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71.
72.
W. Jill Harrison K. R. Pearson Alan A. Powell E. John Small 《Computational Economics》1994,7(3):203-223
General equilibrium moels are usually represented as a system of levels equations (e.g., in North America) or a system of linearized equations (e.g., in Australia). Either representation can be used to obtain accurate solutions. General-purpose software is available in both cases-GAMS or MPS/GE is typically used by levels modellers and GEMPACK by linearizers. Some equations (notably accounting identities) are naturally expressed in the levels while others (especially behavioural equations) are naturally expressed in a linearized form. This paper describes the new GEMPACK facility for solving models represented as a mixture of levels and linearized equations and discusses the advantages to modellers of using such a representation. 相似文献
73.
PG McNally NT Raymond ML Burden PR Burton JL Botha PG Swift AC Burden JR Hearnshaw 《Canadian Metallurgical Quarterly》1995,12(11):961-966
The relative risk of death by calendar date of diagnosis was investigated in a population-based incident cohort of 845 (463 males:382 females) IDDM diagnosed in Leicestershire before the age of 17 years between 1940 and 1989. The mortality status of 844 (99.9%) patients was determined as of the 31 December 1991, representing 14,346 person-years of risk. Trends in relative risk of death were investigated using Cox proportional hazards modelling for within cohort comparisons and age/sex and calendar time adjusted standardized mortality ratios (SMR) using generalized linear modelling for external comparisons. Median age at diagnosis was 10 years (range 3 months to 16 years); median duration of diabetes 15 years (range 1-51 years). Forty-four patients had died (5.2%; median age at death 31 years, range 11-51 years). A further four patients died at presentation (within 24 h) from ketoacidosis and are excluded from all analyses. Calendar date of diagnosis was found to be an important predictor of mortality. Adjusting for attained age there was evidence of a decline in relative risk of death with calendar date of diagnosis of 3.4% (95% CI, 0.005-6.9%) per annum, equivalent to a 32% fall per decade (95% CI, 5-51%), or 84% (95% CI, 21-97) from 1940 to 1989. The data are consistent with a large fall in mortality between the 1940s and 1950s representing over 50% of the total reduction in mortality between 1940 and 1991. Neither sex nor age at diagnosis were significant predictors of mortality. Over the study period 1940-89 the SMR (male and female combined) fell from 981 (541-1556) to 238 (60-953) relative to the general population. This population-based study shows that the prognosis for Type 1 (insulin-dependent) diabetes mellitus has improved markedly over the period 1940-1991. 相似文献
74.
Williams Ludwell Harrison III 《LISP and Symbolic Computation》1989,2(3-4):179-396
Lisp and its descendants are among the most important and widely used of programming languages. At the same time, parallelism in the architecture of computer systems is becoming commonplace. There is a pressing need to extend the technology of automatic parallelization that has become available to Fortran programmers of parallel machines, to the realm of Lisp programs and symbolic computing. In this paper we present a comprehensive approach to the compilation of Scheme programs for shared-memory multiprocessors. Our strategy has two principal components:interprocedural analysis andprogram restructuring. We introduceprocedure strings andstack configurations as a framework in which to reason about interprocedural side-effects and object lifetimes, and develop a system of interprocedural analysis, using abstract interpretation, that is used in the dependence analysis and memory management of Scheme programs. We introduce the transformations ofexit-loop translation andrecursion splitting to treat the control structures of iteration and recursion that arise commonly in Scheme programs. We propose an alternative representation for s-expressions that facilitates the parallel creation and access of lists. We have implemented these ideas in a parallelizing Scheme compiler and run-time system, and we complement the theory of our work with snapshots of programs during the restructuring process, and some preliminary performance results of the execution of object codes produced by the compiler.This work was supported in part by the National Science Foundation under Grant No. NSF MIP-8410110, the U.S. Department of Energy under Grant No. DE-FG02-85ER25001, the Office of Naval Research under Grant No. ONR N00014-88-K-0686, the U.S. Air Force Office of Scientific Research under Grant No. AFOSR-F49620-86-C-0136, and by a donation from the IBM Corportation. 相似文献
75.
76.
