Anticoagulation with low molecular weight heparin (Fragmin) during continuous hemodialysis in the intensive care unit

A preparation of low molecular weight heparin (Fragmin) was administered to patients with multiorgan failure receiving continuous venovenous hemodialysis. Three patients received a high-dose regimen (35 IU/kg bolus followed by 13 IU/kg infusion), and 7 received a low-dose regimen (8 and 5 IU/kg, respectively) for 36 h. High-dose Fragmin was associated with minimal clotting in the extracorporeal circuit. Plasma fibrinopeptide A levels declined, and mean anti-Xa activity was in the range 0.47-0.79 IU/ml. The urea equilibration coefficient (UEC) (100% at initiation) remained above 90% throughout. All 3 patients had mild bleeding episodes, which led to discontinuation of Fragmin in 1. During all low-dose treatments, marked thrombus formation occurred in the extracorporeal circuit, and in 2, the circuit clotted within the study period. Fibrinopeptide A levels further increased in 4 patients, and mean anti-Xa activity was in the range 0.27-0.53 IU/ml. UEC declined appreciably in 3 treatments (including the 2 in which early circuit clotting occurred). One patient experienced a mild bleeding episode. The low-dose Fragmin regimen produced safer anticoagulation in patients at risk from bleeding and is suitable for prolonged renal support although the tendency to thrombosis may necessitate more frequent circuit changes.     

面向多媒体特定应用的剖析和标注相结合MPSoC性能评估方法（英文）

研究目的:性能估计已成为异构MPSo C设计中一个非常重要且具有挑战性的任务。在设计早期进行准确快速估计性能对于设计空间探索十分必要。本文采用GCC剖析技术和代码标注技术,结合MPSo C分层抽象概念,探讨逐层次完善的性能评估技术在MPSo C体系结构探索中的应用。创新要点:为面向多媒体应用的MPSo C性能估计提出一个从VA层到TA层的剖析和标注相结合流程,使性能估计可以被有效逐层完善。研究方法:基于GNU gcov工具,在本机模拟过程中剖析给定应用程序代码执行的统计信息,并且支持实时性能分析,快速、准确估计VA模型的计算负载。基于VA模型得到的计算负载性能的结果标注,利用TA模型的System C时序精确级仿真得到通信延时结果,使TA模型性能估计更高效,完善整个MPSo C性能估计。重要结论:研究一个剖析和标注技术相结合的MPSo C性能评估方法和流程。在VA层得到准确计算负载性能并标注给TA层;在TA层利用基于标注的仿真方法完善通信延时,使得性能估计更高效。通过M-JPEG和MEPG2两个典型视频多媒体应用实验,展示本文方法的高效、快速与准确。     

Analysis of the p16 gene, CDKN2, in 17 Australian melanoma kindreds

CDKN2 has been implicated as a melanoma susceptibility gene in some kindreds with a family history of this disease. Mutation analysis of CDKN2 in 17 familial melanoma Australian kindreds revealed a paucity of exon mutations and none of the previously described disease-related mutations. One novel germline mutation was found in exon one, Arg24Pro, which segregates with melanoma in 1/17 kindreds. Two previously described polymorphisms, Ala148Thr and a base change at nucleotide 540 were detected and one novel polymorphism in the untranslated region of exon 3 (nucleotide 580) was also found. Together with other recent reports, these findings provide support for CDKN2 as a susceptibility locus for familial melanoma but suggest that other loci are involved in some hereditary melanoma kindreds.     

Endoscopic repair of traumatic CSF rhinorrhea in a pediatric patient

In performing cancer chemotherapy, it is essential to know the expression of multidrug resistant (MDR) P glycoprotein (p-gp) on cancer cells. In the present study, in order to clarify the relationship between MDR of leukemic cells and cytologic, immunological and clinical features of acute nonlymphocytic leukemia (ANLL), leukemic cells in peripheral blood and/or bone marrows obtained from 28 ANLL patients were examined. Each smear was stained with C219 monoclonal antibody against P-gp by the APAAP method, and then 1,000 ANLL cells in each smear were observed. Among the FAB subtypes, M4 showed the highest proportion of leukemic cells expressing P-gp. Concerning the response to chemotherapy, five of seven patients (71%) having 1.0% or more of P-gp positive leukemic cells and 11 of 19 patients (58%) having less than 1.0% of those cells achieved complete remission. However, there was no significant correlation between P-gp expression and clinical outcome. There was also no significant correlation between P-gp expression and CD7 or CD34. Furthermore, no significant correlation between chromosome 7 abnormality and P-gp expression was observed. From these results, if we can clarify the mechanism of MDR and the relationship between MDR and cytogenetic or clinical features of ANLL with further study, P-gp expression may become a useful marker for predicting the outcome of ANLL.