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101.
Ana Paula Macedo ;Debora Taffarel Ferrari ;Roberta C Shimano ;Joao Paulo Mardegan Issa ;Alceu Afonso Jordao ;Antonio Carlos Shimano 《机械工程与自动化:英文版》2014,(6):542-546
The aim of this study is to evaluate the ability of physical training in the maintenance of muscle strength in rats with HFD (high-fat diet) after OVX (ovariectomy). Eighty Wistar rats are at eight weeks of age and weight 200 g which divided into 8 groups (n = 10) and treated for 12 weeks: GA: OVX + ND (normal diet), GB: OVX + ND + training, GC: sham + ND, GD: sham + ND + training, GE: OVX + HFD, GF: OVX + HFD + training, GG: sham + HFD and GH: sham + HFD + training. HFD consists of standard ration for rats with addition of 30% lipids. In training groups, physical training five training/week was conducted on a treadmill with adaptation period of three weeks up to 18 m/s for one hour, training were performed for 12 weeks. The sedentary animals remained in individual box. To analyze the effects of training and diet, tensile strength tests of the gastrocnemius muscles were conducted: the speed of 0.1 mm/min. Analysis of variance was performed to compare groups. The mean (SD) obtained for the maximum load (N) were: GA 57.77 (6.89), GB 62.74 (5.07), GC 49.45 (6.06), GD 59.42 (5.26) and GE 55.58 (4.72), GF 62.50 (4.56), GG 58.35 (4.54) and GH 56.67 (5.87), respectively. There were no differences for maximum load between surgeries (p = 0.004) and between treatments (p = 0.000). Differences were found also for the relationship surgery diet treatment (p = 0.007). For the variable stiffness (N/mm), there were not statistically significant differences: GA 5.03 (0.72), GB 5.08 (1.09), GC 5.17 (0.53), GD 5.35 (0.80), GE 5.52 (1.20), GF 5.36 (1.07), GG 4.83 (1.03) and GH 5.40 (0.73). For the toughness (N/mm), there were differences between treatments (p = 0.010) and the ratio diet treatment (p = 0.024): GA 455.00 (107.21), GB 541.96 (126.80), GC 394.97 (84.67), GD 566.90 (157.07); GE 424.63 (113.03), GF 478.07 (106.03); GG 517.44 (98.65? 相似文献
102.
Synthesis,Pharmacological Evaluation,and Docking Studies of Novel Pyridazinone‐Based Cannabinoid Receptor Type 2 Ligands 下载免费PDF全文
Dr. Giulio Ragusa Dr. Serena Bencivenni Dr. Paula Morales Dr. Tyra Callaway Dr. Dow P. Hurst Dr. Battistina Asproni Dr. Stefania Merighi Dr. Giovanni Loriga Prof. Gerard A. Pinna Prof. Patricia H. Reggio Prof. Stefania Gessi Prof. Gabriele Murineddu 《ChemMedChem》2018,13(11):1102-1114
In recent years, cannabinoid type 2 receptors (CB2R) have emerged as promising therapeutic targets in a wide variety of diseases. Selective ligands of CB2R are devoid of the psychoactive effects typically observed for CB1R ligands. Based on our recent studies on a class of pyridazinone 4‐carboxamides, further structural modifications of the pyridazinone core were made to better investigate the structure–activity relationships for this promising scaffold with the aim to develop potent CB2R ligands. In binding assays, two of the new synthesized compounds [6‐(3,4‐dichlorophenyl)‐2‐(4‐fluorobenzyl)‐cis‐N‐(4‐methylcyclohexyl)‐3‐oxo‐2,3‐dihydropyridazine‐4‐carboxamide ( 2 ) and 6‐(4‐chloro‐3‐methylphenyl)‐cis‐N‐(4‐methylcyclohexyl)‐3‐oxo‐2‐pentyl‐2,3‐dihydropyridazine‐4‐carboxamide ( 22 )] showed high CB2R affinity, with Ki values of 2.1 and 1.6 nm , respectively. In addition, functional assays of these compounds and other new active related derivatives revealed their pharmacological profiles as CB2R inverse agonists. Compound 22 displayed the highest CB2R selectivity and potency, presenting a favorable in silico pharmacokinetic profile. Furthermore, a molecular modeling study revealed how 22 produces inverse agonism through blocking the movement of the toggle‐switch residue, W6.48. 相似文献
103.
The synthesis, structural characterization, photo and electroluminescence, thermal and electrochemical properties of a new fluorinated fluorene-containing copolymer are described. The copolymer is formed by alternating mers of [2,3,5,6 tetrafluoro-1,4 phenylene] and [9,9′-dihexyl-2,7 fluorene] and emits blue light with low turn on voltages. The EL performance of the fluorinated copolymer was superior to those of the non-fluorinated analog copolymer and of the corresponding poly(9,9′dihexyl-2,7 polyfluorene) homopolymer. 相似文献
104.
