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41.
We have isolated an insertional mutant of Dictyostelium discoideum that aggregated rapidly and formed spores and stalk cells within 14 h of development instead of the normal 24 h. We have shown by parasexual genetics that the insertion is in the rdeA locus and have cloned the gene. It encodes a predicted 28 kDa protein (RdeA) that is enriched in charged residues and is very hydrophilic. Constructs with the DNA for the c-Myc epitope or for the green fluorescent protein indicate that RdeA is not compartmentalized. RdeA displays homology around a histidine residue at amino acid 65 with members of the H2 module family of phosphotransferases that participate in multistep phosphoryl relays. Replacement of this histidine rendered the protein inactive. The mutant is complemented by transformation with the Ypd1 gene of Saccharomyces cerevisiae, itself an H2 module protein. We propose that RdeA is part of a multistep phosphorelay system that modulates the rate of development. 相似文献
42.
43.
44.
Otto Richter Thomas Schmidt Hand Büning-Pfaue und Dietrich Reinhardt 《Zeitschrift für Lebensmitteluntersuchung und -Forschung A》1988,187(2):130-136
Zusammenfassung Es werden pharmakokinetische Modelle angegeben, um den Konzentrationsverlauf von Arzneimittelrückständen im Menschen zu berechnen, die mit der Nahrung aufgenommen werden. Dabei lassen sich zwei Kompartimentmodelle für die Kinetik in der Nahrung und im Menschen koppeln: Das erste System liefert die Anfangswerte (bzw. eine Folge von Anfangswerten) für das zweite System. Das Modell wird auf die Übertragung von Chloramphenicol durch Speisefische auf den Menschen und auf die Übertragung von Theophyin durch die Muttermilch auf gestillte Säuglinge angewendet. Durch Einführung einer günstigsten und ungünstigsten Parameterkombination werden Grenzverläufe für die Blutspiegel berechnet, die als Grundlage einer Rückstandsbewertung dienen können.
Residues of active substances following the consumption of contaminated food —Status report on the evaluation of residues based on two drugs
Summary Pharmacokinetic models are presented for the computation of time courses of blood levels of drugs in man following the consumption of contaminated food. Mathematically, two linear systems of differential equations are set up for the donor organism (e.g., trout) and for the recipient, (e.g., man), where the first system generates the initial conditions for the second. Models of this kind are applied to the transfer of chloramphenicol to man via carp and trout (which had previously been administered this drug) and to the transfer of theophylline to infants via breast milk. Limiting concentration profiles are computed by constructing the most favourable and most adverse combinations of parameters with respect to drug elimination in both the donor and recipient organism.相似文献
45.
Current Research Activities
The Swedish approach to research and development in fire protection 相似文献46.
Summary The throughput of a satellite channel communication is depending upon the link protocol. It is well known that the classical HDLC protocol is inadequate when applied to satellite links instead of short terrestrial links. Several modifications have been proposed to overcome this problem. The present paper gives an analysis and evaluation of a new class of protocols called Virtual Subchannel schemes which splits the satellite link into several components; these subchannels are assigned for transmission in cyclic order and are controlled independently of each other by the classical HDLC procedure. 相似文献
47.
Friedrich Otto 《Theory of Computing Systems》1987,20(1):253-260
WhenC is a concurrency relation on alphabet , then */=
C
is a free partially commutative monoid. Here we show that it is decidable in polynomial time whether or not there exists a finite canonical rewriting systemR on such that the congruences
R
*
generated byR and =
C
induced byC coincide. Further, in case such a systemR exists, one such system can be determined in polynomial time. 相似文献
48.
Dirk Anderheiden Otto Brenner Doris Klee Robert Kaufmann Horst A. Richter Christian Mittermayer Hartwig Hcker 《大分子材料与工程》1991,185(1):109-127
Different polyurethanes were synthesized by varying the diol as well as the diisocyanate components and chain extenders. Polyurethanes with OH-groups were obtained by photo- and thermoinitiation of the radical polymerization of hydroxy alkyl acrylates in the presence of the polyurethanes. The polymers were evaluated with respect to their biocompatibility by measuring the cell spreading, the rates of DNA- and protein synthesis and the swelling behaviour. The differences in the surfaces and the bulks between the selected basic polyurethane and the functionalized modification were determined and characterized by XPS, FTIR-ATR and 13C-FT-NMR-spectroscopy. The mechanical data of Tecoflex EG 60D® and Pellethane 2363–80AE® were compared with the data of the synthesized polyurethanes. 相似文献
49.
On Cu-ZSM-5 zeolite at room temperature, propane is physisorbed, while propene shows characteristics of chemisorption. The chemisorption mode has certain advantages for the catalytic control of automotive emissions. Alkane and alkene adsorption equilibria and kinetics are compared on Cu-ZSM-5 and on ZSM-5 free of alumina. The results are discussed in terms of the Langmuir adsorption isotherm. 相似文献
50.
Earlier studies have shown that sulfur dioxide and metal-support interaction can strongly influence propane oxidation over platinum. In particular, oxidation activity is enhanced when platinum is supported on sulfated -alumina or zirconia compared to -alumina. Therefore, it is of interest to compare the performance of palladium under the same experimental conditions. Four model catalysts were examined: Pt/-alumina, Pt/zirconia, Pd/-alumina and Pd/zirconia. The metal loading was kept at or below 0.05 wt% to emphasize changes in activity attributable to metal-support interaction. Reaction rates were measured with and without sulfur dioxide. Surface sulfation was analyzed by measuring acid strength and evaluating spectra obtained by Fourier-transform infrared spectroscopy. In contrast to platinum, sulfation does not promote propane oxidation on Pd/-alumina, and Pd/zirconia is less active than Pd/-alumina. 相似文献