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121.
122.
Pete Simpson 《Computer Fraud & Security》2003,2003(10):6-8
Identification is becoming increasingly problematic in the halls of smoke and mirrors we call ‘cyberspace’. The identity question raises its head in the context of the origin of mass-mailing viruses and worms; the relentless avalanche of spam; electronic identity theft; Internet fraud and cybersquatters. How do we recognise and respond to email address spoofing? How should we react to the evil spammer? Why must we remain vigilant in defence of our financial details and what is our recourse in the event of identity theft and fraud? How we choose to resolve these issues could determine our future freedom of use of the Internet, and a clearer understanding should allow us to navigate safely some potentially hazardous waters ahead. 相似文献
123.
While the majority of CPUs now sold contain multiple computing cores, current grid computing systems either ignore the multiplicity of cores, or treat them as distinct, independent machines. The latter approach ignores the resource contention present between cores in a single CPU, while the former approach fails to take advantage of significant computing power. We provide a decentralized resource management framework for exploiting multi-core nodes to run multi-threaded applications in peer-to-peer grids. We present two new load-balancing schemes that explicitly account for the resource sharing and contention of multiple cores, and propose a parameterized performance prediction model that can represent a continuum of resource sharing among cores of a CPU. We use extensive simulation to confirm that our two algorithms match jobs with computing nodes efficiently, and balance load during the lifetime of the computing jobs. 相似文献
124.
High-throughput automated luminescent magnetic particle-based immunoassay to monitor human exposure to pyrethroid insecticides 总被引:1,自引:0,他引:1
We have developed a sensitive, automated, competitive chemiluminescent immunoassay for the detection of 3-phenoxybenzoic acid (3-PBA), a metabolite common to many pyrethroid insecticides. The system uses a competitive hapten-protein conjugate that has been labeled with an acridinium ester as the chemiluminescent probe and secondary antibody-coated paramagnetic particles for the separation. After the immunoassay reagents and samples are combined for the competitive incubation step, a fully automated system is used to load the postincubation mixture into a delivery cuvette, facilitating the subsequent magnetic separation of the immunocomplex and the measurement of chemiluminescent signal for quantification. The immunoassay format described here supports the requirement for high throughput necessary for monitoring large numbers of samples in population-based studies. The optimized immunoassay was more sensitive than the conventional enzyme immunoassay in buffer (IC(50) = 0.1 and 2 microg/L, respectively). The mixed-mode solid-phase extraction used for sample preparation to reduce possible urinary matrix effects allowed the accurate measurement of 3-PBA levels as low as 1 microg/L. The automated chemiluminescent immunoassay described here is sensitive, simple to use, and more rapid than the previously reported standard microplate assay. 相似文献
125.
Current developments in SELDI affinity technology 总被引:29,自引:0,他引:29
The overall history and recent advancements in Surface-Enhanced Laser Desorption/Ionization (SELDI) affinity technology is reviewed. A detailed account of SELDI technology, utilizing Immobilized-Metal Affinity surfaces, pseudo-specific chromatographic surfaces, and biospecific interactive surfaces, is presented with particular emphasis placed upon examination of fundamental characteristics as well as specific applications for each. Finally, a detailed review of the specific use of such affinity surfaces in fundamental aspects of clinical, process, and research proteomics activity is presented. 相似文献
126.
