Optimization on the Crosswind Stability of Trains Using Neural Network Surrogate Model

Under the influence of crosswinds,the running safety of trains will decrease sharply,so it is necessary to optimize the suspension parameters of trains.This paper studies the dynamic performance of high-speed trains under cross-wind conditions,and optimizes the running safety of train.A computational fluid dynamics simulation was used to determine the aerodynamic loads and moments experienced by a train.A series of dynamic models of a train,with different dynamic parameters were constructed,and analyzed,with safety metrics for these being determined.Finally,a surrogate model was built and an optimization algorithm was used upon this surrogate model,to find the mini-mum possible values for:derailment coefficient,vertical wheel-rail contact force,wheel load reduction ratio,wheel lateral force and overturning coefficient.There were 9 design variables,all associated with the dynamic parameters of the bogie.When the train was running with the speed of 350 km/h,under a crosswind speed of 15 m/s,the bench-mark dynamic model performed poorly.The derailment coefficient was 1.31.The vertical wheel-rail contact force was 133.30 kN.The wheel load reduction rate was 0.643.The wheel lateral force was 85.67 kN,and the overturning coef-ficient was 0.425.After optimization,under the same running conditions,the metrics of the train were 0.268,100.44 kN,0.474,34.36 kN,and 0.421,respectively.This paper show that by combining train aerodynamics,vehicle system dynamics and many-objective optimization theory,a train's stability can be more comprehensively analyzed,with more safety metrics being considered.     

On the Capacity of Cluster-Based Cooperative MIMO Cellular System with Universal or Fractional Frequency Reuse

The information-theoretic capacity for the cluster-based multicell cooperative processing (MCP) network with inter-cluster interference is investigated in this paper. An upper bound for the ergodic capacity is derived by the QR decomposition of the channel matrix, which is concisely expressed and close to the results from numerical simulations. Capacity results for the universal frequency reuse (UFR) network show that the cluster-based MCP system has great advantages over the non-cooperated system, and the capacity gain depends mainly on the size of the cooperative cluster, the radius of the cell and the path loss exponent (PLE). However, the cluster-based UFR system is still interference limited, whose capacity declines sharply due to the inter-cluster interference. Therefore, a cluster-based fractional frequency reuse (FFR) network is proposed to improve the system capacity, simulation results show that the cluster-based FFR system can outperform the UFR system, especially for the cases of small radius of cell or small PLE.     

无熟料水泥混凝土耐酸及耐海水性能研究

无熟料水泥混凝土是利用水淬高炉矿渣和激发剂在常温下经配料、研磨而成的新型水泥来配制的混凝土,其耐酸及耐海水性能不但取决于水淬高炉矿渣的碱度、化学成分和玻璃化率,而且还取决于激发剂的种类和数量.基于此,以废石膏和石灰作为激发剂配制无熟料水泥混凝土(简称NSC)后,进行了耐酸性能和耐海水性能的实验分析.结果表明,其耐酸、耐海水性能远优于普通水泥混凝土.     

基于高阶累积量矩阵组正交联合对角化的高分辨方位估计方法

该文提出了一种基于高阶累积量矩阵组正交联合对角化的高分辨方位估计方法。该方法构造了一组高阶累积量矩阵共同来辨识阵列流型矩阵的列空间,进而进行DOA估计。并通过对高阶累积量矩阵组进行联合对角化,得到联合对角化矩阵和对角化后的矩阵组,并重新定义了空间谱。新方法可以处理相干声源,适用于有色噪声环境,且较仅使用单个高阶累积量矩阵的算法具有更高的分辨力,更低的均方根误差和更高的鲁棒性。     

贵州秋季栽培不同荞麦品种成熟期果实中黄曲霉及其毒素的分离与鉴定

本研究以贵阳秋季栽培的2个米苦荞(F.tataricum,贵米苦荞18-1号和贵黑米苦荞12号)、2个多苦荞(F.tatari-cymosum,贵多苦荞003C和贵多苦荞60)、2个甜荞(F.esculentum,贵红花甜荞2号和1412-1)、2个常规苦荞(F.tataricum,定苦荞1号和六苦2017)为材料。对其成熟期种子果壳和籽粒进行了黄曲霉分离鉴定,并采用高效液相色谱法对所有品种果壳和籽粒中分离出的黄曲霉菌株进行AFB₁、AFB₂、AFG₁和AFG₂毒素的检测。结果表明,所有品种果壳中均没有分离出黄曲霉菌落;4类荞麦籽粒中仅米苦荞分离出了黄曲霉菌落,共分离出4株黄曲霉菌株。其中贵米苦荞18-1号黄曲霉带菌率为1.56%,贵黑米苦荞12号黄曲霉带菌率为0.78%。分离菌株形态学和ITS序列扩增产物测序结果与已知黄曲霉菌序列完全一致。毒素检测结果表明不同品种之间产毒素差异显著,所有品种籽粒中只有米苦荞中检出4种毒素,贵米苦荞18-1号产AFB₁最高为(5.861±0.055) μg/kg、AFB₂最少为(1.605±0.052) μg/kg,贵黑米苦荞12号产AFB₁最高为(14.475±0.533) μg/kg、AFG₂最少为(3.393±0.151) μg/kg;籽粒产毒量远大于分离菌株产毒量;各分离出菌株之间产毒素能力差异显著,最大产AFT为(11.102±0.095) μg/kg、最小产AFT为(1.794±0.024) μg/kg。上述结果显示供试米苦荞籽粒带菌来源可能是由于果壳开裂籽粒外露后部分籽粒被直接侵染所致。所得结果可为米苦荞中黄曲霉抗性育种研究及荞麦种子的保存、运输、储藏等研究奠定基础。     

