高速列车车轮多边形对轴箱的影响分析

为分析高速列车轴箱端盖脱落的原因,建立了轴箱端盖的有限元模型,通过模态分析得到了580Hz的固有模态,并依据模态试验验证了模态分析结果。经过和线路试验数据对比发现该固有频率和20阶多边形的激励频率很接近,针对这一情况应用多体动力学软件建立了包含轴箱和端盖的车辆动力学模型并对轴箱端盖的振动特性进行分析。结果表明:端盖处的加速度要远远大于轴箱体上的加速度,结合频谱分析可以确定轴箱端盖处发生了共振,激烈的振动会使预紧力下降,当预紧力下降到2.5kN螺栓发生松动。上述结论与试验结果一致,并且根据测力螺栓的和端盖的试验数据可以发现随着螺栓预紧力的下降端盖的振动更加剧烈。本研究确定了引发高铁轴箱端盖掉落的根本原因,对于高铁车辆的安全运行有一定的指导借鉴意义。     

卫星通信地球站的集中监控系统

卫星地球站监控系统的主要任务是对卫星通信站设备进行监视和控制管理。随着计算机技术、网络技术和远程控制技术的发展,卫星通信地球站向一体化发展,它同时担负着卫星数据传输和卫星站管理监控的双重任务,尤其是对远端站的管理监控。本文总结了以往卫星地面站监控系统优缺点,详细分析了卫星通信地球站集中监控管理系统的工作原理,提出了一套完整的同时针对地球主站和远端站集中监控管理的规划设计和工作流程,并给出了使用效果,旨在为卫星地面站的监控设计和实现提供借鉴思路。     

磁性固体碱K2O/LDO-γ-Fe2O3催化甘油合成碳酸甘油酯

为了解决甘油合成碳酸甘油酯产率较低及反应完成后催化剂的回收问题,制备磁性水滑石LDH-Fe₃O₄,以KNO₃为活性组分前驱体对其改性制备磁性固体碱催化剂K₂O/LDO-γ-Fe₂O₃,对KNO₃的负载量进行考察,对K₂O/LDO-γ-Fe₂O₃进行X射线衍射、扫描电子显微镜、 CO₂程序升温脱附、BET及磁化强度表征,采用单因素试验对K₂O/LDO-γ-Fe₂O₃催化甘油酯交换合成碳酸甘油酯的工艺条件进行了优化,并对K₂O/LDO-γ-Fe₂O₃的重复使用性能进行了考察。结果表明：KNO₃负载提供了大量的碱性位点,有利于催化剂催化活性的提高,KNO₃的最佳负载量为10%(以L...     

Targeted proteomics of myofilament phosphorylation and other protein posttranslational modifications

Global cardiac myofilament protein phosphorylation levels, and their site-specific stoichiometry, are physiologically and clinically relevant for heart function. Unlike myofilament phosphorylation, other PTMs such as O-GlcNAcylation are just beginning to gain attention due to their potential physiological and clinical implications. This review will focus on what is currently known about cardiac troponin I phosphorylation, and on the potential physiological and clinical impact of targeted proteomics including new findings on cardiac troponin I sites and stoichiometry. We will then discuss the increasing recognition of other myofilament PTMs functional relevance and the potential of targeted MS approaches, particularly MRM, for accelerating their systematic characterization. In addition, we will broadly discuss the development and application of MRM to quantitatively assess site-specific PTMs. Finally, we will give an overview of expert's consensus on MRM methods design/validation and best practices to develop MRM assays intended to reach clinical application. The unique ability of MRM and similar methods to identify and quantify cardiac myofilament PTMs is likely to become central in answering important biological questions in the field of cardiac integrative physiology.     

Multiplex assays for biomarker research and clinical application: translational science coming of age

Over the last decade, translational science has come into the focus of academic medicine, and significant intellectual and financial efforts have been made to initiate a multitude of bench-to-bedside projects. The quest for suitable biomarkers that will significantly change clinical practice has become one of the biggest challenges in translational medicine. Quantitative measurement of proteins is a critical step in biomarker discovery. Assessing a large number of potential protein biomarkers in a statistically significant number of samples and controls still constitutes a major technical hurdle. Multiplexed analysis offers significant advantages regarding time, reagent cost, sample requirements and the amount of data that can be generated. The two contemporary approaches in multiplexed and quantitative biomarker validation, antibody-based immunoassays and MS-based multiple (or selected) reaction monitoring, are based on different assay principles and instrument requirements. Both approaches have their own advantages and disadvantages and therefore have complementary roles in the multi-staged biomarker verification and validation process. In this review, we discuss quantitative immunoassay and multiple reaction monitoring/selected reaction monitoring assay principles and development. We also discuss choosing an appropriate platform, judging the performance of assays, obtaining reliable, quantitative results for translational research and clinical applications in the biomarker field.     

中文WINDOWS下测量平差系统的研制

介绍中文ＷＩＮＤＯＷＳ下运行的测量平差系统．该系统能对各种网进行平差处理．     

Bronsted酸性双核离子液体催化大豆油合成生物柴油（英文）

合成一系列Bronsted酸性双核离子液体,采用~1H NMR、IR与TG/DTG等方法进行了表征分析,并研究了其在大豆油和甲醇酯交换合成生物柴油中的催化性能。结果表明,离子液体催化剂的酸强度与其催化活性正相关,其中[TMHDABS][HSO_4]催化剂的活性最高,催化合成生物柴油的收率达92%,该催化剂连续使用5次依然具有较高的催化活性。     

一种信息系统授权实现方法

提出了一种信息系统中用户权限管理方法，这种用户－岗位角色－功能权限管理模型，不仅使信息系统安全管理较真实地体现了系统应用部门实际的岗位职责，而且简化了信息系统中对用户授权管理。     

高速列车设备舱底板的振动特性研究

为了优化设备舱底板的振动疲劳特性,建立了刚柔耦合多体动力学模型,分析了在武广谱载荷谱的线路条件激励下,底板关键位置的振动和车速的关系。研究发现,车辆设备舱底板的振动总体趋势是随着速度的增加而增加,但是在250km/h的时候,纵向振动幅值会比300km/h的要大。根据动力学仿真结果提取出载荷的大小,进行了有限元强度分析,得到了底板的最大应力和开孔位置的最大应力。滚动台试验数据和仿真结果一致,验证了模型的正确性。最后对底板进行了优化,加厚设备舱底板的厚度。对比发现,优化后的整体最大应力由8.78 MPa减小到4.79MPa,开孔处的最大应力由1.65MPa减小到0.95MPa,底板的强度性能得到了大幅度提高。     

移动电话综合业务管理系统的关键技术研究

本文围绕移动电话综合业务管理系统的业务需求,着重讨论了应用软件体系结构的设计以及移动计费和业务管理系统中部分关键技术,其中包括多层结构的实现技术,ＣＢＤ和软件总线的应用,参数驱动的实现策略,重单检查处理方法,最后介绍了移动交换机电子工单处理系统的实现。