Retrospective evaluation of cardiopulmonary and acid-base variables during long-term balanced anesthesia for experimental surgery in dogs

Cardiopulmonary and acid-base variables recorded during long-term balanced anesthesia lasting between 12.5 and 16.9 h were evaluated retrospectively in 15 healthy foxhounds that underwent experimental bulla osteotomy with implantation of hearing aids. After premedication with propionylpromazine (0.11 +/- 0.02 mg/kg of body weight) and L-methadone (0.71 +/- 0.06 mg/kg) intravenously (i.v.) and induction with pentobarbital sodium (6.02 +/- 0.83 mg/kg i.v.), anesthesia was maintained with halothane (end-tidal concentration; ETHAL: 0.4 to 1.5%) in nitrous oxide (2 L/min) and oxygen (1 L/min). Because of positional changes from sternal to right lateral recumbency after presurgical brain stem electric response audiometry and differences in duration of surgery, data obtained between 4 (baseline) and 14 h after induction of anesthesia were analyzed. Arterial (PaO2) and alveolar (PAO2) O2 tensions, arterial-to-alveolar O2 tension ratio (PaO2/PAO2), and arterial O2 content (CaO2) remained relatively stable throughout anesthesia. Arterial carbon dioxide tension (PaCO2) was significantly increased above baseline (39, 33 to 46 mm Hg [median, range]) between 7 (39.8, 36.5 to 48.9 mm Hg) and 9 (42, 37.5 to 49.5 mm Hg) h after induction. Because changes in PaCO2 were accompanied by significant increases in body temperature from baseline (36.3, 34.6 to 37.4 degrees C) between 8 (37.1, 35 to 38 degrees C) and 11 (37.6, 35.3 to 38.1 degrees C) h after anesthesia induction as well as by slight increases in arterial blood pressure, the PaCO2 increase may have been caused by increase in metabolic CO2 production and enhanced drainage of CO2 from the tissues into systemic circulation. Furthermore, mild metabolic acidosis (pHa: 7.31, 7.26 to 7.38; HCO3-: 18.9, 16.7 to 21.8 mEq/L; base deficit [BD]: -6.3, -8.5 to -3.4 mEq/L) already existed at 4 h after induction and was related in part to tissue hypoperfusion. Small increases in pHa during the course of anesthesia were accompanied by significant increases in HCO3- concentration and significant decreases in BD between 5 and 10 h after induction. Minor circumscribed swelling of the dependent triceps or masseter muscle was noticed on the first postoperative day in two dogs, and marked tissue swelling with hematoma formation at the medial side of one hind limb was noticed in a third dog. All dogs recovered completely and were submitted to follow-up studies. The anesthetic protocol and extent of monitoring used were adequate to provide safe long-term anesthesia for an experimental surgical procedure with a 100% survival rate and uneventful recovery in most of the dogs.     

Application of fracture mechanics to nuclear piping systems

With the introduction of Nuclear Energy into the power industry, rigid requirements for the design of piping have been set up to prevent accidents that may cause dangers to the health and safety of the public. Of particular concern is the rupture of a pipe. In this paper, nuclear piping systems are examined from a fracture mechanics viewpoint considering present day ASME code standards. Included are calculations of the critical crack length for a typical piping system. A brief discussion of the pipe whip phenomenon is also given.     

Regaining control: Understanding compensation behavior and coping with variable interval partial reinforcement.

