Reexamination of the Ergothioneine Biosynthetic Methyltransferase EgtD from Mycobacterium tuberculosis as a Protein Kinase Substrate

Ergothioneine has emerged as a crucial cytoprotectant in the pathogenic lifestyle of Mycobacterium tuberculosis. Production of this antioxidant from primary metabolites may be regulated by phosphorylation of Thr213 in the active site of the methyltransferase EgtD. The structure of mycobacterial EgtD suggests that this post-translational modification would require a large-scale change in conformation to make the active-site residue accessible to a protein kinase. In this report, we show that, under in vitro conditions, EgtD is not a substrate of protein kinase PknD.     

Optimal weighed Holoentropy for video compression: an advanced HEVC

ABSTRACT

In recent times, the applications of multimedia are rising in a greedy mode and hence the amount of video transactions is also increasing exponentially. This has shouted great demands on effective models on video encoding and also for reducing the transmission channel congestion. This research work introduces a managing technique termed weighted encoding for High-Efficiency Video Coding (HEVC). HEVC, also termed as MPEG-H Part 2 and H.265 is a video compression standard that is widely utilized AVC (H.264 or MPEG-4 Part 10). When compared to AVC, HEVC grants double the ratio of data compression at a similar level of quality of the video or considerably enhanced video quality at a similar bit rate. This work intends to optimize the weight that adopted in HEVC for encoding. For this, this paper proposes a new Iterative based propagation update in the water wave Optimization Algorithm (IPU-WWO), which is the improved form of Water wave Optimization (WWO). The performance of proposed IPU-WWO is compared over other conventional methods like Artificial Bee Colony (ABC), Firefly (FF), Particle Swarm Optimization (PSO) and Genetic Algorithm (GA) with respect to Peak Signal to Noise Ratio (PSNR). By doing the encoding process, it minimizes the video size with perceptually better quality video or PSNR.     

Shaping the Toroidal Section of End Mills

The shaping of the toroidal cutting section of end mills is considered. Methods are devised for selecting the positional parameters in shaping the helical rake surface on the toroidal section. Relations are established between the geometric parameters of the end mill in the toroidal section.     

Optimizing the tapping regime on a blast furnace operating at variable speed

The main factors that determine the uniformity with which smelting products are tapped from a blast furnace are the rate of accumulation of the products in the hearth and the tapping rate. The first parameter is in turn determined by the stability of the furnace’s operation and can vary significantly even over the course of 24 h. The second parameter is determined mainly by the condition of the iron notch, the maintenance it receives, any changes that occur in the diameter of the channel of the notch, and the quality of the materials used to form the notch. Recommendations are presented to optimize tapping of the smelting products.     

Volumetric out-of-furnace heat treatment of 3600-M3 decomposers

Specifications require that all the welds in 12-m-diam. decomposers with a capacity of 3600 m³ be subjected to high-temperature tempering before going into service in order to alleviate the stresses from the welding operation. Specialists at the organizations VNIIPTkhimnefteapparatury and VNIImontazhspetsstroi have proposed out-of-furnace volumetric (complete) of the assembled decomposer with the use of special heaters. The use of this heating method has shortened assembly operations while providing the welds with a highquality heat treatment and reducing the stresses overall (including welding stresses, stresses from assembly of the decomposer, etc.) The technology ensures uniform heating of the housing of the decomposer and provides for close control over the process. The experience gained in heat-treating decomposers can also be used in the construction of other containers that come into contact with corrosive media. __________ Translated from Metallurg, No. 3, pp. 61–64, March, 2006.     

Convergence and trust in eCommerce

Trust is the key element of commerce, both for traditional models and — more recently — for eCommerce. Unlike its traditional counterpart, eCommerce relies on trust being created and maintained with the help of digital devices and services. Convergence brings significant changes to the way people interact through digital media by offering ubiquitous and seamless communication. This has a significant impact on the way trust is established and maintained, with consequent impact upon eCommerce. This paper identifies a number of the most important challenges to trust in eCommerce as well as trust-related aspects of key enablers of eCommerce. From this perspective, the paper studies an impact of convergence on trust within eCommerce to identify several positive relationships.     

An inventory analysis of rural pollution loads in China.

Rural pollution has attracted increasing attention over the past decade for its important consequences on surface and groundwater quality. This is particularly so in China due to the wide and effective control of industrial and municipal wastewater discharges over the past decade. Based on the discussion of rural activities in China, this paper develops a new method of inventory analysis through the definition of elementary unit (EU). This inventory analysis approach is then applied to estimate the total rural pollution loads of COD, TN and TP, as well as their spatial distributions in China. Further analysis is also conducted to investigate the correlations between rural pollution loads and agricultural production outputs, as well as population. It is found that China's agriculture is developing largely at the cost of environment quality, and a high population, as well as the increasing demand for agricultural products, is one of the dominant driving forces. The constructed EKC, which describes the relationship between rural pollution loads and agricultural income, also reveals that current agricultural development in China is mostly far from de-locked from the environmental problem.