Optimization of micromachined reflex klystrons for operation at terahertz frequencies

New micromachining techniques now provide us with the technology to fabricate reflex klystron oscillators with dimensions suitable for operation in the terahertz region of the electromagnetic spectrum. For the success of these devices, accurate designs are required since the optimization of certain parameters is critical to obtaining useful amounts of ac power. Classical models for device design have long been in existence, but these are no longer valid at terahertz frequencies. For this reason, we have developed a simulation tool, specifically aimed at the design of terahertz frequency reflex klystrons. The tool, based on the Monte Carlo algorithm, includes loss mechanisms and takes into account the main peculiarities expected for device operation at terahertz frequencies. In this study, the tool is used to study the influence of the electron beam aperture angle and cavity dimensions (particularly the grid spacing) on ac power generation. The results demonstrate that aperture angles of less than 10/spl deg/ are necessary for the optimization of output power. It is also found that the power output is highly sensitive to the distance between the grids.     

High quality gate dielectrics formed by rapid thermal chemical vapor deposition of silane and nitrous oxide

In the present study, we have performed electrical characterization of oxides deposited via rapid thermal chemical vapor deposition using SiH₄ and N₂O. We have investigated the effect of temperature, pressure, and SiH₄ to N₂O ratio on the electrical and material properties of as-deposited films. We have found that as-deposited oxides deposited at low temperatures, low pressures, and with a low silane to nitrous oxide ratio of ～0.5% give good material and electrical properties. The as-deposited films are stoichiometric in nature and have high deposition rates. As-deposited films had very low D_it values, high breakdown fields, and excellent subthreshold swing. The leakage currents and metal oxide semiconductor field effect transistor current drive, although lower than thermal oxides, were found to be quite acceptable. We have also investigated the thickness dependence of the films and found that as the film thickness is reduced below 50Å, the reliability improves for all oxides including the silicon-rich deposited oxides.     

Macrophage Immunomodulation Through New Polymers that Recapitulate Functional Effects of Itaconate as a Power House of Innate Immunity

Itaconate (ITA) is an emerging powerhouse of innate immunity with therapeutic potential that is limited in its ability to be administered in a soluble form. A library of polyester materials that incorporate ITA into polymer backbones resulting in materials with inherent immunoregulatory behavior is developed. Harnessing hydrolytic degradation release from polyester backbones, ITA polymers result in the mechanism specific immunoregulatory properties on macrophage polarization in vitro. In a functional assay, the polymer-released ITA inhibits bacterial growth on acetate. Translation to an in vivo model of biomaterial associated inflammation, intraperitoneal injection of ITA polymers demonstrate a rapid resolution of inflammation in comparison to a control polymer silicone, demonstrating the value of sustained biomimetic presentation of ITA.     

Progress towards using the speed of ultrasound for beef leanness classification

Following the observation of a high correlation between the reciprocal of the speed of ultrasound and lean proportion in beef carcasses, commercial equipment (VOSI) was developed and its performance alongside a smaller assembly (Mini G) is reported. The speed of ultrasound was measured through six sites on beef carcasses within 1 h of stunning: three sites with VOSI and three sites with Mini G. Sides were also scored for fatness and conformation using the EAAP system, and subcutaneous fat depth was measured at 25,50 and 75% of the width of M. longissimus thoracis from the midline at the last rib. All sides were dissected into subcutaneous fat, intermuscular fat, muscle and bone. The reciprocal speed averaged over the three VOSI sites (RV346) was the best single predictor of the proportion of lean in the side. Multiple regression analyses, in predicting per cent lean, showed that addition of conformation score improved the precision of fat score and fat depth for a group of 26 sides. It did not provide a significant improvement over RV346. However, in another group of 50 sides showing more variation in side mass and conformation, conformation score did significantly improve RV346. The best prediction of per cent lean, involving RV346 and tissue thicknesses, gave a residual standard deviation of 1·35%, and conformation score did not significantly improve this regression.     

