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43.
Data from the Cancer Registry of Slovenia were used in a cohort study to determine whether the incidence of second primary cancers in patients with first primary breast cancer differs from the incidence expected in the general population. Special interest was given to long-term survivors. The expected numbers of second primary cancers were calculated by multiplying the number of appropriate person-years at risk by the corresponding age- and calendar-period-specific cancer incidence rates for women in Slovenia. The risk of a second primary cancer was expressed as the standardized incidence ratio (SIR). Of the 8,917 patients newly diagnosed in the period 1961-85 and followed-up to the end of 1994, 547 (6.2 percent) developed second primary cancers, whereas 410 (4.7 percent) were expected (SIR = 1.3, 95 percent confidence interval [CI] = 1.2-1.4). The risk was higher among younger patients. In long-term survivors, the risk was increased significantly for second primary cancer of the breast (SIR = 1.4, CI = 1.1-1.7), lung cancer (SIR = 1.6, CI = 1.1-2.3), melanoma (SIR = 2.7, CI = 1.5-4.4) and non-melanoma skin cancers(SIR = 2.0, CI = 1.6-2.4), corpus uteri cancer(SIR = 1.6, CI = 1.2-2.1), ovarian cancer(SIR = 2.3, CI = 1.7-3.0), and thyroid cancer (SIR = 2.5, CI = 1.2-4.6). Our results confirm the findings of several cohort studies carried out in Europe, the United States, and Japan, indicating that breast cancer patients should be monitored carefully for the occurrence of second primary cancers. 相似文献
44.
Kyeong Joong Kim Jong-Yeul Suh Moon Gi Kang Kyu Tae Park 《Electronics letters》1998,34(13):1302-1303
The boundary is approximated by a polygon which can be encoded with the smallest number of bits for maximum distortion. The temporal redundancy between two successive frames is efficiently removed with the proposed scheme, resulting in a lower bit rate than the conventional algorithms 相似文献
45.
A new method to predict the critical heat flux (CHF) is proposed, based on the fuzzy clustering and artificial neural network. The fuzzy clustering classifies the experimental CHF data into a few data clusters (data groups) according to the data characteristics. After classification of the experimental data, the characteristics of the resulting clusters are discussed with emphasis on the distribution of the experimental conditions and physical mechanism. The CHF data in each group are trained in an artificial neural network to predict the CHF. The artificial neural network adjusts the weight so as to minimize the prediction error within the corresponding cluster. Application of the proposed method to the KAIST CHF data bank shows good prediction capability of the CHF, better than other existing methods. 相似文献
46.
RD Robinson 《Canadian Metallurgical Quarterly》1993,4(2):70-76
The safety and pharmacokinetics of L-627, a new injectable carbapenem antibiotic, were evaluated in healthy volunteers. In single-dose studies, 20, 40, 80, 150, 300 and 600 mg of L-627 were administered by i.v. infusions over 1 hour. Plasma concentration-time profiles were well described with a two-compartment open model. The half-life of elimination from plasma was 1.3 +/- 0.8 (mean +/- SD) hour, and the Cmax and AUC paralleled the doses given. The mean urinary recovery of unchanged L-627 within the first 12 hours was 63.1 +/- 2.7% of the dose. In the multiple-dose studies, 300 mg of L-627 (i.v. over 1 hour) was administered every 12 hours, 11 times in total and 600 mg of L-627 was administered every 12 hours, 9 times in total. No discernible accumulation of the drug in plasma was observed. There were no subjective or objective abnormal findings definitely attributable to the drug except that one subject in one of the multiple-dose regimens (300 mg b.i.d.) showed only a slight elevation of transaminase value, although the elevated value promptly recovered after completion of dosing. No abnormality was observed in the other multiple-dose regimen (600 mg b.i.d.). From these results, L-627 was concluded to be safe and well tolerated. 相似文献
47.
48.
The purpose of this work is to study the effects of specularly reflecting wall under the combined radiative and laminar free
convective heat transfer in an infinite square duct. An absorbing and emitting gray medium is enclosed by the opaque and diffusely
emitting walls. The walls may reflect diffusely or specularly. Boussinesq approximation is used for the buoyancy term. The
radiative heat transfer is evaluated using the direct discrete ordinates method. The parameters under considerations are Rayleigh
number, conduction to radiation parameter, optical thickness, wall emissivity and reflection mode. The differences caused
by the reflection mode on the stream line, and temperature distribution and wall heat fluxes are studied. Some differences
are observed for the categories mentioned above if the order of the conduction to radiation parameter is less than order of
10-3 for the range of Rayleigh number studied. The differences at the side wall heat flux distributions are observed as long as
the medium is optically thin. As the top wall emissivity decreases, the differences between these two modes are increased.
As the optical thickness decreases at the fixed wall emissivity, the differences also increase. The difference of the streamlines
or the temperature contours is not as distinct as the side wall heat flux distributions. The specular reflection may alter
the fluid motion. 相似文献
49.
This paper deals with the pricing and investment decision problem of multi-modal transportation systems in which the congestion
is a significant factor in the assessment of system costs. This study approaches this congestion pricing problem with a number
of social welfare maximization problems, all of which have the identical structure except financial constraints. One welfare
maximization problem examined in this study yields the pricing and investment decision, which can attain the first-best social
optimality for multi-modal transportation systems. Other welfare maximization problems show he second-best optimal solutions
that can address two policy questions in transportation economics, namely, the cross-subsidy between competing modes and peak-period
congestion charges on a single highway link.
Received: February 2001/Accepted: December 2001
This work was supported in part by funds from BK21 Research Division of Seoul National University for Social Infrastructure
and Construction Technology. 相似文献
50.
Biomechanical finite element analysis of bone cemented hip crack initiation according to stem design
Byeongsoo Kim Byungyoung Moon Junghong Park 《Journal of Mechanical Science and Technology》2006,20(12):2168-2177
The purpose of this investigation was to determine the specific fracture mechanics response of cracks that initiate at the
stem-cement interface and propagate into the cement mantle. Two-dimensional finite element models of idealized stem-cement-bone
cross-sections from the proximal femur were developed for this study. Two general stem types were considered; Rectangular
shape and Charnley type stem designs. The FE results showed that the highest principal stress in the cement mantle for each
case occurred in the upper left and lower right regions adjacent to the stem-cement interface. There was also a general decrease
in maximum tensile stress with increasing cement mantle thickness for both Rectangular and Charnley-type stem designs. The
cement thickness is found to be one of the important fatigue failure parameters which affect the longevity of cemented femoral
components, in which the thinner cement was significantly associated with early mechanical failure for shot-time period. 相似文献