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21.
V Douzdjian SS Bhaskar PK Baliga KK Gugliuzza PR Rajagopalan 《Canadian Metallurgical Quarterly》1997,20(8):1310-1314
OBJECTIVE: The racial impact on graft outcome is not well defined in diabetic recipients. The purpose of this study is to analyze our experience with kidney-alone (A) and kidney-pancreas (KP) transplantation in type 1 diabetic recipients and evaluate the impact of racial disparity on outcome. RESEARCH DESIGN AND METHODS: The records of 217 kidney transplants (118 KA, 99 KP) performed on type 1 diabetic patients between 1985 and 1995 at the Medical University of South Carolina and the University of Texas Medical Branch were reviewed. RESULTS: A total of 53 (31%) white patients and 15 (33%) black patients experienced at least one episode of biopsy-proven acute rejection of the renal graft (NS). Patient survival at 1, 2, and 5 years was similar in white (92, 87, 69%) and black (91, 91, 69%) patients (NS). Kidney graft survival at 1, 2, and 5 years in the KA group was 72, 62, and 42% in blacks, compared with 79, 76, and 53% in whites (NS). Kidney graft survival at 1, 2, and 5 years in the KP group was 92, 92, and 74% in blacks, compared with 83, 77, and 58% in whites (NS). Pancreas graft survival at 1, 2, and 5 years was 81, 81, and 81% in blacks, compared with 81, 75, and 62% in whites (NS). Cox regression analysis revealed that donor age > or = 40 years increased the risk of renal graft failure 6.2-fold (P = 0.0001), whereas the addition of a pancreas transplant to a kidney and a living-related transplant decreased the risk of failure of the kidney graft 0.2 (P = 0.005) and 0.1 times (P = 0.005). CONCLUSIONS: Our results suggest that when compared with whites, there may be a trend toward an improved kidney and pancreas graft outcome in blacks undergoing KP transplants. These findings suggest that diabetes may override the risk factors that account for the pronounced disparity in outcome observed between nondiabetic white and black recipients. 相似文献
22.
Ionic conductivity in poly(vinyl butyral) based polymeric electrolytes: Effect of solvents and salts
Li+ conductive solid polymeric electrolytes (SPEs) have been prepared by complexing Li salts LiX (X = I, SCN, CLO4, CF3SO3) with poly(vinyl butyral) (PVB) an amorphous polymer with a low Tg value and well known for its outstanding laminating properties. These self-supporting SPEs have been prepared by the solution cast technique using cyclohexanone, tetrahydrofuran, and n-butyl alcohol as solvents. The XRD and DSC investigations correlated to measured ionic conductivities have revealed that in addition to the amorphous nature of the resulting complex, its Tg value, the concentration and the values of the lattice energies of the complexing salts, the solvent used in making the SPEs also govern the value of ionic conductivity. Highest ionic conductivity values attained in SPEs made with n-butyl alcohol are explained in terms of the interception of the hydrogen bonding due to solvation. 相似文献
23.
E Prescott M Osler PK Andersen A Bjerg HO Hein K Borch-Johnsen P Lange P Schnohr J Vestbo 《Canadian Metallurgical Quarterly》1997,26(6):1214-1218
BACKGROUND: Two recent much cited publications have raised the concern that risk associated with cigarette smoking has so far been underestimated. In this study we wish to determine whether excess all-cause mortality associated with smoking has increased during the last 20-30 years in a study population representative of the general Danish population and whether any such changes relate to changes in smoking behaviour. METHODS: Pooled data from three prospective population studies conducted in Copenhagen with detailed information on smoking habits. A total of 31,194 subjects, 17,669 males and 13,525 females, initially examined between 1964 and 1992 with examinations repeated at intervals from 1-10 years, were followed until 1995 for all-cause mortality. Relative mortality risk in smokers versus never-smokers was calculated within periods of five calendar years and compared throughout the study period. RESULTS: Male smokers' exposure did not change during the study period whereas female smokers' exposure to tobacco increased in terms of age at smoking onset, quantity smoked and depth of inhalation. During follow-up 5744 males and 2900 females died. In males, death rate ratios (comparing continuous smokers with never-smokers) did not change in the study period. In females, ratios increased from 1964-1978 to 1979-1994 by a factor of 1.3 (95% confidence interval 1.0-1.8). CONCLUSIONS: In agreement with the observed changes in smoking habits, excess mortality in male smokers did not increase whereas excess mortality in female smokers increased slightly. 相似文献
24.
Quantitation of Cefaclor in Pharmaceutical Dosage Forms Using High Performance Liquid Chromatography
Mary Mathew V. Das Gupta Charlie Bethea 《Drug development and industrial pharmacy》1993,19(14):1723-1729
A stability-indicating high-performance liquid chromatography for the quantitation of cefaclor in pharmaceutical dosage forms has been developed. The method is accurate and precise with a percent relative standard deviation of 1.2 based on 5 readings. A number of inactive ingredients present in the capsules and suspensions did not interfere with the assay procedure. The extraction procedure from the dosage forms is very simple. The recovery from the synthetic mixtures was quantitative. The capsules which had expired 3 years ago lost only 3% of the potency. The drug appears to be very sensitive to strong acids or bases since a 5 minute boiling caused 100% degradation of drug in both the solutions. 相似文献
25.