车载视频下改进的核相关滤波跟踪算法

针对相关滤波跟踪算法在车载视频下由于环境复杂及目标尺度变化等情况下容易跟踪失败的问题,该文提出一种基于背景信息的尺度自适应相关滤波跟踪算法。首先利用背景感知相关滤波跟踪器融合方向梯度直方图特征预测目标下一帧位置,然后根据预测位置选取图像块进行检测,最后结合动态尺度比例金字塔模型对目标进行尺度估计。实验选取了KITTI数据库中23段车载视频和标注国内的4段车载视频进行测试,实验结果表明,该算法能有效降低车载环境的复杂背景、目标尺度变化等因素干扰,整体性能优于KCF, DSST, SAMF, SATPLE等主流相关滤波算法,对车载环境下复杂背景和尺度变化的目标跟踪具有鲁棒性。     

考虑寄生电感的谐振开关电容变换器电压尖峰抑制

基于碳化硅(SiC)器件的谐振开关电容变换器(RSCC)因其软开关特性,适用于高频、高功率密度的场合.但是较高的工作频率使其对线路寄生参数较敏感,易造成开关器件的电压尖峰问题.通过分析RSCC叠层母排模型,该文建立含有寄生电感的等效电路,研究寄生电感对电路运行模态的影响,并推导开关器件电压峰值与寄生电感之间的关系.在此...     

SHMT2 Induces Stemness and Progression of Head and Neck Cancer

Various enzymes in the one-carbon metabolic pathway are closely related to the development of tumors, and they can all be potential targets for cancer therapy. Serine hydroxymethyltransferase2 (SHMT2), a key metabolic enzyme, is very important for the proliferation and growth of cancer cells. However, the function and mechanism of SHMT2 in head and neck cancer (HNC) are not clear. An analysis of The Cancer Genome Atlas (TCGA) data showed that the expression of SHMT2 was higher in tumor tissue than in normal tissue, and its expression was significantly associated with male sex, aggressive histological grade, lymph node metastasis, distant metastasis, advanced TNM stage, and lymphovascular invasion in HNC. SHMT2 knockdown in FADU and SNU1041 cell lines significantly inhibited cell proliferation, colony formation, migration, and invasion. Additionally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses using TCGA data revealed that SHMT2 was closely related to cancer stem cell regulation and maintenance. Furthermore, we found that silencing SHMT2 inhibited the expression of stemness markers and tumor spheroid formation compared with a control group. On the contrary, stemness markers were significantly increased after SHMT2 overexpression in HEP-2 cells. Interestingly, we found that knocking down SHMT2 reduced the expression of genes related to the Notch and Wnt pathways. Finally, silencing SHMT2 significantly reduced tumor growth and decreased stemness markers in a xenograft model. Taken together, our study suggests that targeting SHMT2 may play an important role in inhibiting HNC progression.     

Functional Characterization of Ubiquitination Genes in the Interaction of Soybean—Heterodera glycines

Ubiquitination is a kind of post-translational modification of proteins that plays an important role in plant response to biotic and abiotic stress. The response of soybean GmPUB genes to soybean cyst nematode (SCN, Heterodera glycines) infection is largely unknown. In this study, quantitative real-time PCR (qRT-PCR) was performed to detect the relative expression of 49 GmPUB genes in susceptible cultivar William 82 and resistant cultivar Huipizhi after SCN inoculation. The results show that GmPUB genes responded to cyst nematode infection at 1 day post-inoculation (dpi), 5 dpi, 10 dpi and 15 dpi. The expression levels of GmPUB16A, GmPUB20A, GmCHIPA, GmPUB33A, GmPUB23A and GmPUB24A were dramatically changed during SCN infection. Furthermore, functional analysis of these GmPUB genes by overexpression and RNAi showed that GmPUB20A, GmPUB33A and GmPUB24A negatively regulated soybean resistance under SCN stress. The results from our present study provide insights into the complicated molecular mechanism of the interaction between soybean and SCN.     

Effects of Exosomes Derived from Adipose-Derived Mesenchymal Stem Cells on Pyroptosis and Regeneration of Injured Liver

Although accumulating evidence indicates that exosomes have a positive therapeutic effect on hepatic ischemia–reperfusion injury (HIRI), studies focusing on the alleviation of liver injury by exosomes derived from adipose-derived mesenchymal stem cells (ADSCs-Exo) based on the inhibition of cell pyroptosis have not yet been reported. Exosomes contain different kinds of biologically active substances such as proteins, lipids, mRNAs, miRNAs, and signaling molecules. These molecules are widely involved in cell–cell communication, cell signal transmission, proliferation, migration, and apoptosis. Therefore, we investigated the positive effects exerted by ADSCs-Exo after hepatic ischemia–reperfusion with partial resection injury in rats. In this study, we found that the post-operative tail vein injection of ADSCs-Exo could effectively inhibit the expression of pyroptosis-related factors such as NLRP3, ASC, caspase-1, and GSDMD-N, and promote the expression of regeneration-related factors such as Cyclin D1 and VEGF. Moreover, we found that the above cellular activities were associated with the NF-κB and Wnt/β-catenin signaling pathways. According to the results, ADSCs and ADSCs-Exo can reduce pyroptosis in the injured liver and promote the expression of those factors related to liver regeneration, while they can inhibit the NF-κB pathway and activate the Wnt/β-catenin pathway. However, although adipose-derived mesenchymal stem cell (ADSC) transplantation can reduce liver injury, it leads to a significant increase in the pyroptosis-related protein GSDMD-N expression. In conclusion, our study shows that ADSCs-Exo has unique advantages and significance as a cell-free therapy to replace stem cells and still has a broad research prospect in the clinical diagnosis and treatment of liver injuries.