A Device to Provide Respiratory-Mechanical Unloading

A commercially available and widely used servo-controlled ventilator has been modified to provide controlled inspiratory resistive unloading of the human respiratory system. This is achieved by establishing a positive mouth pressure throughout inspiration in a constant proportion to instantaneous flow, i.e., the ratio of mouth pressure to flow, which defines the "assistance," remaining constant. The performance of this device has been evaluated in four healthy subjects during steady-state, constant-load cycling (20-120 W). It is demonstrated that i) the device can successfully implement controlled degrees of inspiratory assistance on a breath-to-breath basis; ii) the assistance can be sustained over a substantial range of ventilatory drive (i.e., for ventilations up to some 30 1/min) and to an extent which approaches a 100 percent reduction of the normal respiratory resistance. This device should prove useful in experimental and clinical investigations of the respiratory responses to resistive unloading of the respiratory system.     

Muscle mass and fat mass in relation to bone mineral density in very old men and women: the Framingham Heart Study

Aim of the study was investigate the cross-sectional relationship between body composition and bone mineral density (BMD) in very old men and women. The study sample consisted of 504 women and 285 men, aged 72-93 yr, participating in examination 22 (1992-1993) of the Framingham Heart Study. Total body BMD, regional BMD, and soft-tissue body composition was measured by dual-energy X-ray absorptiometry. Both muscle mass and percentage body fat were positively associated with total body BMD in women. After adjustment for age, physical activity, smoking status, estrogen use, and thiazide use, BMD increased with increasing tertile of muscle mass (p = 0.007) and with increasing tertile of percentage body fat (p = 0.0001) in women. In men muscle mass, not percentage body fat, was positively associated with BMD. After adjustment for potential confounders, BMD remained associated with muscle mass only (p = 0.02). These results were similar for leg BMD and arm BMD. The study suggests that the influence of muscle and fat mass on bone mineral density is different between very old men and women.     

Fluctuations in visual neglect after stroke?

Clinical experience suggests that the visual neglect in stroke patients fluctuates over short periods of time. This fluctuation has been variously attributed to fatigue, time of day, previous activities, patient learning and compensation. Such fluctuations have clinical implications for the assessment and rehabilitation of visual neglect but do date no formal study has evaluated the extent of such fluctuation over the course of a day. Twenty-two patients with an acute stroke and 19 patients with convalescent stroke were examined for visual neglect twice on the same day using the Visual Neglect Recovery Index (VNRI), a valid and sensitive measure of the severity of neglect, which could be used to select acute patients for trials of treatment of neglect. The inter-test reliability was extremely high. In contrast to past clinical accounts most patients failed to show significant fluctuation. Although preliminary, this finding suggests that a single assessment of visual neglect, using the VNRI, could help select patients for treatment trials.     

Thermal diffusivity of polymers by the flash method

We have adopted the flash method to the measurement of thermal diffusivity α of polymers in the temperature range 100–400K. The pulsed radiant energy from a flash tube is applied to the ‘front’ side of a suspended sample disc, and α is deduced from the exponential decay time constant of the subsequent transient temperature difference between the ‘front’ and the ‘back’ side, while correction against radiation loss is made by measuring the much longer decay time of the back-side temperature. Calibration runs on polycarbonate (PC) samples of several thicknesses show that the method is quick, precise and fairly accurate, and the results obtained are in reasonable agreement with previous determinations. We have also carried out measurements on polyoxymethylene (POM), poly (vinylidene fluoride) (PVF₂) and poly (ethylene terephthalate) (PET) and computed their thermal conductivities. Results on POM and PVF₂, which are semicrystalline, are analysed in the framework of several two-phase models, and the effect of crystallization (produced by annealing) on the glass transition behaviour of PET has also been studied.     

A Randomized Linear-Work EREW PRAM Algorithm to Find a Minimum Spanning Forest

We present a randomized EREW PRAM algorithm to find a minimum spanning forest in a weighted undirected graph. On an n -vertex graph the algorithm runs in o(( log n) ^{1+ ɛ} ) expected time for any ɛ >0 and performs linear expected work. This is the first linear-work, polylog-time algorithm on the EREW PRAM for this problem. This also gives parallel algorithms that perform expected linear work on two general-purpose models of parallel computation—the QSM and the BSP.     

Why quality of life measures should be used in the treatment of patients with respiratory illness

Treatment of airways disease is directed towards improving patients' health and well-being. Measurements of airways function do not reflect all the disease activity present in the airways that may affect the patient. Spirometry correlates poorly with health. Physicians appear to estimate their patients' health using criteria different from the patients themselves. Quality of life questionnaires provide a method of quantifying the effect of disease on patients' lives. They can summarize a number of aspects of the disease and provide an overall estimate of the effect of disease and benefits due to therapy. They have the potential to identify a threshold response to treatment that may be considered "worthwhile", and allow comparison between therapies with respect to the health gain that each provides.     

Gaussian-beam profile shaping by acousto-optic Bragg diffraction

We study how Gaussian laser-beam profiles can be modified into a desired form using acousto-optic Bragg diffraction. By exploiting the angular dependence of Bragg diffraction of plane waves by acoustic gratings, we demonstrate that the conversion from a Gaussian-profile beam into either a near-field or a far-field flattop profile is possible.