Free-radical scavenging capacity and reducing power of wild edible mushrooms from northeast Portugal: Individual cap and stipe activity 总被引:6,自引:0,他引:6
Isabel C.F.R. Ferreira Paula Baptista Miguel Vilas-Boas Lillian Barros 《Food chemistry》2007,100(4):1511-1516
The antioxidant properties of two wild edible mushroom species from the northeast of Portugal, Lactarius deliciosus (L.) Gray and Tricholoma portentosum (Fr.) Quél., were evaluated. Methanolic extracts from the entire mushroom, the cap and the stipe, separately, were screened for their reducing power and free radical scavenging capacity by chemical assays. The total phenolic content was determined, in order to assess its effect on the extract’s antioxidant activity. Both two species showed antioxidant potential; but L. deliciosus proved to be more active. The portion of the mushroom used had an influence on the results obtained, with the cap methanolic extracts exhibiting the greatest antioxidant effect. 相似文献
105.
Almeida G Figueiredo A Rôla M Barros RM Gibbs P Hogg T Teixeira P 《Journal of food protection》2007,70(7):1710-1716
Seventy raw milk cheeses made in different regions of Portugal, both hard and soft varieties, made with cow's, ewe's, or goat's milk or combinations of these, were sampled within their quoted shelf lives for microbiological safety. On the basis of the presence or numbers of Escherichia coli, E. coli O157, Staphylococcus aureus, Salmonella, and Listeria monocytogenes, cheeses were categorized as satisfactory, acceptable, unsatisfactory, or unacceptable and potentially hazardous. Twenty-two of the 70 cheeses were classified as satisfactory or acceptable. Thirty-seven of the cheeses were considered unsatisfactory because of the presence of E. coli, S. aureus, or both, while 11 of the cheeses were graded as unacceptable and potentially hazardous because of the presence of excessive numbers of S. aureus, E. coli, or L. monocytogenes and the presence of Salmonella in three of these. All cheeses graded as unacceptable and potentially hazardous were soft or semisoft cheeses made with ewe's and goat's milk, with the exception of two hard cheeses made with cow's milk. E. coli O157 was not detected in any of the cheeses. According to the present results, it seems that the presence or counts of pathogenic or indicator organisms in raw milk cheeses cannot be related to the processing conditions, milk type, or region of production. 相似文献
106.
Roasting,Grinding, and Storage Impact on Thermodynamic Properties and Adsorption Isotherms of Arabica Coffee 下载免费PDF全文
107.
v. Pohl R. Trendelenburg Zimmermann E. Brüche S. Nickel Zycha Liese Schulz Graf A. Troche T. Perkitny M. Lüdtke Frey-Wyssling K. Storch Otto Kratky A. v. Wacek Finkbeiner K. Storch Munds Paula Sarten Ernst Tschanter A. Kraus R. Lechner Schaile Thiele W. Küch Kräß Hengerer Kollmann A. Nowak 《Holz als Roh- und Werkstoff》1940,3(4):128-136
Ohne Zusammenfassung 相似文献
108.
Tíffany Marín Daniela Ortega Paula Montoya Oscar Arnache Jorge Calderón 《Journal of Applied Electrochemistry》2014,44(12):1401-1410
This paper shows how magnetic nanoparticles are produced by electrochemical synthesis using a low carbon steel bar as an anode and 100 mA cm?2 electric perturbations at room temperature. Two different kinds of salts, (CH3)4NCl and NaCl, were used to prepare the supporting electrolyte solutions. This allowed a comparison to be made between a surfactant and common salt, and allowed their influence on particle size to be analyzed. Additionally, mixtures of water and ethanol were added to the electrolyte solution in order to improve particle size distribution. The nanoparticle samples were characterized by X-ray diffraction, TEM, magnetization measurements, and Raman and Mössbauer spectroscopy. The results showed that after an optimized time of 10 min, the nanoparticles obtained in all the evaluated electrolytes were mainly magnetite (Fe3O4). The particles were between 8 and 10 nm in size. Depending on the nature of the electrolyte, the magnetite nanoparticles exhibited high purity and stoichiometry. The presence of ethanol in the electrolyte avoided particle agglomeration during the formation of magnetite. When the magnetic nanoparticles were exposed to an external magnetic field they showed superparamagnetic behavior and negligible coercivity. Such qualities are extremely useful for applications like ferrofluid precursors. 相似文献
109.
Bradizza Clara M.; Maisto Stephen A.; Vincent Paula C.; Stasiewicz Paul R.; Connors Gerard J.; Mercer Nicole D. 《Canadian Metallurgical Quarterly》2009,77(6):1147
Few investigators studying alcohol abuse among individuals with a severe mental illness (SMI) have examined predictors of posttreatment alcohol outcomes. In the present study, a multivariate approach based on a theoretical model was used to study the relationship between psychosocial factors and post-treatment-initiation alcohol use. Predictors of alcohol use outcomes were examined in 278 individuals diagnosed with a current schizophrenia-spectrum or bipolar disorder and an alcohol use disorder (AUD). At 6-months follow-up, 144 of 228 available participants (63%) had good clinical outcomes. The results of structural equation modeling indicated that type of pretreatment residential setting was directly related to treatment, with participants who lived in supervised settings (41%) reporting significantly more days of treatment (β = .34, p 相似文献
110.