We have followed the growth of stature, sitting height, skinfolds, muscle widths measured radiologically, and skeletal maturity in growth hormone-deficient patients in whom hGH was given and withheld in alternating three-month periods throughout puberty (referred to as "off-hGH" and "on-hGH" periods). Six boys and four girls had true isolated GH deficiency and developed puberty spontaneously. Two boys had gonadotrophin deficiency plus GH deficiency, and five boys had multiple deficiencies; in these boys the signs of puberty were induced by hormone treatment. Boys with true isolated deficiency grew about two-thirds as much in height in the off-hGH periods as in the on-hGH periods; their total gain in height during the adolescent spurt would have been about 20 cm, instead of 30 cm, if hGH had been discontinued at the beginning of puberty. The effect of hGH was entirely on growth in leg-length, however, which virtually ceased during the off-hGH periods. Growth in sitting height altered little when hGH was withdrawn. Growth in limb muscles, however, was GH dependent throughout puberty; during the majority of periods when hGH was withheld, muscle was actually lost; this occurred in the boys who were receiving large doses of testosterone as well as in those producing their own normal amounts. Subcutaneous fat diminished when hGH was given and increased when it was withdrawn; this occurred independently of administration of testosterone. There was little evidence that growth of pubic and axillary hair progressed faster during on-hGH periods, except perhaps in patients with multiple deficiencies. There was some evidence, however, that bone age progressed less rapidly during on-hGH periods than during off-hGH periods in the patients with isolated deficiency. The results in the girls agreed with those in boys so far as stature was concerned, but the relationship with sitting height and leg length appeared to be different; the reasons for this are discussed. We conclude that all children with GH deficiency should continue on treatment with hGH throughout puberty, ideally until growth ceases. 相似文献
The on-chip inductive impact on signal integrity has been a problem for designs in deep-submicrometer technologies. The inductive impact increases the clock skew, max timing, and noise of bus signals. In this letter, circuit simulations using silicon-validated macromodels show that there is a significant inductive impact on the signal max timing (/spl sim/ 10% pushout versus RC delay) and noise (/spl sim/2/spl times/RC noise). In nanometer technologies, process variations have become a concern. Results show that device and interconnect process variations add /spl sim/ 3% to the RLC max-timing impact. However, their impact on the RLC signal noise is not appreciable. Finally, inductive impact in 65- and 45-nm technologies is investigated, which indicates that the inductance impact will not diminish as technology scales. 相似文献
Global predicate detection is a fundamental problem in distributed systems and finds applications in many domains such as testing and debugging distributed programs. This paper presents an efficient distributed algorithm to detect conjunctive-form global predicates in distributed systems. The algorithm detects the first consistent global state that satisfies the predicate even if the predicate is unstable. Unlike previously proposed run-time predicate detection algorithms, our algorithm does not require the exchange of control messages during the normal computation. All the necessary information to detect predicates is piggybacked on computation messages of application programs. The algorithm is distributed because the predicate detection efforts as well as the necessary information are equally distributed among the processes. We prove the correctness of the algorithm and compare its performance with respect to message, storage and computational complexities with that of the previously proposed run-time predicate detection algorithms 相似文献
This article explores that the study on bending of magneto-electric-elastic nanobeams relies on nonlocal elasticity theory. The Vlasov’s model foundation utilizes the silica aerogel foundation. The guiding expressions of nonlocal nanobeams in the considered framework are used extensively and where parabolic third-order beam theory is achieved after using Hamilton’s principle. Parametric work is introduced to scrutinize the influence of the magneto-electro-mechanical loadings, nonlocal parameter, and aspect ratio on the deflection characteristics of nanobeams. It is noticed that the boundary conditions, nonlocal parameter, and beam geometrical parameters have significant effects on dimensionless deflection of nanoscale beams.
The kinetics of colour (measured as Hunter ‘a’ value) degradation in tomato puree (Lycopersicon esculentum L.) has been studied over a temperature range of 50–120 °C (isothermal condition), and also during normal open pan cooking,
pressure cooking and cooking in a newly developed and patented fuel-efficient ‘EcoCooker’ (non-isothermal condition). The
degradation of colour as measured by Hunter ‘a’ value was found to follow first order kinetics. The temperature dependence of degradation was adequately modelled by Arrhenius
equation. A mathematical model has been developed using the isothermal parameters obtained to predict correctly the losses
of red colour from the time–temperature data of non-isothermal heating/processing method. The results obtained indicate a
colour degradation of similar magnitude in all the three modes of cooking used in the study. 相似文献
Hydrogels are being prepared for use in a wide variety of applications ranging from medicines, tissue engineering, superabsorbents, controlled release of drugs & fertilizers, and oil absorbers etc. This review highlights hydrogel structure and their different classifications under various heads. It also discusses various routes to obtain tailormade hydrogels by polymerizing a combination of two or more monomers with proper type of crosslinks in order to obtain desired properties in the resulting hydrogel. Novel hydrogel configurations like microgels and nanogels, slide ring gels, double network hydrogels and nanocomposite gels have also been reviewed. 相似文献
A 0.5(Ba0.7Ca0.3)TiO3–0.5Ba(Zr0.1Ti0.9)O3 (BCT-BZT) ceramic was studied for photocatalysis and piezocatalysis effects using dye degradation (methylene blue, rhodamine B, and methyl orange) and bacterial (Escherichia coli) disinfection from aqueous solution. To examine the effect of ferroelectric polarization, BCT-BZT powder was poled using the corona poling technique. Same time, BCT-BZT was converted into Ag/BCT-BZT composites as Ag induced surface plasmon resonance effect during photocatalysis. Piezocatalysis performance was assessed for dyes mineralization under ultrasonication. There was a significant impact of silver nanoparticles on the photo/piezocatalysis performance of BCT-BZT. Similarly, electric poling has also played a positive role in improving the photo/piezocatalysis in view of various dye degradation. These samples also showed effective antibacterial performance. 相似文献
Parasitoids are known to exploit volatile cues emitted by plants after herbivore attack to locate their hosts. Feeding and oviposition of a polyphagous herbivore can induce the emission of odor blends that differ among distant plant species, and parasitoids have evolved an incredible ability to discriminate them and locate their hosts relying on olfactive cues. We evaluated the host searching behavior of the egg parasitoid Cosmocomoidea annulicornis (Ogloblin) (Hymenoptera: Mymaridae) in response to odors emitted by two taxonomically distant host plants, citrus and Johnson grass, after infestation by the sharpshooter Tapajosa rubromarginata (Signoret) (Hemiptera: Cicadellidae), vector of Citrus Variegated Chlorosis. Olfactory response of female parasitoids toward plants with no herbivore damage and plants with feeding damage, oviposition damage, and parasitized eggs was tested in a Y-tube olfactometer. In addition, volatiles released by the two host plant species constitutively and under herbivore attack were characterized. Females of C. annulicornis were able to detect and significantly preferred plants with host eggs, irrespectively of plant species. However, wasps were unable to discriminate between plants with healthy eggs and those with eggs previously parasitized by conspecifics. Analysis of plant volatiles induced after sharpshooter attack showed only two common volatiles between the two plant species, indole and β-caryophyllene. Our results suggest that this parasitoid wasp uses common chemical cues released by many different plants after herbivory at long range and, once on the plant, other more specific chemical cues could trigger the final decision to oviposit.