Generalized Hough Transform Using Regions with Homogeneous Color

A novel generalized Hough transform algorithm which makes use of the color similarity between homogeneous segments as the voting criterion is proposed in this paper. The input of the algorithm is some regions with homogeneous color. These regions are obtained by first pre-segmenting the image using the morphological watershed algorithm and then refining the resultant outputs by a region merging algorithm. Region pairs belonging to the object are selected to generate entries of the reference table for the Hough transform. Every R-table entry stores a relative color between the selected region pairs. This is done in order to compute the color similarity and in turn generate votes during the voting process and some relevant information to recover the transformation parameters of the object. Based on the experimental results, our algorithm is robust to change of illumination, occlusion and distortion of the segmentation output. It recognizes objects which were translated, rotated, scaled and even located in a complex environment.     

Flood control management system for reservoirs

Flood disaster is one of the most damaging natural disasters in China, with annual average losses more than 200 billion yuan in recent years. After 1995 floods in the Liaohe River and 1998 floods in the Yangtze River, the governments from national to local have realized that the flood control operation of reservoirs can play a major role in alleviating flood losses but there are some problems in flood control management for reservoirs. Most of the existing flood control management systems for reservoir were established for special purposes and are lack of data share and communication with governments, it is very difficult for decision-making departments to get real-time information in short time. Thus, a national programming about flood control management system for reservoirs is presented. The paper is a summary of the outcome of national programming about the flood control management system for reservoirs in China. The background, objectives, main challenges and main contents of the programming are introduced. The main focus is on the issues of the software integration flood control management system for reservoirs. Emphasis is concentrated on the flowchart design of the system and its core components. The current system can be applied to a river control center or a single reservoir because of using the national standard databases and easily integrated into the national flood control system in the future. An application system is briefly introduced in order to understand the system.     

Investigation of electrostrictive polymers as actuators for mesoscale devices

Abstact This paper presents an investigation of the use of electrostrictive silicone polymers as actuators for mesoscale devices. The generated strains of both flat and rolled actuators, based on Dow Corning Sylgard 182 and 184, with sputtered gold electrodes, are presented as functions of the applied electric field. Variables examined in this study include silicone film thickness, gold electrode thickness, cycling of the applied electric field, and actuator configuration (flat or rolled). In general, thinner silicone films and gold electrodes yielded greater strains, at a constant applied field. The actuator performance tended to deteriorate with repeated application of the electric field, and the gold electrodes cracked after being subjected to a large percentage strain.Nomenclature A Cross sectional area, mm² - a ₁ , a ₂ electrostrictive constants, m²/V² - D diameter, mm - E electric field, V/m - _o permittivity of free space, F/m - dielectric constant for silicones, F/m - F force, N - J work, J - l length, m - S _ij strain tensor, dimensionless - S _ijkl tensor of elastic compliance coefficients, m - t thickness, m - T _kl stress tensor, Pa - u _i displacement vector, mm - V volume, mm³ - Poisson ratio, dimensionless - w width, m - Y Youngs modulus, Pa     

Micromechanical digital-to-analog converter for out-of-plane motion

This paper describes a novel micromechanical digital-to-analog converter (MDAC) for out-of-plane motion using electrostatic parallel-plate actuators. The proposed mechanism converts an N-bit digital signal to a mechanical out-of-plane displacement that is proportional to the analog value represented by the N-bit binary word. The mechanism is analogous to that of an electrical binary-weighted-input digital-to-analog converter (DAC). It consists of a movable platform, an array of parallel-plate microactuators each operating in an ON/OFF mode and a set of connection springs that connect the actuators to the platform. The spring constants of the connection springs are weighted so that the stiffness of successive springs is related by a factor of 2. A 4-bit mechanism has been fabricated using the Poly-MUMPS process, achieving a total stroke of 675 nm (full-scale output) and step size (LSB) of 45 nm in a highly repeatable and stable manner. The linearity error (LE) of the device is within /spl plusmn/0.28 LSB, and the differential linearity error (DLE) is within /spl plusmn/0.25 LSB. This mechanism can be configured for many promising applications, particularly in optical devices and systems such as tunable external cavity diode laser, tunable VCSELs, adaptive micromirror array and tunable wavelength filter.     

