Chemotherapy in non-small cell lung cancer: a review

Lung cancer, of which non-small cell carcinoma is the most common, has been a significant therapeutic challenge for decades and will remain so for decades to come. Despite its prevalence, progress in the management of non-small cell lung cancer has been relatively slow. This is in part due to the pessimism of most physicians treating this disease, which has resulted in a relatively lackadaisical attitude with regards to clinical trials when compared to other solid tumours like breast or colorectal cancers. Nevertheless, the past decade has seen significant progress, specifically with regards to the management of locally advanced disease. Chemotherapy, though shown to be biologically active in non-small cell lung cancer, is considered an ineffective palliative tool in the setting of metastatic disease due to its toxicities and the "less than encouraging" response rates generated by the cisplatin-based combination regimen which is generally considered to be the most active currently available. The advent of new active agents such as paclitaxel and vinorelbine which are potentially less toxic may change this view. Conversely, the response rate of locally advanced disease to chemotherapy is significantly higher and this has resulted in numerous multimodality trials of neoadjuvant chemotherapy prior to surgery and/or radiation. To date, a number of randomised trials have shown that this approach can result in significant survival benefit for patients with locally advanced disease. An alternative approach makes use of the potential synergism between certain chemotherapeutic agents (such as cisplatin) and radiation when used concurrently. However, data on concurrent chemoradiotherapy in locally advanced disease have been largely based on single-arm studies and are inconclusive. Three randomised trials on concurrent chemoradiotherapy have been shown benefit for the use of combined modality in locally advanced disease. Hence, treatment of locally advanced disease should include chemotherapy as part of the combined modality approach. However, the optimal sequencing of these modalities would require well-designed randomised trials to determine.     

Neural network based controller for Cr–Fe batch reduction process

An automated pilot plant has been designed and commissioned to carry out online/real-time data acquisition and control for the Cr⁶⁺–Fe²⁺ reduction process. Simulated data from the Cr⁶⁺–Fe²⁺ model derived are validated with online data and laboratory analysis using ICP-AES analysis method. The distinctive trend or patterns exhibited in the ORP profiles for the non-equilibrium model derived have been utilized to train neural network-based controllers for the process. The implementation of this process control is to ensure sufficient Fe²⁺ solution is dosed into the wastewater sample in order to reduce all Cr⁶⁺–Cr³⁺. The neural network controller has been utilized to compare the capability of set-point tracking with a PID controller in this process. For this process neural network-based controller dosed in less Fe²⁺ solution compared to the PID controller which hence reduces wastage of chemicals. Industrial Cr⁶⁺ wastewater samples obtained from an electro-plating factory has also been tested on the pilot plant using the neural network-based controller to determine its effectiveness to control the reduction process for a real plant. The results indicate the proposed controller is capable of fully reducing the Cr⁶⁺–Cr³⁺ in the batch treatment process with minimal dosage of Fe²⁺.     

Business processes in the agile organisation: a socio-technical perspective

This paper takes a cross-disciplinary view of the ontology of “business process”: how the concept is treated in the IS research literature and how related concepts (with stronger human behavioural orientation) from organisation and management sciences can potentially inform this IS perspective. In particular, is there room for socio-technical concepts such as technology affordance, derived from the constructivist tradition, in improving our understanding of operational business processes, particularly human-centric business processes? The paper presents a theoretical framework for understanding the role of business processes in organisational agility that distinguishes between the process-as-designed and the process-as-practiced. How this practice aspect of business processes also leads to the improvisation of various information technology enablers, is explored using a socio-technical lens. The posited theoretical framework is illustrated and validated with data drawn from an interpretive empirical case study of a large IT services company. The research suggests that processes within the organisation evolve both by top-down design and by the bottom-up routinisation of practice and that the tension between these is driven by the need for flexibility.     

Stability of neutral stochastic switched time delay systems: An average dwell time approach

This paper considers a class of stochastic systems referred to as stochastic switched systems of neutral type with time‐varying delay, which combines switched systems with neutral stochastic systems. The systems consist of subsystems of two forms: (i) only stable subsystems and (ii) both stable subsystems and unstable subsystems. By establishing an integral inequality, the exponential stability in pth(p≥1)‐moment for such systems with only stable subsystems is first considered. Then, by using an average dwell time approach, the exponential stability in pth(p≥1)‐moment for the second form is addressed. An important finding of this study is that when the average dwell time is chosen to be sufficiently large and the total activation time of unstable subsystems is relatively small compared with that of stable subsystems, the exponential stability in pth(p≥1)‐moment for such systems can be guaranteed. Two major advantages of these new results are that the differentiability or continuity of the delay function is not required compared with the existing results in the literature, and the proposed approaches can be used to consider the case when the neutral item and the stochastic perturbation are simultaneously presented. An example is provided to verify the effectiveness and potential of the theoretic results obtained. Copyright © 2016 John Wiley & Sons, Ltd.     

