Pentoxifylline therapy in human immunodeficiency virus-seropositive persons with tuberculosis: a randomized, controlled trial

Macrophage activation and tumor necrosis factor-alpha (TNF-alpha) production are critical in tuberculosis immunity but may result in increased human immunodeficiency virus (HIV) expression and accelerated HIV disease progression in HIV-infected persons. Pentoxifylline inhibits expression of TNF-alpha and HIV. A double-blind, placebo-controlled study of adjunctive therapy with pentoxifylline (1800 mg/day) as a timed-release formulation was done in Ugandan HIV-infected patients with pulmonary tuberculosis. Subjects had early HIV disease (mean CD4 cell count, 380/microL) and did not receive other antiretroviral drugs. Pentoxifylline resulted in decreased plasma HIV RNA and serum beta 2-microglobulin and, in a subset of moderately anemic patients, improved blood hemoglobin levels. Trends were noted toward reduced TNF-alpha production in vitro and improved performance scores, but these did not reach statistical significance. No effect was noted on body mass, CD4 cell count, or survival. Additional studies of more potent TNF-alpha inhibitors in HIV-positive subjects with tuberculosis are warranted.     

Enzymes of the gamma-glutamyl cycle are programmed in utero by maternal nutrition

Regenerative axon growth in peripheral neurons is accompanied by increased expression of the growth-associated protein GAP-43. We examined the increase of GAP-43 immunoreactivity in DRG neurons following lesions at different distances along the sciatic nerve, using immunocytochemistry. To control for the variable involvement of DRG axons following injury at different sites, injured neurons were identified by retrograde labeling with Fluoro-Gold. GAP-43 labeling was similar for proximal, distal, and far-distal injuries when only injured neurons are considered. Our results stand in contrast to studies which show that GAP-43 upregulation in neurons of the central nervous system occurs only when lesions are made close to the cell body. This suggests that the mechanisms which control GAP-43 expression following injury differ between central and peripheral neurons.     

Check! a generic and specific industrial inspection tool

The authors present an overview of an `inspection and control' package to perform automatic quality control of industrial components, specifically electronic circuit boards. This application has grown out of a set of tools designed initially to aid the development of point distribution models (PDMs) and grey-level models (GLMs) pioneered at the Wolfson Image Analysis Unit in Manchester. These models are both generic and specific. Generic, because they can be applied to most image classification problems; specific, because they aim at the full interpretation of the variability of the objects to be modelled. The underlying vision processing techniques are based on statistical pattern matching. Two synergetic approaches have been followed. The system is trained to recognise the components from either their shape or their grey level appearance or both     

Double cracking in brittle cylindrical specimens subjected to quenching

A series of quench tests on hollow cylindrical specimens made of the machinable ceramic, Pyrophyllite, has been performed. The specimens consistently fractured with two diametrically opposite longitudinal cracks. Finite element analysis indicates that the primary crack occurred at the stage when the strain energy of the cylinder reached its maximum during the thermal transient process, while the secondary crack was caused by stress waves generated following the primary crack. This is supported by experimental observation of the time of fracture and the crack morphology. The work reported here helps to shed light on the fracture criterion for brittle cylindrical components under transient thermal and dynamic loadings.     

Disguise and the structured self-report assessment of psychopathology: I. An analogue investigation.

Explored the utility of disguise in structured self-report assessments of psychopathology in 3 experiments with 370 university students. Exp I used items from the Basic Personality Inventory (BPI); Exp II used the BPI, the Desirability scale of the Personality Research Form—Form E, and 4 criterion measures; and Exp III used 2 of the criterion measures and the BPI. Data indicate that under normal test-taking circumstances, the use of disguised test items was not advantageous. This relationship, however, was moderated by a number of dimensional parameters. When faking response sets in terms of desirability was induced, the use of disguised test item content was not useful. Data are interpreted in terms of the various strategies of test construction underlying the assessment of psychopathology. Results support a rational strategy of test construction emphasizing the use of relevant test item content. It is concluded that, in structured self-report assessments, the most valid results may be obtained through the use of direct questions with cooperative test respondents. (43 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Groupwork and computers: task type and children's performance

Abstract In the majority of British primary schools, children use the computer in groups of two or three. This is partly due to the lack of resources, that is, most classrooms still only have one or two computers to share between around 30 children. Groupwork on computers is also justified for pedagogic reasons. Previous research comparing children working in groups or alone has revealed an advantage for children working in groups although the work undertaken has generally been problem solving tasks. This investigation examined the performance of pairs and individual 6-year old children on a drill and practice program using a pre-test, intervention, post-test design. In comparison to the problem solving evidence, individuals were found to have a significant advantage over pairs during the computer-based task.     

Primary traits of Eysenck's P-E-N system: three- and five-factor solutions

The Eysenck Personality Profiler (EPP), a set of 21 scales measuring primary traits hypothesized to be definers of Neuroticism, Extraversion, and Psychoticism factors, was administered to 229 adults together with the Eysenck Personality Questionnaire--Revised (H. J. Eysenck & S. B. G. Eysenck, 1991) and the Revised NEO Personality Inventory (NEO-PI-R; P. T. Costa & R. R. McCrae, 1992b). Correlations of EPP scales with NEO-PI-R facet scales provided preliminary evidence supporting the convergent and discriminant validity of the EPP scales. However, varimax and targeted validimax factor analyses suggested that some EPP scales were misclassified and that EPP scales could better be understood in terms of the 5-factor model than the intended 3-factor model.     

Benign nonpeptic esophageal strictures. Diagnosis and treatment

This article studies the causes and treatment of benign nonpeptic esophageal strictures. The authors also discuss various therapeutic techniques for esophageal strictures, including esophageal dilatation with various dilators and balloons. Although the goals of stricture therapy are to relieve dysphagia and prevent stricture reoccurrence, only the first of these goals (effective dilatation with bougienage or balloon dilatation) has been achieved. The prevention of stricture reoccurrence remains to be achieved.     

Coherence coding for photonic code-division multiple accessnetworks

We analyze a code-division multiple access technique where information is optically encoded by manipulating the coherence between a pair of transmitted signals. Key features are intrinsic security, operation of the receiver at only the bit rate of a single channel, and reconfiguration without switching optical delays, which are considerable advantages compared to previously proposed CDMA schemes. Experimental results demonstrating the basic operation of the scheme are presented. The performance limitations are calculated and novel implementations are proposed