Mechanical properties of polypropylene-g-poly(methacrylic acid) fibers, prepared by graft copolymerization of methacrylic acid onto polypropylene fiber using simultaneous gamma ray irradiation technique, were evaluated. In general, an improvement in the mechanical behavior of the polypropylene fiber by grafting was observed. Denier and initial modulus of the fiber showed a linear increase with the percent graft, and elongation showed an opposite trend. The results have been explained in terms of reinforcing effect of poly(methacrylic acid) grafts and reduction in the segmental mobility of the polymeric chains. Tenacity also increases up to certain graft level, beyond which a sharp decrease occurs, probably due to the influence on the compactness of the macromolecular chains with the further grafting. 相似文献
26.
27.
M. K. Karthikeyan R. K. Gupta V. Rajesh B. R. Ghosh P. P. Sinha 《Journal of Failure Analysis and Prevention》2007,7(6):429-433
17-4 PH stainless steel is used as internal drive shaft material in liquid engine pumps. One of the drive shafts failed during
operation. The shaft pieces were in contact for short duration after failure, which has resulted in abrasion of fractured
surfaces. Samples from the location of failure were taken, and investigation of the failure was carried out using optical
and scanning electron microscopy. The microstructural analysis of the material and fractographic analysis of the fractured
surface show that the failure was caused by excessive torsion. 相似文献
28.
Gupta R. Hero A.O. III 《IEEE transactions on information theory / Professional Technical Group on Information Theory》2003,49(8):1951-1969
We investigate high-rate quantization for various detection and reconstruction loss criteria. A new distortion measure is introduced which accounts for global loss in best attainable binary hypothesis testing performance. The distortion criterion is related to the area under the receiver-operating-characteristic (ROC) curve. Specifically, motivated by Sanov's theorem, we define a performance curve as the trajectory of the pair of optimal asymptotic Type I and Type II error rates of the most powerful Neyman-Pearson test of the hypotheses. The distortion measure is then defined as the difference between the area-under-the-curve (AUC) of the optimal pre-encoded hypothesis test and the AUC of the optimal post-encoded hypothesis test. As compared to many previously introduced distortion measures for decision making, this distortion measure has the advantage of being independent of any detection thresholds or priors on the hypotheses, which are generally difficult to specify in the code design process. A high-resolution Zador-Gersho type of analysis is applied to characterize the point density and the inertial profile associated with the optimal high-rate vector quantizer. The analysis applies to a restricted class of high-rate quantizers that have bounded cells with vanishing volumes. The optimal point density is used to specify a Lloyd-type algorithm which allocates its finest resolution to regions where the gradient of the pre-encoded likelihood ratio has greatest magnitude. 相似文献
29.
A tutorial review of a classic paper by Samuel J. Mason (1954) is described. That paper contained the first definition of a unilateral power gain for a linear two-port and the first proof that this grain is invariant with respect to linear lossless reciprocal four-port embeddings, thereby making it useful as a figure of merit intrinsic to the device. In this work, that original paper is brought up to date, a tutorial exposition of its contents is presented in a modern form, and its significance and applications in microwave engineering are discussed. The subsequent advances in the subject area are summarized, so that the original paper can be placed within a broader context and understood with a more general perspective 相似文献
30.
E Spranzi JY Djeu SL Hoffman PK Epling-Burnette DK Blanchard 《Canadian Metallurgical Quarterly》1993,82(5):1578-1585
The present study shows that extracellular adenosine triphosphate (ATP) has the capacity to mediate dose-dependent lysis of the monocytic leukemia cell line THP-1. The lysis, assessed by 51Cr release, was found to be selective for ATP, because adenosine diphosphate (ADP) or other nucleotides were less effective in their ability to lyse the cells. The amount of 51Cr released was particularly enhanced by the stimulation of the cells with 1,000 U/mL of interferon gamma (IFN-gamma) for 3 days, and the sensitivity was time and dose dependent. Analysis of the mechanism of lysis indicated that the fully ionized form, ATP4-, mediated the lysis, because the addition of cation chelators or the absence of the divalent cations, Ca2+ and Mg2+, in the culture medium of a 6-hour 51Cr release assay increased the percent specific lysis. Therefore, the ATP receptors on THP-1 cells were classified as P2Z purinoceptors. Moreover, it is shown here that the Ca2+/calmodulin complex plays a role in the regulation of the lysis by extracellular ATP of THP-1 cells, because antagonists of this complex, such as trifluoperazine or KN-62, were found to inhibit the ATP-mediated cell lysis. 相似文献