The prognosis of the transitory disturbances of av-conduction following cardiac surgery (author's transl)

Out of 2250 cases with open heart surgery 106 patients were examined because of disturbances of av-conduction in the Department for Cardiology of the Childrens Hospital of the University of G?ttingen. 38, 7 percent of all av-conduction disturbances have persisted, whereas 61, 3 percent were reversible. Especially the ventricular septal defects, the tetralogy of Fallot and the endocardial cushion defects are discussed. These lesions are predisposed for postsurgical av-disturbances because they are near to the av-conduction tissue. In this paper it has been demonstrated that the av-conduction disturbances, which last for more than one week, have only a little chance to return to sinus rhythm. Those which endure more than four weeks, will persist. The longer the av-conduction disturbances are lasting, the less is the possibility for restitution of sinus rhythm.     

High rates of [1-14C]acetate incorporation into the lipid of isolated spinach chloroplasts

Spinach chloroplasts, isolated by techniques yielding preparations with high O2- evolving activity, showed rates of light-dependent acetate incorporation into lipids 3-4 fold higher than any previously reported. Incorporation rates as high as 500 nmol of acetate/h per mg of chlorophyll were measured in buffered sorbitol solutions containing only NaHCO3 and [1-14C]acetate, and as high as 800 nmol/h per mg of chlorophyll when 0.13 mM-Triton X-100 was also included in the reaction media. The fatty acids synthesized were predominantly oleic (70-80% of the total fatty acid radioactivity) and palmitic (20-25%) with only minor amounts (1-5%) of linoleic acid. Linolenic acid synthesis was not detected in the system in vitro. Free fatty acids accounted for 70-90% of the radioactivity incorporated and the remainder was shared fairly evenly between 1,2-diacylglycerols and polar lipids. Oleic acid constituted 80-90% of the free fatty acids synthesized, but the diacylglycerols and polar lipids contained slightly more palmitic acid than oleic acid. Triton X-100 stimulated the synthesis of diacylglycerols 3-6 fold, but stimulated free fatty acid synthesis only 1-1.5-fold. Added glycerol 1-phosphate stimulated both the synthesis of diacylglycerols and palmitic acid relative to oleic acid, but did not increase acetate incorporation into total chloroplast lipids. CoA and ATP, when added separately, stimulated acetate incorporation into chloroplast lipids to variable extents and had no effect on the types of lipid synthesized, but when added together resulted in 34% of the incorporated acetate appearing in long-chain acyl-CoA. Pyruvate was a much less effective precursor of chloroplast fatty acids than was acetate.     

Significance of a new type of human fetal hemoglobin carrying a replacement isoleucine replaced by threonine at position 75 )E 19) of the gamma chain

Mating speed of flies which have been aged either in the light, in the dark or in a light-and-dark cycle was measured using two strains, Rochester (R) and Salvador (S), of Drosophila mercatorum. A significant difference in mating tendency depending on the condition of pretreatment was found between R and S strains, while both strains showed a similar pattern of the diurnal rhythm in the light-and-dark cycle. Compared under the same conditions, S flies usually showed a higher mating speed than R flies. Mating speed seems to be affected by at least two different genetic systems. One of them is the genetic system determining absolute speed of mating. Another is the genetic system determining sensitivity to the environmental conditions. There may be considerable differentiation in both systems between R and S strains.     

Azo-and nitro-reductase activities and cytochromes of Axcaris lumbricoides var suum and Moniezia expansa

1. Isoelectric focusing failed to separate the azo- and nitro-reductases in enzyme preparations from either the nematode Ascaris lumbricoides var suum or the cestode Moniezia expansa. The isoelectric point of the reductases from A. lumbricoides var suum was 4-75, and that of the reductases from M. expansa, 4-50. 2. Cytochromes P-450 and b5 were not detected in the 100 000 g pellet of tissue homogenates from either A. lumbricoides var suum of M. expansa. These cytochromes were not induced in either helminth by 20-methylcholanthrene or 1,2-benzanthracene. 3. The absence of cytochromes P-450 and b5 from A. lumbricoides var suum and M. expansa may be the reason for their inability to metabolize drugs by oxidative pathways and for the 100 000 g pellets of their tissue homogenates being unable to reduce azo- or nitro-compounds.