Promyelocytic blast crisis of chronic myelogenous leukaemia with translocations (9;22) and (15;17)

The murine monoclonal antibody A7 (MAb A7) is reactive against most human gastric cancer cell lines. Using a nude mouse peritoneal dissemination model of human gastric cancer, we investigated targeted chemotherapy using a conjugate of neocarzinostatin (NCS) with MAb A7 (A7-NCS). After demonstrating cytotoxicity of the complex against the human gastric cancer cell line MKN45 in vitro, we intraperitoneally injected A7-NCS, NCS or saline into nude mice bearing peritoneally disseminated human gastric cancer. A7-NCS inhibited peritoneal dissemination significantly more effectively than NCS. MAb A7 may prove to be an effective carrier for antineoplastic drugs in patients with peritoneal dissemination of gastric cancer.     

Evaluation of the effect of a maternal rearing system on the odour profile of meat from suckling lamb

The aim was to evaluate the effect of maternal rearing system on the chemical composition and odour profile of meat from suckling lamb. Twenty-four single male suckling lambs raised exclusively on maternal milk came from two rearing systems (extensive and intensive), and from Castellana and Churra breeds. The fatty acid composition of lamb meat from both breeds was affected by the rearing system, and Churra lamb reared under the extensive system had noticeable changes in odour attributes as detected by panellists and an electronic nose. Using partial least squares-discriminant analysis, the electronic nose was able to discriminate accurately between samples of Churra and Castellana meat according to their production system. However, it was not able to correctly classify meat samples from the extensive and intensive systems when both breeds were analysed together. The results suggest a significant effect of the rearing system and breed on suckling lamb meat quality traits.     

Decreased capacity for type-specific-antigen synthesis accounts for high prevalence of nontypeable strains of group B streptococci in Mexico

The low incidence of group B streptococcal (GBS) invasive neonatal disease in Mexico has been attributed to the low prevalence of serotype III strains, a major serotype in developed countries. In addition, nontypeable strains account for 12% of the isolates in Mexico and < 1% of the isolates in the United States. In this study, 57 GBS isolates (28 nontypeable by the Lancefield procedure) from carrier and infected neonates and women from Mexico were also examined for the presence of type-specific antigen by an enzymatic procedure using N-acetylmuramidase digestion of the cell wall to release soluble type-specific antigen. Of the 28 nontypeable strains from Mexico, 23 were typeable by the enzyme extraction procedure, with serotype III being the predominant serotype in invasive disease. These results suggest that nontypeable isolates of GBS should be further examined by the enzymatic extraction procedure to determine the presence of type-specific antigen. Furthermore, these limited results suggest that serotype III is likely a major serotype in invasive disease also in Mexico.     

X‐Ray Spectroscopic Investigation of Chlorinated Graphene: Surface Structure and Electronic Effects

Chemical doping of graphene represents a powerful means of tailoring its electronic properties. Synchrotron‐based X‐ray spectroscopy offers an effective route to investigate the surface electronic and chemical states of functionalizing dopants. In this work, a suite of X‐ray techniques is used, including near edge X‐ray absorption fine structure spectroscopy, X‐ray photoemission spectroscopy, and photoemission threshold measurements, to systematically study plasma‐based chlorinated graphene on different substrates, with special focus on its dopant concentration, surface binding energy, bonding configuration, and work function shift. Detailed spectroscopic evidence of C–Cl bond formation at the surface of single layer graphene and correlation of the magnitude of p‐type doping with the surface coverage of adsorbed chlorine is demonstrated for the first time. It is shown that the chlorination process is a highly nonintrusive doping technology, which can effectively produce strongly p‐doped graphene with the 2D nature and long‐range periodicity of the electronic structure of graphene intact. The measurements also reveal that the interaction between graphene and chlorine atoms shows strong substrate effects in terms of both surface coverage and work function shift.     

Numerical modeling of gland seal erosion in a geothermal turbine

Excessive erosion of the low-pressure rotor end gland seal of a 25 MWe geothermal turbine produced a partial loss of turbine vacuum that degraded cycle efficiency. This study used computational fluid dynamics (CFD) to identify the causes of erosion and the optimal steam seal system flow conditions for reducing the erosion problem. The predictions were based upon a numerical calculation using a commercial CFD code (Adapco Star-CD) to model the rotor end gland seal with a steam flow containing hard solid particles. The results confirmed that flow conditions play a major role in rotor gland seal erosion. By changing steam seal flow pressures to vary flow, it was confirmed that there is a threshold seal flow condition below which erosion does not occur, or is minimized. Optimizing the rotor end gland seal supply pressure and intercondenser pressure reduced the turbulent flow kinetic energy by 49%, with a corresponding decrease in the erosion rate of the rotor gland seal surface. The erosion rate is related directly to the particle velocity and turbulent flow kinetic energy. Recommendations are provided for adjusting the rotor end gland seal system to avoid erosion.     

New method for COP optimization in water- and air-cooled single and double effect LiBr-water absorption machines

In this work a new method to optimize the COP in water- and air-cooled single and double effect LiBr/H₂O absorption chillers is proposed. This method determines the effect of condensation temperatures and the solution concentration variation on COP, clearly defining the crystallization limit for different scenarios. This limit is especially important in the design of air-cooled chillers. Taking this into account a simulation program has been developed to calculate the optimum COP. In the case of parallel flow double effect chillers this program estimates not only the optimum COP but also the percentage of refrigerant vapour generated in the high and low temperature desorbers in terms of the condensation temperature. Additionally it provides the mass flow of the solution that should be distributed to each desorber to attain the desired variation in solution concentration.