Restoring warped document images through 3D shape modeling

Scanning a document page from a thick bound volume often results in two kinds of distortions in the scanned image, i.e., shade along the "spine" of the book and warping in the shade area. In this paper, we propose an efficient restoration method based on the discovery of the 3D shape of a book surface from the shading information in a scanned document image. From a technical point of view, this shape from shading (SFS) problem in real-world environments is characterized by 1) a proximal and moving light source, 2) Lambertian reflection, 3) nonuniform albedo distribution, and 4) document skew. Taking all these factors into account, we first build practical models (consisting of a 3D geometric model and a 3D optical model) for the practical scanning conditions to reconstruct the 3D shape of the book surface. We next restore the scanned document image using this shape based on deshading and dewarping models. Finally, we evaluate the restoration results by comparing our estimated surface shape with the real shape as well as the OCR performance on original and restored document images. The results show that the geometric and photometric distortions are mostly removed and the OCR results are improved markedly.     

Evidence for transient composition variations at GaAs/Ga1−xAlxAs heterostructure interfaces prepared by metal-organic chemical vapour deposition

The composition profiles of GaAs/Ga_1?xAl_xAs heterostructures prepared in two different Metal-Organic Chemical Vapour Deposition (MOCVD) reactors have been studied. Transmission electron microscopy (TEM). and Auger and secondary ion mass spectrometry (SIMS) sputter profiling results are in good agreement and interface widths below 20 å have been achieved. Significant new results on transient phenomena have been obtained. showing that large and sometimes very sharp excursions in composition can be associated with valve switching actions. Direct evidence is presented that gas pressure or flow transients can occur during valve operations. and it is suggested that such instabilities are the cause of the effects observed.     

An optimization model for storage yard management in transshipment hubs

This paper studies a yard storage allocation problem in a transshipment hub where there is a great number of loading and unloading activities. The primary challenge is to efficiently shift containers between the vessels and the storage area so that reshuffling and traffic congestion is minimized. In particular, to reduce reshuffling, a consignment strategy is used. This strategy groups unloaded containers according to their destination vessel. To reduce traffic congestion, a new workload balancing protocol is proposed. A mixed integer-programming model is then formulated to determine the minimum number of yard cranes to deploy and the location where unloaded containers should be stored. The model is solved using CPLEX. Due to the size and complexity of this model two heuristics are also developed. The first is a sequential method while the second is a column generation method. A bound is developed that allows the quality of the solution to be judged. Lastly, a numerical investigation is provided and demonstrates that the algorithms perform adequately on most cases considered.     

Sorting helps for voronoi diagrams

It is well known that, using standard models of computation, Ω(n logn) time is required to build a Voronoi diagram forn point sites. This follows from the fact that a Voronoi diagram algorithm can be used to sort. However, if the sites are sorted before we start, can the Voronoi diagram be built any faster? We show that for certain interesting, although nonstandard, types of Voronoi diagrams, sorting helps. These nonstandard types of Voronoi diagrams use a convex distance function instead of the standard Euclidean distance. A convex distance function exists for any convex shape, but the distance functions based on polygons (especially triangles) lead to particularly efficient Voronoi diagram algorithms. Specifically, a Voronoi diagram using a convex distance function based on a triangle can be built inO (n log logn) time after initially sorting then sites twice. Convex distance functions based on other polygons require more initial sorting.     

Serviceability of Materials in the Tropics

With increasing complexity in the building construction trend and the advancement of building material technology, more building materials and substitutes have evolved and been adopted for use to function together in a building that is supposed to maintain its technical performance during its intended working life. Condition surveys of 450 buildings, face-to-face interviews, and workshops were conducted with industry specialists, to examine the behavior of materials used in facades and wet areas in tropical climates and their estimated costs of maintenance. This paper presents an indicative computational method for the durability of building materials for fa?ades and wet areas in the tropics. Total operations and maintenance costs of the identified materials are also included to provide suggestive maintenance expenditure over the materials’ service life. Natural stone was preferred as a more durable fa?ade material while ceramic and homogeneous tiles proved more economical for wet areas.