Multiple-input microcantilever sensors

A surface-micromachined micro-electro-mechanical-system (MEMS) process has been used to demonstrate multiple-input chemical sensing using selectively coated cantilever arrays. Cantilever motion due to absorption-induced stress was readout using a custom-designed, eight-channel integrated circuit. Combined hydrogen and mercury vapor detection was achieved with a palm-sized, self-powered module with spread-spectrum telemetry reporting.     

The cortisol response to psychological stress in temporomandibular dysfunction

Recombinant antibody fragments can be produced in large quantities using bacterial expression systems and could potentially be useful for the generation of biofilters for the selective removal of viral particles from fluids. A human single chain-Fv antibody library, derived from synthetic repertoires of germ line VH-gene segments rearranged in vitro and paired to a single light chain (Nissim et al., 1994, EMBO J., 13, 692-698), has recently been used to isolate hundreds of different binding specificities by panning with antigen. Antibodies from this library typically have affinities in the 10(6)-10(7) M-1 range. Occasionally, better binders are isolated but at other times the affinities recovered are poor. In the latter situation binding cannot be detected with soluble antibodies, but only by high-avidity display of multiple copies of antibodies on phage. By panning with human cytomegalovirus (HCMV)-coated immunotubes, we have isolated a number of antibody clones from this library that bound to the antigen only if displayed on the filamentous phage, but not in soluble form. One of these clones was selected for an affinity maturation procedure, achieved by combinatorial mutagenesis of the complementarity determining region 3 (CDR3) of the antibody light chain, followed by selection of the resulting library for HCMV binding. By this means, we were able to isolate a number of binders, some of which exhibited specific HCMV binding in soluble form. The clone that gave the strongest ELISA signal was expressed in bacteria, purified in solution, characterised using a novel capture methodology with surface plasmon resonance detection on a BIAcore instrument and used for the production of an immunofilter for the removal of HCMV form human serum. The filter removed more than 99% of applied HCMV in 10 min circulation time, while the amount of HCMV retained non-specifically in a cartridge derivatised with a non-specific antibody was less than 10% under similar conditions.     

Stochastic aspects of bridge deck aeroelasticity under turbulent flow

Returning to an earlier frequency-domain analysis of the problem of long-span bridge response to ambient winds, the paper emphasizes the indispensable experimental information necessary to bring results into conformity with full-scale prototype action. Focus is placed upon the use of a sectional wind tunnel model under simulated turbulent flow as the prime source of this information, which consists principally of the flutter derivatives and the spectra of the wind forces, both obtained under turbulent flow. The effect of three-dimensional turbulence upon the flutter derivatives is observed to influence structural stability in a manner consistent with that observed in full-bridge wind tunnel models.     

Nanorod heterostructures showing photoinduced charge separation

Size- and shape-dependent property modifications of semiconductor nanocrystals have been a subject of intense interest because of their potential for future engineering devices. The bandgap and related optical-property tuning of these materials are mainly governed by the nature of their band edges. In addition, fusing one type of nanocrystal over another enables further control of material properties that are dependent on the relative alignments of their energy levels. On a molecular scale, the synthesis of supramolecular compounds has inspired advances in theories for photoinduced charge transfer. Heterostructured nanocrystals potentially provide a nanoscale analog of such systems. A method for preparing heterostructured nanocrystals of complex morphologies showing photoinduced charge separation is presented. It is shown that the energy and lifetime of the charge-transfer photoluminescence band can be tuned by changing the relative alignment of band edges in CdSe/CdTe heterostructure nanorods. The long-lived charge transfer states in these type II semiconductors may make them attractive for photovoltaic applications.     

Business intelligence success: The roles of BI capabilities and decision environments

This study examines the role of the decision environment in how well business intelligence (BI) capabilities are leveraged to achieve BI success. We examine the decision environment in terms of the types of decisions made and the information processing needs of the organization. Our findings suggest that technological capabilities such as data quality, user access and the integration of BI with other systems are necessary for BI success, regardless of the decision environment. However, the decision environment does influence the relationship between BI success and capabilities, such as the extent to which BI supports flexibility and risk in decision making.     

