monitor drug release in vivo provides essential pharmacological information. We developed a new modular approach for the preparation of theranostic prodrugs with a turn‐ON near‐infrared (NIR) fluorescence mode of action. The prodrugs release their chemotherapeutic cargo and an active cyanine fluorophore upon reaction with a specific analyte. The prodrug platform is based on the fluorogenic dye QCy7; upon removal of a triggering substrate, the dye fluoresces, and the free drug is released. The evaluated camptothecin prodrug was activated by endogenous hydrogen peroxide produced in tumor cells in vitro and in vivo. Drug release and in vitro cytotoxicity were correlated with the emitted fluorescence. The prodrug activation was effectively imaged in real time in mice bearing tumors. The modular design of the QCy7 fluorogenic platform should allow the preparation of numerous other prodrugs with various triggering substrates and chemotherapeutic agents. We anticipate that the development of real‐time in vivo monitoring tools such as that described herein will pave the way for personalized therapy.     

An Engineered Nanocomplex with Photodynamic and Photothermal Synergistic Properties for Cancer Treatment

Photodynamic therapy (PDT) and photothermal therapy (PTT) are promising therapeutic methods for cancer treatment; however, as single modality therapies, either PDT or PTT is still limited in its success rate. A dual application of both PDT and PTT, in a combined protocol, has gained immense interest. In this study, gold nanoparticles (AuNPs) were conjugated with a PDT agent, meso-tetrahydroxyphenylchlorin (mTHPC) photosensitizer, designed as nanotherapeutic agents that can activate a dual photodynamic/photothermal therapy in SH-SY5Y human neuroblastoma cells. The AuNP-mTHPC complex is biocompatible, soluble, and photostable. PDT efficiency is high because of immediate reactive oxygen species (ROS) production upon mTHPC activation by the 650-nm laser, which decreased mitochondrial membrane potential (^∆ψ_m). Likewise, the AuNP-mTHPC complex is used as a photoabsorbing (PTA) agent for PTT, due to efficient plasmon absorption and excellent photothermal conversion characteristics of AuNPs under laser irradiation at 532 nm. Under the laser irradiation of a PDT/PTT combination, a twofold phototoxicity outcome follows, compared to PDT-only or PTT-only treatment. This indicates that PDT and PTT have synergistic effects together as a combined therapeutic method. Our study aimed at applying the AuNP-mTHPC approach as a potential treatment of cancer in the biomedical field.     

The affective component of the secure base schema: Affective priming with representations of attachment security.

Using an affective priming procedure (S. T. Murphy & R. B. Zajonc, 1993), 7 studies examined the effects of the contextual activation of representations of attachment security (secure base schema) on the evaluation of neutral stimuli under either neutral or stressful contexts. In all the studies, participants also reported on their attachment style. Results indicated that the subliminal priming of secure base representations led to more positive affective reactions to neutral stimuli than did the subliminal priming of neutral or no pictures under both neutral and stressful contexts. Although the subliminal priming of positively valued, attachment-unrelated representations heightened positive evaluations under neutral contexts, it failed to elicit positive affect under stressful contexts. The results also revealed interesting effects of attachment style. The discussion focuses on the affective component of the secure base schema. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The contribution of family climate for road safety and social environment to the reported driving behavior of young drivers

Two studies examined the contribution of the new concept of “family climate for road safety” and several aspects of the social environment to the driving behavior of young drivers. Study 1 (n = 120) investigated the effect of the seven dimensions of the family climate for road safety – Modeling, Feedback, Communication, Monitoring, Noncommitment, Messages, and Limits – as well as a general tendency to conform to authority, and peer pressure. Study 2 (n = 154) examined the dimensions of family climate for road safety and perceived popularity of reckless driving among peers. The findings indicate associations both between the familial and the social aspects, and between these variables and driving styles, willingness to take risks while driving, reckless driving habits, and personal commitment to safe driving. Positive aspects of the parent–child relationship and high levels of conformity to authority were related to greater endorsement of the careful driving style, whereas family's noncommitment to safety, higher peer pressure, and lower conformity to authority were associated with greater endorsement of the reckless driving style. In addition, positive aspects of the family climate for road safety and lower perceived popularity of reckless driving among friends were associated with more personal commitment to safe driving and a lower tendency for risky driving. The discussion stresses the need to look at the complex set of antecedents of reckless driving among young drivers and addresses the practical implications of the findings for road safety.     

The effects of positive emotion priming on self-reported reckless driving

Five studies examined the effects of positive emotion priming on the willingness to drive recklessly. In all five, young drivers were exposed to one of the following primes of positive affect: a positive mood story; happy memories; an exciting film; a relaxing film; or thoughts on the meaning in life. Following the prime, the participants were asked to report on their willingness to drive recklessly. The responses were compared to those of groups exposed either to neutral affect, another kind of positive affect, or negative affect priming. In two of the studies, participants were also asked to report on their driving styles (risky, anxious, angry, or careful) as a second dependent variable. Positive affect, especially in the form of arousal, was found to be related to higher willingness to drive recklessly. Although men tended to report higher intentions to drive recklessly, men and women did not react differently to the emotional induction. Most interestingly, positive emotions of a relaxing nature, as well as thinking about the meaning in life, lowered the willingness to engage in risky driving. The discussion emphasizes the importance of looking for new ways to use positive emotions effectively in road safety interventions, and considers the practical implications of the studies.     

The contribution of perceived parental and familial characteristics to attitudes toward accompanied driving among young drivers

One of the main requirements of the graduated driving licensing system in Israel is that new drivers be accompanied by an experienced driver (usually one of their parents) for the first three months after receipt of their license. The current series of studies examined the associations between young drivers’ attitudes toward accompanied driving (ATAD) and their perception of their parents’ driving styles and parenting modes, as well as dynamic of their family. Young drivers completed questionnaires assessing their ATAD, and either perceived parental driving style (Study 1, n = 100), perceived parenting style (Study 2, n = 120), or perceived family dynamic (Study 3, n = 254). The results indicated significant associations between the young drivers’ ATAD of tension, relatedness, avoidance, disapproval, and anxiety, and their own perceptions of the characteristic driving styles of their parents (risky, anxious, angry, and careful). They also indicated significant relationship between youngsters’ ATAD and their perceptions of their parents’ parenting modes (responsive, demanding, and autonomy-granting). Finally, the results indicated significant negative associations between ATAD of tension, avoidance, disapproval, and anxiety, and family cohesion and adaptability, and a positive association between these two and relatedness. The results are discussed in respect to the relationship between the parental model and the young drivers’ ATAD in particular, and risk management in general, and practical implications of these results are offered.     

The consequences of doing nothing: Inaction inertia as avoidance of anticipated counterfactual regret.

When an attractive action opportunity has been forgone, individuals tend to decline a substantially less attractive current opportunity in the same action domain, even though, in an absolute sense, it still has positive value. The hypothesis that continued inaction (inaction inertia) occurs in the service of avoiding anticipated regret was tested. In Experiments 1 and 2, when repeated contact with the forgone opportunity (and, hence, the experience of regret) was made unavoidable, the tendency toward subsequent inaction decreased. The inaction inertia effect was also reduced when avoidance costs were increased (Experiment 3) or when the initial reason for avoidance was removed (Experiment 4). Experiment 4 included a thought-listing task that provided direct evidence for the role of regret in producing inaction inertia. (PsycINFO Database Record (c) 2010 APA, all rights reserved)