Patients pursuing claims or causes within bureaucratic, administrative, or legal systems present special problems to therapists. Encounters with systems such as the Veterans Compensation System, Social Security, Workers Compensation, and the courts may cause patients to lose some control over their lives and therapists to be perplexed, uneasy, and challenged as to how to intervene therapeutically. This article shows how variable interval partial reinforcement can partly explain these patient problems. Veteran cases are the main examples, but nonveteran cases are discussed. Interventions that therapists may use to help patients regain control are suggested. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Rate of improvement during cognitive-behavioral group treatment for panic disorder

This study examined the rate of symptom improvement in patients receiving cognitive-behavioral group treatment for panic disorder in an outpatient clinic setting. Treatment was a standard program of 12 sessions that emphasized information, interoceptive and situational exposure, and cognitive restructuring, but also included diaphragmatic breathing and relaxation training as elements of treatment. Subjects were 37 patients selected from sequential admissions into an outpatient treatment program; all data were derived from ongoing quality assurance measures that are a standard part of clinical monitoring. Consequently, this study provides data not on the relative efficacy of cognitive-behavioral therapy (CBT), but on rate of improvement and effectiveness of CBT for panic disorder in actual clinical practice. Patients achieved significant treatment gains on all panic disorder dimensions assessed, and the largest reduction in symptoms was during the first third of the treatment program, thereby challenging the notion that CBT delivers its gains slowly over time. Information on rats of symptom improvement is valuable for providing patients with accurate expectations about potential treatment benefits and for helping to maintain motivation during initial treatment sessions.     

Influences of chorion type on saccadic eye movements in twins

PURPOSE: The influence of genetic and prenatal environmental factors on characteristics of saccadic performance were evaluated in young monozygotic (MZ) twins (8-19 years old) of known chorion type. METHODS: Saccadic eye movements were recorded using an infrared system. Saccadic latency, accuracy, and parameters of amplitude-peak velocity exponential equation (main sequence) were quantified. RESULTS: Intraclass correlations of saccadic parameters differed significantly from zero for monochorionic and dichorionic MZ twins. The within-pair mean squares were significantly less, and intraclass correlations were significantly higher in monochorionic than in dichorionic twins for latency and were similar for other saccadic parameters (accuracy, slope of main sequence, and peak velocity for 15 degrees saccades). CONCLUSIONS: These findings confirmed previous reports that saccadic parameters of MZ twins are significantly correlated and indicated that similarity of these parameters seen in MZ twins may be driven both by genetic and by prenatal environmental factors.     

Analysis of plastic flow localization under strain paths changes and its coupling with finite element simulation in sheet metal forming

Formability of sheet metal is usually assessed by the useful concept of forming limit diagrams (FLD) and forming limit curves (FLC) represent a first safety criterion for deep drawing operations. The level of FLC is strongly strain path dependent as observed by experimental and numerical results and therefore non-proportional strain paths need to be incorporated when analyzing formability of sheet metal components. Simulations using finite element method allow accurate predictions of stress and strain distributions in complex stamped parts. However, the prediction of localized necking is a difficult task and the combination of forming limit diagram analysis with finite element simulations often fail to give the right answer, if complex strain paths are not included in these predictions.     

Purification of peroxidase isoenzymes from turnip roots

Simple reproducible procedures for purification of the main soluble (S) and ionically bound (IB) cationic peroxidase isoenzymes from turnip roots were established. The procedures included ammonium sulfate precipitation of the isoenzymes, chromatographic separation of the main isoenzymes using cellulose phosphate columns and purification to homogeneity by hydrophobic interaction chromatography on phenyl Sepharose columns. The specific activity of the phenyl Sepharose purified S and IB isoenzymes were 2760 and 896 units/mg protein with 140 and 4.8 fold increase over the crude extract and 38 and 13% recovery. The pH maxima and K(m) for phenol and H2O2 of purified S and IB were determined.     

Simulation models for the analysis of space heat consumption of buildings

This study develops and analyzes an original methodology for the simulation and prediction of space heating energy consumption in buildings connected to a district heating system, characterized by lack of individual control systems for end-users. The identification of the input parameters is based on both classical engineering equations and statistical analysis of collected data. Two main factors play important roles in the model: (i) climate and (ii) human behavior. Model validation was undertaken through the analysis of field data collected during the winter, via a monitoring system working in a partially-controlled district heating system. The comparison between the results obtained with the proposed model versus classical methods points out the possibility to implement, using the proposed methodology, management policies for a district that offer significant cost-effective energy savings opportunities.