A Modular Vaccine Platform Combining Self‐Assembled Peptide Cages and Immunogenic Peptides

Subunit vaccines use delivery platforms to present minimal antigenic components for immunization. The benefits of such systems include multivalency, self‐adjuvanting properties, and more specific immune responses. Previously, the design, synthesis, and characterization of self‐assembling peptide cages (SAGEs) have been reported. In these, de novo peptides are combined to make hubs that assemble into nanoparticles when mixed in aqueous solution. Here it is shown that SAGEs are nontoxic particles with potential as accessible synthetic peptide scaffolds for the delivery of immunogenic components. To this end, SAGEs functionalized with the model antigenic peptides tetanus toxoid_632‐651 and ovalbumin_323‐339 drive antigen‐specific responses both in vitro and in vivo, eliciting both CD4⁺ T cell and B cell responses. Additionally, SAGEs functionalized with the antigenic peptide hemagglutinin_518‐526 from the influenza virus are also able to drive a CD8⁺ T cell response in vivo. This work demonstrates the potential of SAGEs to act as a modular scaffold for antigen delivery, capable of inducing and boosting specific and tailored immune responses.     

10Gb XFP光模块的电路板设计

XFP MSA(10Gb小形状因数可插拔多源协议)组织定义了用于数据通信和电信的10Gbps串行收发器,该组织由数据通信行业和电信行业中处于领先地位的网络公司、系统公司、光模块公司、半导体公司以及连接器公司组成(参考文献1).     

Hillock and Whisker Growth on Sn and SnCu Electrodeposits on a Substrate Not Forming Interfacial Intermetallic Compounds

Intermetallic compound (IMC) formation at the interface between the tin (Sn) plating and the copper (Cu) substrate of electronic components has been thought to produce compressive stress in Sn electrodeposits and cause the growth of Sn whiskers. To determine if interfacial IMC is a requirement for whisker growth, bright Sn and a Sn-Cu alloy were electroplated on a tungsten (W) substrate that does not form interfacial IMC with the Sn or Cu. At room temperature, conical Sn hillocks grew on the pure Sn deposits and Sn whiskers grew from the Sn-Cu alloy electrodeposits. These results demonstrate that interfacial IMC is not required for initial whisker growth.     

Design and fabrication of monolithically integrated DFB laser-wavelength duplexer transceivers for TPON/BPON access links

The fabrication and characterisation of monolithically integrated OEIC transceivers for use in optical subscriber access links are reported. A design incorporating DFB lasers, wavelength duplexers and a monitor photodiode, specific to the TPON/BPON passive optical network configuration is presented.<>     

CW high power single-lobed far-field operation of long-cavityAlGaAs-GaAs single-quantum-well laser diodes grown by MOCVD

Data on long-cavity 100-μm-wide broad-stripe laser diodes that lase with a barrow single-lobed far-field pattern in continuous room-temperature operation are presented. Diodes with a cavity length of 1250 μm emit a power of 200 mW per facet into a 2.5° lobe (full width at half maximum). Short-cavity devices (cavity length of 350 μm) lase with a continuously increasing number of lateral modes right from threshold, and exhibit a far-field divergence that is over three times greater than that of 1250-μm diodes. Explanations for the effect of increasing cavity length on the field patterns of these devices are proposed, based on the measured increase in injected carrier diffusion length in long-cavity diodes and the influence of thermal waveguiding and mirror losses on intermodel discrimination     

Simulation, modeling, and crystal growth of Cd0.9Zn0.1Te for nuclear spectrometers