Differential Cytotoxicity of Curcumin-Loaded Micelles on Human Tumor and Stromal Cells

Although curcumin in the form of nanoparticles has been demonstrated as a potential anti-tumor compound, the impact of curcumin and nanocurcumin in vitro on normal cells and in vivo in animal models is largely unknown. This study evaluated the toxicity of curcumin-loaded micelles in vitro and in vivo on several tumor cell lines, primary stromal cells, and zebrafish embryos. Breast tumor cell line (MCF7) and stromal cells (human umbilical cord vein endothelial cells, human fibroblasts, and human umbilical cord-derived mesenchymal stem cells) were used in this study. A zebrafish embryotoxicity (FET) assay was conducted following the Organisation for Economic Co-operation and Development (OECD) Test 236. Compared to free curcumin, curcumin PM showed higher cytotoxicity to MCF7 cells in both monolayer culture and multicellular tumor spheroids. The curcumin-loaded micelles efficiently penetrated the MCF7 spheroids and induced apoptosis. The nanocurcumin reduced the viability and disturbed the function of stromal cells by suppressing cell migration and tube formation. The micelles demonstrated toxicity to the development of zebrafish embryos. Curcumin-loaded micelles demonstrated toxicity to both tumor and normal primary stromal cells and zebrafish embryos, indicating that the use of nanocurcumin in cancer treatment should be carefully investigated and controlled.     

Individual Variabilities in Adipose Stem Cell Proliferation,Gene Expression and Responses to Lipopolysaccharide Stimulation

Adipose stem cells (ASCs) are reported to play a role in normal physiology as well as in inflammation and disease. The objective of this work was to elucidate inter-individual differences in growth, gene expression and response to inflammatory stimuli in ASCs from different donors. Human ASC1 (male donor) and ASC2 (female donor) were purchased from Lonza (Walkersville, MD). Cell proliferation was determined by the sulforhodamine B assay. After time-dependent treatment of ASCs with or without bacterial lipopolysaccharide (LPS), marker gene mRNAs for proliferation, steroid hormones, and xenobiotic and immune pathways were determined using RT-PCR, and secreted cytokine levels in media were measured using the Bio-Plex cytokine assay kit. ASCs from both donors expressed androgen receptors but not estrogen receptors. ASC2 had a 2-fold higher proliferation rate and a 6-fold higher level of proliferation marker Ki67 mRNA than ASC1. ASC2 exhibited significantly greater fold induction of TNF-α and CCL2 by LPS compared to ASC1. TNF-α and GM-CSF protein levels were also significantly higher in the LPS-induced ASC2 media, but IL-6 secretion was higher in the LPS-induced ASC1 media. Our findings suggest that inter-individual variability and/or possible sex differences exist in ASCs, which may serve as a key determinant to inflammatory responses of ASCs.     

Lactobacillus sakei MJM60958 as a Potential Probiotic Alleviated Non-Alcoholic Fatty Liver Disease in Mice Fed a High-Fat Diet by Modulating Lipid Metabolism,Inflammation, and Gut Microbiota

Non-alcoholic fatty liver disease (NAFLD) is a common liver disease with a rapidly increasing number of cases worldwide. This study aimed to evaluate the effects of Lactobacillus sakei MJM60958 (MJM60958) on NAFLD in vitro and in vivo. In in vitro tests, MJM60958 significantly inhibited lipid accumulation by 46.79% in HepG2 cells stimulated with oleic acid and cholesterol (OA-C). Moreover, MJM60958 showed safe and probiotic characteristics in vitro. In the animal study, MJM60958 administration in a high-fat diet-induced NAFLD mouse model significantly reduced body weight and liver weight, and controlled aspartate aminotransferase (ALT), aspartate transaminase (AST), triglyceride (TG), urea nitrogen (BUN), and uric acid (UA) levels in the blood, which are features of NAFLD. Further, treatment with MJM60958 also reduced steatosis scores in liver tissues, serum leptin and interleukin, and increased serum adiponectin content. Moreover, administration of MJM60958 resulted in a significantly decreased expression of some genes and proteins which are related to lipid accumulation, such as fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC), and sterol regulatory element-binding protein 1 (SREBP-1), and also upregulated genes and protein expression of lipid oxidation such as peroxisome proliferator-activated receptor alpha (PPARα) and carnitine palmitoyltransferase 1a (CPT1A). Administration of MJM60958 increased the relative abundance of specific microbial taxa such as Verrucomicrobia, which are abundant in non-NAFLD mice, and reduced Firmicutes, which are a major group in NAFLD mice. MJM60958 affected the modulation of gut microbiota and altered the strain profile of short-chain fatty acids (SCFAs) production in the cecum by reduced lactic acid and enhanced acetic acid production. Overall, MJM60958 showed potential as a probiotic that can prevent and treat NAFLD.     