Eiler William J. A. II; Masters Jacob; McKay Pete F.; Hardy Lathen III; Goergen Josh; Mensah-Zoe Boikai; Seyoum Regat; Cook Jason; Johnson Nathan; Neal-Beliveau Bethany; June Harry L. 《Canadian Metallurgical Quarterly》2006,14(3):361
Differences in the mesolimbic dopamine (DA) pathway that regulates alcohol preference may also increase sensitivity to the reinforcing effects of other drugs of abuse. In the present study, the curve-shift (rate-frequency) paradigm was used to quantify the interaction of amphetamine with the rewarding effects of lateral hypothalamic brain stimulation reward (BSR) in alcohol-preferring (P) and -nonpreferring (NP) rats. The role of D? and D? DA receptors of the nucleus accumbens (NAcc) in mediating the reward-potentiating effects of amphetamine was also determined. Animals were tested with randomly administered amphetamine (0.25, 0.75, 1.25 mg/kg ip), DA-receptor antagonists (SCH 23390 [2.0 μg, 5.0 μg]; eticlopride [2.0 μg, 5.0 μg]), or a combination of the 2 (SCH 23390 [2.0 μg, 5.0 μg] + 0.75 mg/kg amphetamine; eticlopride [2.0 μg, 5.0 μg] + 0.75 mg/kg amphetamine). Amphetamine produced comparable dose-related leftward shifts in the rate-frequency function for both P and NP rats, with a greater than 60% reduction observed in BSR threshold. On intervening days, baseline threshold was unaltered between tests and similar between rat lines. Unilateral infusion in the NAcc of either the D? or D? receptor antagonist produced rightward shifts in the rate-frequency function of amphetamine, completely reversing-attenuating its reward-enhancing effects. The results demonstrate that amphetamine produces similar threshold-lowering effects in both P and NP rats and that the reward-potentiating effects of amphetamine do not correlate with alcohol preference under the conditions of the present study. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
127.
Benjamin Kowalski Jamesa Stokes Patrick E. Albert Pete E. Lauer Douglas E. Wolfe 《Journal of the American Ceramic Society》2023,106(6):3911-3921
Jet engine components need protective coatings to function against both high-temperature and environmental effects. Ingested calcium–magnesium–aluminosilicates (CMAS) dust particulates are extremely detrimental to the life of the coatings. However, many methods exist to investigate the infiltration of CMAS into these coatings with each method exploring a different aspect of the degradation process. To probe the overlap in these methods, this study focuses on the effect of grain size, areal density, and aspect ratio on the infiltration of CMAS into yttria stabilized zirconia. The infiltration depths ranged from 6 up to 85 µm depending on the test conditions. 相似文献
128.
Conservative tracer experiments, and spatial temperature and dissolved oxygen mapping within four subsurface treatment wetlands employed in this study demonstrated the importance of supplemental aeration and vegetation in reducing preferential flows in cold climate treatment wetlands. Four constructed wetlands, employing horizontal subsurface flow were used to treat dairy wastewater in a 2 x 2 factorial design consisting of two wetland cells with vegetation and two with supplemental aeration. Four tracer studies were conducted between November 2004 and May 2005. Two key observations were made, demonstrating that vegetation and aeration can be utilized in cold regions to prevent clogging and freezing, thereby reducing preferential flow paths which can reduce treatment efficiencies: (1) vegetation contributed to thermal protection and (2) aeration increased temperature and mixing. A comparison of multiple wetland cells with varying flow rates showed that the use of pore volume in tracer response curves was a better indicator of preferential flows than other indicators including volumetric efficiency, hydraulic efficiency and number of continuosly stirred tank reactors (CSTRs). This research helps further establish how constructed wetlands are a viable tool for treating wastewater in cold climates. 相似文献
129.
Alan S. Abrahams Eloise Coupey Eva X. Zhong Reza Barkhi Pete S. Manasantivongs 《Expert systems with applications》2013,40(8):2777-2791
As marketing communications proliferate, the ability to target the right audience for a message is of ever-increasing importance. Audience targeting practices for mass media, both in research and in industry, have tended to emphasize demographics, behavior, and other characteristics of customer groups as the bases for matching communications to audiences. These approaches overlook the opportunity to leverage the nature of advertising content, by automatically matching advertisement content to appropriate media channels and target audience. We model the semantic and sentiment content of advertisements with 103 variables. Based on these variables, a neural network classifier is used to assign advertisements to groups that represent different media channels. In its ability to classify unseen advertisements, the model outperforms the classification result generated by a random model, by 100–300%. This method also enables us to identify and describe divergent advertisement characteristics, by industry. 相似文献
130.
Sutcliffe Alistair Sawyer Pete Stringer Gemma Couth Samuel Brown Laura J. E. Gledson Ann Bull Christopher Rayson Paul Keane John Zeng Xiao-jun Leroi Iracema 《Requirements Engineering》2020,25(1):1-20
Requirements Engineering - We report experience in requirements elicitation of domain knowledge from experts in clinical and cognitive neurosciences. The elicitation target was a causal model for... 相似文献