Contrast-based evaluation of mar resistance of thermoplastic olefins

The physical aspect of mar behavior is studied by applying a standardized progressive sliding load methodology to smooth and textured automotive-grade thermoplastic olefins. It is shown that surface texture has a strong effect on light scattering and, hence, the propensity for mar visibility. It is also shown that digital imaging via a desktop scanner can be used to quantitatively and objectively assess mar resistance using contrast as a basis. Incorporation of slip agent definitively improves the mar resistance for both types of surfaces. Relationships between contrast, gloss and surface roughness in relation to mar visibility are discussed.     

Integration of Low-Impact Development into the International Stormwater BMP Database

Low impact development (LID) strategies are being encouraged in many communities as an approach to reduce potential adverse impacts of development on receiving streams. Many questions exist regarding how well various LID strategies perform in different settings, just as similar questions have been raised regarding performance of traditional stormwater best management practices (BMPs). Whereas historical focus on BMP performance has been water quality concentrations or loads, characterization of volume reduction benefits for both conventional and LID practices is increasingly an objective of researchers and stormwater managers. More than a decade ago, Urban Water Resources Research Council (UWRRC) members worked to develop a set of standardized monitoring and reporting protocols for traditional BMPs and to establish a master database for the purpose of evaluating BMP performance and the factors affecting performance. This effort culminated in the International Stormwater BMP Database (www.bmpdatabase.org), which contains data for more than 360 BMPs and continues to operate as a clearinghouse for stormwater BMP data and performance analyses. During 2008–2009, the International Stormwater BMP Database project expanded to better integrate LID into the database and develop a set of metrics that can be used to characterize BMP performance with regard to surface runoff volume reduction. This paper provides a condensed overview and progress report on the LID-focused effort, including the following topics: (1)?monitoring guidance for LID at the overall site development level, (2)?an overview of recent changes to the International Stormwater BMP Database to better accommodate LID studies, (3)?a summary of LID studies currently included in the database, and (4)?a proposed approach for evaluating performance of LID studies with regard to reducing surface runoff volumes.     

Transverse wakefield suppression using cell detuning assisted by manifold damping for high gradient linear colliders

Transverse wakefields excited by multiple bunches in ultra-relativistic charged particle beams in a linear collider must be adequately damped in order to preserve the luminosity of the colliding beams and to prevent a beam break up instability developing. Means of achieving this wakefield suppression are discussed in detail for high gradient normal conducting linacs. In particular the features of a damped and detuned series of structures (DDS) are described. Analytical expressions for the wakefield on short time scales are presented together with the circuit analysis required to rapidly analyse the general long-range behaviour in these linacs. A conspectus of experimental results along with theoretical predictions for this series of accelerating structures developed for the NLC/GLC is presented together with recent results on wakefield suppression for CLIC.     

Development of an automated testing system for vehicle infotainment system

A current premium vehicle is implemented with a variety of information, entertainment, and communication functions, which are generally referred as an infotainment system. During vehicle development, testing of the infotainment system at an overall level is conventionally carried out manually by an expert who can observe at a customer level. This approach has significant limitations with regard to test coverage and effectiveness due to the complexity of the system functions and human’s capability. Hence, it is highly demanded by car manufacturers for an automated infotainment testing system, which replicates a human expert encompassing relevant sensory modalities relating to control (i.e., touch) and observation (i.e., sight and sound) of the system under test. This paper describes the design, development, and evaluation of such a system that consists of simulation of vehicle network, vision-based inspection, automated navigation of features, random cranking waveform generation, sound detection, and test automation. The system developed is able to: stimulate a vehicle system across a wide variety of initialisation conditions, exercise each function, check for system responses, and record failure situations for post-testing analysis.