Nicholas P. Petropolis Harrison M. Petropolis Nicole E. MacNeil Taylor M. Doucet D. Gerrard Marangoni 《Journal of surfactants and detergents》2021,24(1):51-66
The critical micelle concentrations (CMC) values and counterion dissociation (α values) have been determined for a number of mixed micellar systems consisting of two typical ionic surfactants and glycol ethers (glymes) as cosurfactants, namely diethylene glycol dimethyl ether, diethylene glycol diethyl ether, triethylene glycol dimethyl ether, and tetraethylene glycol dimethyl ether. Conductance experiments were used to determine the CMC and α values of the mixed micelles as a function of glyme concentration in the aqueous mixed solvent. Favorable interactions between sodium dodecyl sulfate micelles and glyme cosurfactants were deduced from the decreases in the CMC values and the large increase in the α values of these systems as a function of increasing glyme concentration in the mixed solvents. In contrast to the anionic surfactant/glyme systems, in general, there appeared to be little favorable interactions between the surfactant and glymes when micelles of the cationic surfactant dodecyltrimethylammonium bromide were formed in water/glyme solvent systems containing an increasing amount of the glymes. The interaction of glymes with the surfactant micelles was examined closely via 13C nuclear magnetic resonance (NMR) chemical shifts for both surfactant and glyme carbons; these chemical shifts changes were interpreted in terms of the distribution and the localization of the glymes in the aggregates. Finally, partition constants, determined from two-dimensional diffusion-oriented spectroscopy (2D-DOSY) experiments, were used to calculate thermodynamic quantities of transfer of the glymes between the bulk phase and the self-assembled aggregates. All these results are interpreted in terms of the key contributions that both the glyme ethoxylated groups and alkyl endgroups make to the hydrophobic interactions. 相似文献
77.
Railway Engineering Science - Electrified railways are becoming a popular transport medium and these consume a large amount of electrical energy. Environmental concerns demand reduction in energy... 相似文献
78.
Dale A. Creaser Philip G. Harrison M. A. Morris B. A. Wolfindale 《Catalysis Letters》1994,23(1-2):13-24
X-ray photoelectron spectroscopy has been used to examine the nature of the oxide overlayers on a passivated cerium metal foil as a function of a variety of oxidation and reduction treatments. Oxidation of a clean uncontaminated cerium(III) oxide surface is facile at room temperature and produces non-stoichiometric ceria (CeO2–x) at oxygen doses as low as 10 L. At higher doses the overlayer thickens, and after a dose of 160 L the layer depth exceeds the Ce 3d photoelectron attenuation distance of about 20 Å. High pressure treatment of the foil in oxygen (0.5 bar at RT and 473 K) produces CeO2 in a high degree of crystallographic order such that O 1s photoelectron intensities are increased above that expected from a randomly oriented powder. An attempt to reduce the CeO2 layer formed by controlled oxidation with CO (633 K, 14 h, 0.6 bar) results in the formation of a carbonated surface layer. Results following attempts to reoxidise this layer are discussed. 相似文献
79.
Crystal structure of TNF-alpha mutant R31D with greater affinity for receptor R1 compared with R2 总被引:2,自引:0,他引:2
Reed C; Fu ZQ; Wu J; Xue YN; Harrison RW; Chen MJ; Weber IT 《Protein engineering, design & selection : PEDS》1997,10(10):1101-1107
Crystal structures have been determined of recombinant human tumor necrosis
factor-alpha (TNF-alpha) and its R31D mutant that preferentially binds to
TNF receptor R1 with more than seven times the relative affinity of binding
to receptor R2. Crystals of the wild-type TNF were of space group
P4(1)2(1)2 and had unit cell dimensions of a = b = 94.7 and c = 117.4 A.
Refinement of the structure gave an R-factor of 22.3% at 2.5 A resolution.
The crystals of TNF R31D mutant diffracted to 2.3 A resolution, and were of
identical space group to the wild type with unit cell dimensions of a = b =
95.4 and c = 116.2 A, and the structure was refined to an R-factor of
21.8%. The trimer structures of the wild-type and mutant TNF were similar
with a root mean square (r.m.s.) deviation of 0.56 A for Calpha atoms;
however, the subunits within each trimer were more variable with an average
r.m.s. deviation of 1.00 A on Calpha atoms for pairwise comparison of
subunits. Model complexes of TNF with receptors R1 and R2 have been used to
predict TNF-receptor interactions. Arg31 in all three subunits of wild-type
TNF is predicted to form an ionic interaction with the equivalent glutamic
acid in both receptors R1 and R2. Asp31 of the TNF R31D mutant is predicted
to interact differently with the two receptors. The side chain of Asp31 in
two subunits of the TNF mutant is predicted to form hydrogen bond
interactions with Ser59 or Cys70 of R1, while it has no predicted
interactions with R2. The loss of three strong ionic interactions of Arg31
and the electrostatic repulsion of Asp31 with Glu in the receptors is
consistent with the reduced binding of the R31D mutant to both receptors
relative to wild-type TNF. The replacement of these ionic interactions by
two weaker hydrogen bond interactions between Asp31 of the R31D mutant and
R1, compared with no interactions with R2, is in agreement with the
observed preferential binding of the R31D mutant to R1 over R2. Analysis of
the structure and function of receptor-discriminating mutants of TNF will
help understand the biological role of TNF and facilitate its use as an
antitumor agent.
相似文献
80.
Non-Markovian diffusion transport in polymers was studied. Applying the results of various researchers, a stretched exponential relaxation function was obtained and a linear viscoelastic constitutive equation formulated. Frequency dependent material functions, obtained from this constitutive equation were studied and the results successfully compared with experimental data for polyethylene oxide solutions. Sorption kinetics in a polymeric film were also studied. © 1994 John Wiley & Sons, Inc. 相似文献