Neuroimaging Modalities in Alzheimer’s Disease: Diagnosis and Clinical Features

Alzheimer’s disease (AD) is a neurodegenerative disease causing progressive cognitive decline until eventual death. AD affects millions of individuals worldwide in the absence of effective treatment options, and its clinical causes are still uncertain. The onset of dementia symptoms indicates severe neurodegeneration has already taken place. Therefore, AD diagnosis at an early stage is essential as it results in more effective therapy to slow its progression. The current clinical diagnosis of AD relies on mental examinations and brain imaging to determine whether patients meet diagnostic criteria, and biomedical research focuses on finding associated biomarkers by using neuroimaging techniques. Multiple clinical brain imaging modalities emerged as potential techniques to study AD, showing a range of capacity in their preciseness to identify the disease. This review presents the advantages and limitations of brain imaging modalities for AD diagnosis and discusses their clinical value.     

Clients' assimilation of experiences of their therapists.

In this study, we examined how clients internalize their therapists, understanding this phenomenon through the lens of the assimilation model, a theory of psychological change. The assimilation model describes people as comprised of multiple voices, each voice being a representation of interrelated experiences organized around significant people or events. In this study, we interviewed five former psychotherapy clients and asked them to describe how they experienced, and continue to experience, their therapists internally. On the basis of these interviews, we extended the assimilation model by constructing an account of how clients’ experiences of their therapists are internalized. (PsycINFO Database Record (c) 2010 APA, all rights reserved)