Applying Wide & Deep Learning Model for Android Malware Classification

Android malware has exploded in popularity in recent years, due to the platform’s dominance of the mobile market. With the advancement of deep learning technology, numerous deep learning-based works have been proposed for the classification of Android malware. Deep learning technology is designed to handle a large amount of raw and continuous data, such as image content data. However, it is incompatible with discrete features, i.e., features gathered from multiple sources. Furthermore, if the feature set is already well-extracted and sparsely distributed, this technology is less effective than traditional machine learning. On the other hand, a wide learning model can expand the feature set to enhance the classification accuracy. To maximize the benefits of both methods, this study proposes combining the components of deep learning based on multi-branch CNNs (Convolutional Network Neural) with wide learning method. The feature set is evaluated and dynamically partitioned according to its meaning and generalizability to subsets when used as input to the model’s wide or deep component. The proposed model, partition, and feature set quality are all evaluated using the K-fold cross validation method on a composite dataset with three types of features: API, permission, and raw image. The accuracy with Wide and Deep CNN (WDCNN) model is 98.64%, improved by 1.38% compared to RNN (Recurrent Neural Network) model.     

Comparison of modified injection molding and conventional machining in biodegradable behavior of perforated cannulated magnesium hip stents

In this study,perforated cannulated magnesium(Mg)hip stents were fabricated via modified Mg injection molding and conventional machining,respectively.Additionally,the stent canal was filled with paraffin to simulate injection of biomaterials.The microstructure,mechanical performance,corrosion behavior,and biocompatibility were comparably studied.Scanning electron microscopy(SEM)and energy dispersive spectroscopy(EDS)showed higher affinity of interstitial element such as oxygen and carbon as consequences of routine molding process.After immersion in SBF,machining stents showed reduced degradation rate and increased deposition of calcium phosphate compared to molding stents.Corrosion resistance was improved via paraffin-filling.Consistently,the hemolysis and in vitro osteoblast cell culture models showed favourable biocompatibility in machining stents compared to molding ones,which was improved by paraffin-filling treatment as well.These results implied that the feasibility of the prepared machining stents as the potential in vivo orthopaedic application where slower degradation is required,which could be enhanced by designing canal-filling injection of biomaterials as well.     

Open dumping site in Asian developing countries: a potential source of polychlorinated dibenz-p-dioxins and polychlorinated dibenzofurans

Open landfill dumping areas for municipal wastes in Asian developing countries have recently received particular attention with regard to environmental pollution problems. Because of the uncontrolled burning of solid wastes, elevated contamination by various toxic chemicals including dioxins and related compounds in these dumping sites has been anticipated. In this study, concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and coplanar polychlorinated biphenyls (PCBs) were determined in soils from dumping sites in the Philippines, Cambodia, India, and Vietnam. Residue concentrations of PCDD/Fs and coplanar PCBs in dumping site soils were apparently greater than those in soils collected in agricultural or urban areas far from dumping sites, suggesting that dumping sites are potential sources of PCDD/Fs and related compounds. Observed PCDD/F concentrations in soils from dumping sites in the Philippines and Cambodia were comparable or higher than those reported for dioxin-contaminated locations in the world (e.g., near the municipal waste incinerators and open landfill dumping sites). Homologue profiles of PCDD/Fs in dumping site soils from the Philippines and, to a lesser extent, from Cambodia and India reflected patterns of samples representing typical emissions, while profiles of agricultural or urban soils were similar to those of typical environmental sinks. This result suggests recent formation of PCDD/Fs in dumping site areas and that open dumping sites are a potential source of dioxins in Asian developing countries. Uncontrolled combustions of solid wastes by waste pickers, generation of methane gas, and low-temperature burning can be major factors for the formation of dioxins in dumping sites. Elevated fluxes of PCDD/Fs to soils in dumping sites were encountered in the Philippines, Cambodia, India, and Vietnam-Hanoi, and these levels were higher than those reported for other countries. Considerable loading rates of PCDD/Fs in the dumping sites of these countries were observed, ranging from 20 to 3900 mg/yr (0.12-35 mg TEQ/yr). PCDD/F concentrations in some soil samples from the Philippines, Cambodia, India, and Vietnam-Hanoi exceeded environmental guideline values, suggesting potential health effects on humans and wildlife living near these dumping sites. The estimated intakes of dioxins via soil ingestion and dermal exposure for children were higher than those for adults, suggesting greater risk of dioxin exposure for children in dumping sites. To our knowledge, this is the first comprehensive study on PCDD/Fs contamination in open dumping sites of Asian developing countries. On the basis of the result of this study, we have addressed a new environmental issue that open dumping sites are potential sources of PCDD/Fs and related compounds, and dioxin contamination in dumping sites may become a key environmental problem in developing countries.