Extended-spectrum beta-lactamase-producing Klebsiella pneumoniae strains causing nosocomial outbreaks of infection in the United Kingdom

Representative isolates from 10 distinct extended-spectrum beta-lactamase-producing strains of Klebsiella pneumoniae that caused hospital outbreaks in the United Kingdom from 1991 to 1994 were examined for relationships between their enzymes and plasmids. The beta-lactamases were identified by a combination of isoelectric focusing and gene sequencing. SHV-2 beta-lactamase was produced by isolates from four outbreaks, SHV-5 was involved in three, and SHV-4, TEM-15, and TEM-26 were involved in one outbreak each. All of the extended-spectrum beta-lactamases were encoded by self-transmissible plasmids, with sizes ranging from about 70 to 160 kb. No similarities between the restriction digest patterns of the extended-spectrum beta-lactamase-encoding plasmids were detected, except to some extent between those that produced TEM-15 and TEM-26. Thus, outbreaks of hospital infection with these organisms in the United Kingdom from 1991 to 1994 involved distinct organisms and resistance plasmids and appeared to be unrelated.     

Synthesis and triplex forming properties of an acyclic N7-glycosylated guanine nucleoside

A chiral acyclic nucleoside, one in which the ribose carbohydrate has been replaced with a glycerol-based linker, is prepared by glycosylating guanine at the N7-nitrogen. The stereochemically pure derivative is converted to a DMT-protected phosphoramidite for incorporation into DNA sequences. Sequence containing the acyclic N7-dG nucleoside are capable of forming DNA triplexes in which it is likely that the N1-H and N2-amino groups of the N7-dG are involved in recognition of the guanine base in G-C base pairs.     

控制棒钴吸收体的活度分布

应用单组中子微扰理论,对辐照后控制棒钴吸收体内活度分布进行理论分析,得到活度分布计算的解析表达式。对高通量工程试验堆(HFETR)首次出堆的2根控制棒钴吸收体进行数值计算。利用钴靶活度水下测量装置进行这2根钴吸收体活度分布的实验测量。计算与实验测量结果相符。通过理论计算所得到的活度分布可作为辐照后~(60)Co同位素分装依据。本文得到的控制棒相对价值曲线理论计算值与实验测量结果符合良好。     

气体动压轴承动态参数测定原理

将气体动压轴压简化为转化气膜系统后，针对其动力特点，给出气膜在微幅振动下动压轴承的实用数学模型和测定动态参数的方法，并进行了测量误差的修正。     

Stability analysis for discrete linear systems with state saturation by a saturation-dependent Lyapunov functional

This paper concerns the stability analysis problem of discrete linear systems with state saturation using a saturation-dependent Lyapunov functional.We introduce a free matrix characterized by the sum of the absolute value of each elements for each row less than 1,which makes the state with saturation constraint reside in a convex polyhedron.A saturation-dependent Lyapunov functional is then designed to obtain a sufficient condition for such systems to be globally asymptotically stable.Based on this stability criterion,the state feedback control law synthesis problem is also studied.The obtained results are formulated in terms of bilinear matrix inequalities that can be solved by the presented iterative linear matrix inequality algorithm.Two numerical examples are used to demonstrate the effectiveness of the proposed method.     

Adaptive fuzzy decentralized control for nonlinear large-scale systems based on high-gain observer

An adaptive fuzzy decentralized backstepping output-feedback control approach is proposed for a class of nonlinear large-scale systems with completely unknown functions,the interconnections mismatched in control inputs,and without the measurements of the states.Fuzzy logic systems are employed to approximate the unknown nonlinear functions,and an adaptive high-gain observer is developed to estimate the unmeasured states.Using the designed high-gain observer,and combining the fuzzy adaptive control theory with backstepping approach,an adaptive fuzzy decentralized backstepping output-feedback control scheme is developed.It is proved that the proposed control approach can guarantee that all the signals of the closed-loop system are semi-globally uniformly ultimately bounded(SUUB),and that the observer errors and the tracking errors converge to a small neighborhood of the origin by appropriate choice of the design parameters.Finally,a simulation example is provided to show the eectiveness of the proposed approach.     

石化行业自动化控制仪表常见故障分析及其处理

介绍化工生产过程中仪表故障及其处理措施。