Grooved substrata facilitate in vitro healing of completely divided flexor tendons

Multiple grooved substrata with groove depth 5 m were found to facilitate the healing of completely divided rat flexor tendons in vitro. Sections of tendons cultured on plain substrata showed only partial healing with incompletely sealed epitenon layers and immature thin collagen fibres. Tendons cultured on patterned substrata healed with complete restoration of the epitenon layer and reconstitution of the internal structure of collagen fibres. Epitenon fibroblasts isolated from the surface of rat flexor tendons were shown to be more sensitive to topographical features than fibroblasts of the same size BHK fibroblasts. They remained more elongated and better aligned to the groove direction than BHK cells. Multiple grooved substrata facilitated epitenon cell movement. Cells were found to move with higher speed on patterned substrata than on plain substrata. In summary, we conclude that the use of multiple grooved substrata promotes tendon healing in vitro and may find application in clinical practice in tendon repair.     

Are only repeated triplets guilty?

It is well known that in some places of the human genome one finds a variable number of tandem repeats of trinucleotides; it is now commonly acknowledged that in many cases an excessive expansion of such a number is the cause of nervous system diseases. Moreover there exist cases of genetic disorders linked with loci where a variable number of tandem repeats of sequences longer than three bases has been found. The abnormal number of these repeats in few cases has been associated with the onset of the disease. Considering the above facts, we have performed an extensive study of published sequences of genes connected with various diseases. We have examined, inside or near those genes, all possible tandem repeats. The analysis has led to the detection of a large number of repeats of both triplets and longer sequences, many of which, as far as we know, had not been pointed out before. The results of our analysis lead us to put forward the hypothesis that in more cases than those till now established, a variable number of tandem repeats of generic sequences, not only of triplets, could be associated with disease onset. Finally we suggest to allocate experimental researches for all the possible tandem repeats and their possible correlation with the neurodegenerative disorders and with other kinds of syndromes.     

The solid-state rearrangement of the Wells-Dawson K6P2W18O62·10H2O to a stable Keggin-type heteropolyanion phase: a catalyst for the selective oxidation of isobutane to isobutene

The thermal and structural stability of the Wells-Dawson-type heteropoly compound K₆P₂W₁₈O₆₂·10H₂O was examined by FT-IR spectroscopy, X-ray powder diffraction, thermogravimetric analysis and HRTEM. It was found that calcination at temperatures higher than 850 K led to the formation of a Keggin-type compound K₃PW₁₂O₄₀, containing small amounts of an additional phase originated from the high-temperature interaction between potassium phosphate (K₃PO₄ formed during the decomposition of the K₆P₂W₁₈O₆₂·10H₂O) and the Keggin-type compound itself. The Keggin-type product showed a higher activity in the selective oxidative dehydrogenation of isobutane to isobutene compared to both the Wells-Dawson precursor and to pure, authentic K₃PW₁₂O₄₀. This higher activity can be tentatively attributed to the presence of an amorphous layer of unknown stoichiometry at the surface of the thermally rearranged Wells-Dawson compound.     

Competition between brittle fracture and plastic collapse in the failure of thin rectangular panels

A centre-cracked panel of elastic-plastic material of unit thickness is loaded remotely by an uniaxial traction acting along its longitudinal axis. Making use of the Dugdale-Barenblatt model, the size of the plastic zones ahead of the crack tips can be obtained by equilibrium considerations. Connected to , a generalised elastic-plastic stress intensity factor K is defined which, as 0, approaches the ordinary elastic one. Once the critical values W _c or K _c at the onset of the unstable propagation of the crack have been specified, the residual-strength curves for plane stress state can be easily deduced. Moreover, conditions are sought for which ductile fracture, brittle fracture or plastic collapse takes place.     

Graph-based quadratic optimization: A fast evolutionary approach

Quadratic optimization lies at the very heart of many structural pattern recognition and computer vision problems, such as graph matching, object recognition, image segmentation, etc., and it is therefore of crucial importance to devise algorithmic solutions that are both efficient and effective. As it turns out, a large class of quadratic optimization problems can be formulated in terms of so-called “standard quadratic programs” (StQPs), which ask for finding the extrema of a quadratic polynomial over the standard simplex. Computationally, the standard approach for attacking this class of problems is to use replicator dynamics, a well-known family of algorithms from evolutionary game theory inspired by Darwinian selection processes. Despite their effectiveness in finding good solutions in a variety of applications, however, replicator dynamics suffer from being computationally expensive, as they require a number of operations per step which grows quadratically with the dimensionality of the problem being solved. In order to avoid this drawback, in this paper we propose a new population game dynamics (InImDyn) which is motivated by the analogy with infection and immunization processes within a population of “players.” We prove that the evolution of our dynamics is governed by a quadratic Lyapunov function, representing the average population payoff, which strictly increases along non-constant trajectories and that local solutions of StQPs are asymptotically stable (i.e., attractive) points. Each step of InImDyn is shown to have a linear time/space complexity, thereby allowing us to use it as a more efficient alternative to standard approaches for solving StQPs and related optimization problems. Indeed, we demonstrate experimentally that InImDyn is orders of magnitude faster than, and as accurate as, replicator dynamics on various applications ranging from tree matching to image registration, matching and segmentation.     