High-quality, large (10 cm long and 2.5 cm diameter), nuclear spectrometer grade Cd_0.9Zn_0.1Te (CZT) single crystals have been grown by a controlled vertical Bridgman technique using in-house zone refined precursor materials (Cd, Zn, and Te). A state-of-the-art computer model, multizone adaptive scheme for transport and phase-change processes (MASTRAP), is used to model heat and mass transfer in the Bridgman growth system and to predict the stress distribution in the as-grown CZT crystal and optimize the thermal profile. The model accounts for heat transfer in the multiphase system, convection in the melt, and interface dynamics. The grown semi-insulating (SI) CZT crystals have demonstrated promising results for high-resolution room-temperature radiation detectors due to their high dark resistivity (ρ≈2.8 × 10¹¹ Θ cm), good charge-transport properties [electron and hole mobility-life-time product, μτ_e≈(2–5)×10⁻³ and μτ_h≈(3–5)×10⁻⁵ respectively, and low cost of production. Spectroscopic ellipsometry and optical transmission measurements were carried out on the grown CZT crystals using two-modulator generalized ellipsometry (2-MGE). The refractive index n and extinction coefficient k were determined by mathematically eliminating the ∼3-nm surface roughness layer. Nuclear detection measurements on the single-element CZT detectors with ²⁴¹Am and ¹³⁷Cs clearly detected 59.6 and 662 keV energies with energy resolution (FWHM) of 2.4 keV (4.0%) and 9.2 keV (1.4%), respectively.     

Monolithically Integrated InP 1 $times$ 16 Optical Switch With Wavelength-Insensitive Operation

The static and dynamic characteristics of a monolithically integrated InP 1$,times,$ 16 optical phased-array switch are presented. The device demonstrates static switching with an average extinction ratio of 18.6 dB, on-chip loss below 7 dB, and wavelength dependence of less than 0.8 dB in the entire $C$-band. A 40-Gb/s nonreturn-to-zero signal is transmitted through the switch with a power penalty below 0.4 dB. Using a programmable electronic circuit, dynamic switching to all 16 outputs is achieved with response times less than 11 ns.      

Facile Synthesis of Red/NIR AIE Luminogens with Simple Structures,Bright Emissions,and High Photostabilities,and Their Applications for Specific Imaging of Lipid Droplets and Image‐Guided Photodynamic Therapy

Red/near‐infrared (NIR) fluorescent molecules with aggregation‐induced emission (AIE) characteristics are of great interest in bioimaging and therapeutic applications. However, their complicated synthetic approaches remain the major barrier to implementing these applications. Herein, a one‐pot synthetic strategy to prepare a series of red/NIR‐emissive AIE luminogens (AIEgens) by fine‐tuning their molecular structures and substituents is reported. The obtained AIEgens possess simple structures, good solubilities, large Stokes shifts, and bright emissions, which enable their applications toward in vitro and in vivo imaging without any pre‐encapsulation or ‐modification steps. Excellent targeting specificities to lipid droplets (LDs), remarkable photostabilities, high brightness, and low working concentrations in cell imaging application make them remarkably impressive and superior to commercially available LD‐specific dyes. Interestingly, these AIEgens can efficiently generate reactive oxygen species upon visible light irradiation, endowing their effective application for photodynamic ablation of cancer cells. This study, thus, not only demonstrates a facile synthesis of red/NIR AIEgens for dual applications in simultaneous imaging and therapy, but also offers an ideal architecture for the construction of AIEgens with long emission wavelengths.     

用于电源、继电器和螺线管的协同式线路保护

在各种新型先进设备上实施协同式电路保护可有助于提高设备可靠性、减少元器件数量,并使其符合严格的安规要求。协同式方法能够帮助保护电源、继电器和螺线管,避免因线路故障或过载造成电流增大以及尖峰电压或暴露在稳态过压状态带来的危害。     

Detecting Low-Power RF Signals Using a Multimode Optoelectronic Oscillator and Integrated Optical Filter

We have assembled and characterized a multimode optoelectronic oscillator with integrated optical filter for detecting low-power radio-frequency (RF) signals. The system can selectively amplify RF signals from 1 to 6 GHz. The input signals can be as low as $-$ 83 dBm with a compression dynamic range of 72 dB. Using an integrated silicon optical filter facilitates channelization of the amplified RF signal from 1 to 3 GHz by reducing the gain for signals above 3 GHz. Future system improvements are discussed.