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61.
Ependymomas are rare neuroectodermal tumors arising from ependymal cells of the ventricular system, choroid plexus, filum terminale, and central canal of the spinal cord (1,2). This review focuses on intracranial ependymomas with special emphasis on pathology, etiology, cytogenetic characteristics, and adjuvant radiation therapy. Recent advances in neurosurgical technique, radiation therapy, and molecular biology have affected management of these tumors and have the potential to increase long-term cure rates. The role of highly advanced radiation therapy techniques such as stereotactic radiosurgery will need to be better defined. 相似文献
62.
CR Divgi AM Scott K McDermott PS Fallone S Hilton K Siler N Carmichael F Daghighian RD Finn AM Cohen 《Canadian Metallurgical Quarterly》1994,21(1):9-15
Ten patients with colorectal cancer metastases received 125I-B72.3 and 131I-CC49 prior to laparotomy (five patients received 1 mg, and five 20 mg of each mAb). Tumor:serum ratios of 131I-CC49 were better than those of 125I-B72.3 (P < 0.01 at 1 mg; P = 0.05 at 20 mg; P < 0.01 at both doses). All known lesions > or = 1 cm in diameter were visualized at the 20 mg dose. There was no difference in absolute tumor uptake of 125I-B72.3 or 131I-CC49. We conclude that mAb CC49 has better relative uptake in colorectal cancers than mAb B72.3. 相似文献
63.
TR O''Brien WA Blattner D Waters E Eyster MW Hilgartner AR Cohen N Luban A Hatzakis LM Aledort PS Rosenberg WJ Miley BL Kroner JJ Goedert 《Canadian Metallurgical Quarterly》1996,276(2):105-110
Normal women produce small amounts of active androgens. When androgen levels are elevated, such as for example in the polycystic ovary syndrome, this is followed by the development of male physical characteristics and muscle mass, structure and function as well as android adipose tissue distribution and function. Psychological features and stress reactions also seem similar to those of men. Such women have an increased risk of developing hypertension, non-insulin-dependent diabetes mellitus and cardiovascular disease. Recent data have shown that these physical, and psychological characteristics, as well as risk of ill health, are also found in the population of women selected at random. Women in the lowest quintiles of levels of sex-hormone-binding globulin--an indicator inversely related to active androgens--are at risk of developing hypertension, non-insulin-dependent diabetes mellitus and cardiovascular mortality. The mechanism probably includes muscular insulin resistance, following a relative androgen excess. It is thus apparent that androgens, even within the highest levels of the nonselected population of women, are powerful predictors of serious disease development. The population at risk might be as large as about 20% of middle-aged women. This is an area of female disease risk which requires more attention in screening and intervention procedures. 相似文献
64.
We report a case of aorto-enteric and aorto-colonic fistulae in a 73 year old man with no previous abdominal surgery which resulted in massive gastrointestinal haemorrhage and death and was undiagnosed despite several hospital admissions and endoscopic examinations. This case serves to highlight an extremely rare but fatal condition, which is potentially treatable, if an early diagnosis is made. 相似文献
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A case of serious, recurrent enterorrhagia is reported. The cause could not be identified with normal diagnostic tools and was discovered only after explorative laparotomy. The finding was benign ulcerated tumour of the small intestine, histologically defined as fibroma with fluorishing cellularity. 相似文献
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New-born pig proximal colon, incubated in vitro, transports methionine with a Km of 0-33 mM and a Vmax of 0-62 mumole cm-2h-1. There is still a net transport of methionine on day 4, but the Km now increases to 10 mM and the Vmax falls to 0-15 mumole cm-2h-1. There is no net transport of methionine across proximal colons taken from 10-day-old pigs. 2. The mean intramucosal concentration of methionine, following incubation in medium containing 1 mM methionine, is 7-18+/-0-8 mM for the new-born, 0-55+/-0-05 mM for the 4-day-old and 0-31+/-0-06 mM for the 10-day-old pig. 3. Both methionine and glucose cause an immediate increase in the short-circuit current of new-born and 1-day-old pig colons. The kinetics for this interaction with methionine gives a Km for methionine of 0-24 mM and a maximum effect of 27 muA cm-2. This effect is not seen in 4- or 10-day-old pigs. 4. Net Na+ transport across the new-born pig proximal colon, measured in the absence of methionine, is about three times that calculated from the measured short-circuit current. Methionine increases the mucosal to serosal flux of Na+ by an amount roughly equal to that predicted from the increase in short-circuit current. The ability of glucose and methionine to affect short-circuit current is lost by day 4. 5. Short-circuit current, measured in the absence of methionine or glucose, increases between day 1 and 2 of post-natal life. This increased electrogenicity is maintained for up to at least 10 days after birth. 6. The pig proximal colon has many of the properties of a small intestine at birth. It actively transports methionine and the presence of methionine stimulates the absorption of Na+. These effects could be physiologically important in the pig, where the normal absorptive function of the intestine is temporarily inhibited at birth by the intestinal transmission of immune globulins. 相似文献
70.
MA Downham R Scott DG Sims JK Webb PS Gardner 《Canadian Metallurgical Quarterly》1976,2(6030):274-276
Eight out of 115 infants admitted to hospital with respiratory syncytial (RS) virus infection had been breast-fed compared with 46 out of 167 controls; this difference was statistically significant. Twenty-one specimens of human colostrum were examined, and all contained RS virus neutralising activity. Specific IgA and IgG were detected in 18 specimens, whereas IgM was detected in none. The titre of IgA antibody was usually higher and correlated more closely to the titre of neutralising activity than that of IgG. Infants inhale milk feeds and regurgitate them through the nose, and the IgA collecting in the respiratory tract might protect against severe respiratory infection. Alternatively, if severe RS virus illness is a sign of hypersensitivity to the virus breast-feeding might protect the infant from an early sensitising infection. 相似文献