Performance of One-Round Walks in Linear Congestion Games

We investigate the approximation ratio of the solutions achieved after a one-round walk in linear congestion games. We consider the social functions Sum, defined as the sum of the players’ costs, and Max, defined as the maximum cost per player, as a measure of the quality of a given solution. For the social function Sum and one-round walks starting from the empty strategy profile, we close the gap between the upper bound of \(2+\sqrt{5}\approx 4.24\) given in Christodoulou et al. (Proceedings of the 23rd International Symposium on Theoretical Aspects of Computer Science (STACS), LNCS, vol. 3884, pp. 349–360, Springer, Berlin, 2006) and the lower bound of 4 derived in Caragiannis et al. (Proceedings of the 33rd International Colloquium on Automata, Languages and Programming (ICALP), LNCS, vol. 4051, pp. 311–322, Springer, Berlin, 2006) by providing a matching lower bound whose construction and analysis require non-trivial arguments. For the social function Max, for which, to the best of our knowledge, no results were known prior to this work, we show an approximation ratio of \(\Theta(\sqrt[4]{n^{3}})\) (resp. \(\Theta(n\sqrt{n})\)), where n is the number of players, for one-round walks starting from the empty (resp. an arbitrary) strategy profile.     

PolyMAX,a Mobile WiMAX module for the ns-2 simulator with QoS and AMC support

In this paper, we present the PolyMAX module which enhances network simulator 2 (ns-2), the most popular network simulator used in academia, to provide one of the most complete simulation tools to evaluate the performance of Mobile WiMAX networks. PolyMAX is based on the National Institute of Standards and Technology (NIST) module and our specific contributions consist on the design and implementation of the Quality of Service (QoS) classes and QoS management messages, the uplink access grant-request mechanisms, Adaptive Modulation and Coding, and a scheduler handling all five WiMAX QoS classes. We also present validation results for the different components of our module and typical WiMAX simulation scenarios illustrating its flexibility and some of its features. The PolyMAX module represents an important tool enabling researchers to easily implement their Mobile WiMAX scheduling and Adaptive Modulation and Coding (AMC) algorithms and accurately evaluate their performance for realistic scenarios.     

The joint Gateway Placement and Spatial Reuse Problem in Wireless Mesh Networks

A Wireless Mesh Network (WMN) is composed of multiple Access Points (APs) that are connected together using the radio channel and by a limited number of gateway APs connected to the Internet. In this paper, we address the problem of gateway placement that consists of minimizing the number of gateways while satisfying system performance requirements. Along with the placement problem, the formulation includes joint routing and scheduling to account for the problem of interference and to enable spacial reuse. The problem, which we coined GPSRP (Gateway Placement and Spatial Reuse Problem), allows a much more efficient use of the available resources and reduces overall gateway costs. This article presents for the first time a mathematical formulation of the problem and discusses its advantages and limitations with respect to other approaches.     

A data fusion and spatial data analysis approach for the estimation of wheat grain nitrogen uptake from satellite data

The selection of the optimal band combination for the estimation of specific crop variables is a key aspect in order to obtain reliable estimation of in-field variability from multi- and hyperspectral remote-sensing data. The selection of the bands is strongly influenced by the phenological stage of the crop at the acquisition time. In this work, the influence of the growing stage on the combination of spectral bands related to grain nitrogen (N) uptake in wheat was evaluated using multispectral (Satellite Pour l’Observation de la Terre – SPOT) and hyperspectral (Compact High Resolution Imaging Spectrometer – CHRIS-PROBA) satellite images at different growth stages over two wheat growth seasons in central Italy. In order to identify the more appropriate covariates (spectral bands) for each phenological stage, stepwise regression with backward selection was combined with stepwise variance inflation factors (VIFs) analysis and linear mixed effect model (LMEM). The results obtained in this study suggest that the spectral region most related to N uptake varies over the growing season of the wheat crop. For SPOT data, near-infrared (NIR) region was selected at all the phenological stages in both growing seasons, except for the latest stage, with low chlorophyll content due to the onset of senescence, in which the red band was selected. At stem elongation, the shortwave infrared (SWIR) band of SPOT data was also selected. At this stage, the best N estimation accuracy was obtained using an LMEM (root mean square error, RMSE = 0.012 t ha^?1). The inclusion of a spatial component in the estimation model by means of LMEMs provided a more accurate estimation than ordinary least square (OLS) models at all growth stages. The test carried out with CHRIS-PROBA data at the fourth stage confirmed the importance of NIR and in particular of the red-edge region for N uptake prediction. A novel methodology is proposed, which involves two crucial aspects in the context of the use of remote-sensing data in precision agriculture: i) the standardization of the spatial resolution for in-field and satellite data by a geostatistical data technique (data fusion); and ii) the selection of the most appropriate spectral bands for each phenological stage, taking into account both correlation with the target variable and collinearity.     

An Acoustic Network Navigation System

This work describes a system for acoustic‐based navigation that relies on the addition of localization services to underwater networks. The localization capability has been added on top of an existing network, without imposing constraints on its structure/operation. The approach is based on the inclusion of timing information within acoustic messages through which it is possible to know the time of an acoustic transmission in relation to its reception. Exploiting such information at the network application level makes it possible to create an interrogation scheme similar to that of a long baseline. The advantage is that the nodes/autonomous underwater vehicles (AUVs) themselves become the transponders of a network baseline, and hence there is no need for dedicated instrumentation. The paper reports at sea results obtained from the COLLAB–NGAS14 experimental campaign. During the sea trial, the approach was implemented within an operational network in different configurations to support the navigation of the two Centre for Maritime Research and Experimentation Ocean Explorer (CMRE OEX) vehicles. The obtained results demonstrate that it is possible to support AUV navigation without constraining the network design and with a minimum communication overhead. Alternative solutions (e.g., synchronized clocks or two‐way‐travel‐time interrogations) might provide higher precision or accuracy, but they come at the cost of impacting on the network design and/or on the interrogation strategies. Results are discussed, and the performance achieved at sea demonstrates the viability to use the system in real, large‐scale operations involving multiple AUVs. These results represent a step toward location‐aware underwater networks that are able to provide node localization as a service.