The cortisol response to psychological stress in temporomandibular dysfunction

Recombinant antibody fragments can be produced in large quantities using bacterial expression systems and could potentially be useful for the generation of biofilters for the selective removal of viral particles from fluids. A human single chain-Fv antibody library, derived from synthetic repertoires of germ line VH-gene segments rearranged in vitro and paired to a single light chain (Nissim et al., 1994, EMBO J., 13, 692-698), has recently been used to isolate hundreds of different binding specificities by panning with antigen. Antibodies from this library typically have affinities in the 10(6)-10(7) M-1 range. Occasionally, better binders are isolated but at other times the affinities recovered are poor. In the latter situation binding cannot be detected with soluble antibodies, but only by high-avidity display of multiple copies of antibodies on phage. By panning with human cytomegalovirus (HCMV)-coated immunotubes, we have isolated a number of antibody clones from this library that bound to the antigen only if displayed on the filamentous phage, but not in soluble form. One of these clones was selected for an affinity maturation procedure, achieved by combinatorial mutagenesis of the complementarity determining region 3 (CDR3) of the antibody light chain, followed by selection of the resulting library for HCMV binding. By this means, we were able to isolate a number of binders, some of which exhibited specific HCMV binding in soluble form. The clone that gave the strongest ELISA signal was expressed in bacteria, purified in solution, characterised using a novel capture methodology with surface plasmon resonance detection on a BIAcore instrument and used for the production of an immunofilter for the removal of HCMV form human serum. The filter removed more than 99% of applied HCMV in 10 min circulation time, while the amount of HCMV retained non-specifically in a cartridge derivatised with a non-specific antibody was less than 10% under similar conditions.     

Estimating Basic Characteristics of Arrival Processes in Telecommunication Networks by Empirical Data

Considering the realistic teletraffic analysis in advanced telecommunication networks, the estimation of basic characteristics of arrival processes by empirical data is an important subject of current research. Using independent observations of the interarrival times between events and the mean numbers of events in intervals of fixed length, we propose methods to estimate the intensity of a nonhomogeneous arrival stream, particularly a Poisson process, and the renewal function of a renewal process. We formulate the estimation task as stochastically ill-posed problem and apply procedures for the stabilization of the estimates.     

空间级联可调谐光滤波器方式实现光分插复用器

提出一种采用空间级联可调谐光滤波器方式实现的OADM.该器件不但具有集成度高、体积小、插入损耗低、信道间插入损耗差异小的特点,而且能够在控制电路的作用下灵活选择上下路波长及其数量,为构建灵活、高性能的WDM网络提供了选择.     

Design of a novel MRI compatible manipulator for image guided prostate interventions

This paper reports a novel remotely actuated manipulator for access to prostate tissue under magnetic resonance imaging guidance (APT-MRI) device, designed for use in a standard high-field MRI scanner. The device provides three-dimensional MRI guided needle placement with millimeter accuracy under physician control. Procedures enabled by this device include MRI guided needle biopsy, fiducial marker placements, and therapy delivery. Its compact size allows for use in both standard cylindrical and open configuration MRI scanners. Preliminary in vivo canine experiments and first clinical trials are reported.     

Multidimensional Waveform Encoding: A New Digital Beamforming Technique for Synthetic Aperture Radar Remote Sensing

This paper introduces the innovative concept of multidimensional waveform encoding for spaceborne synthetic aperture radar (SAR). The combination of this technique with digital beamforming on receive enables a new generation of SAR systems with improved performance and flexible imaging capabilities. Examples are high-resolution wide-swath radar imaging with compact antennas, enhanced sensitivity for applications like alongtrack interferometry and moving object indication, and the implementation of hybrid SAR imaging modes that are well suited to satisfy hitherto incompatible user requirements. Implementation-specific issues are discussed and performance examples demonstrate the potential of the new technique for different remote sensing applications.     

使用BUS端口保护阵列实现有源ESD保护

许多便携式应用需要超过8kV的ESD保护,同时将电容保持在5pF以下。Z二极管能够单独满足这一要求,但当与开关或结型二极管等低电容PN二极管相结合时,它们可同时满足该应用的以下两种要求:低电容,以及高ESD和     

Bistatic TerraSAR-X/F-SAR Spaceborne–Airborne SAR Experiment: Description, Data Processing, and Results

We report about the first X-band spaceborne–airborne bistatic synthetic aperture radar (SAR) experiment, conducted early November 2007, using the German satellite TerraSAR-X as transmitter and the German Aerospace Center's (DLR) new airborne radar system F-SAR as receiver. The importance of the experiment resides in both its pioneering character and its potential to serve as a test bed for the validation of nonstationary bistatic acquisitions, novel calibration and synchronization algorithms, and advanced imaging techniques. Due to the independent operation of the transmitter and receiver, an accurate synchronization procedure was needed during processing to make high-resolution imaging feasible. Precise phase-preserving bistatic focusing can only be achieved if time and phase synchronization exist. The synchronization approach, based on the evaluation of the range histories of several reference targets, was verified through a separate analysis of the range and Doppler contributions. After successful synchronization, nonstationary focusing was performed using a bistatic backprojection algorithm. During the campaign, stand-alone TerraSAR-X monostatic as well as interoperated TerraSAR-X/F-SAR bistatic data sets were recorded. As expected, the bistatic image shows a space-variant behavior in spatial resolution and in signal-to-noise ratio. Due to the selected configuration, the bistatic image outperforms its monostatic counterpart in almost the complete imaged scene. A detailed comparison between monostatic and bistatic images is given, illustrating the complementarity of both measurements in terms of backscatter and Doppler information. The results are of fundamental importance for the development of future nonsynchronized bistatic SAR systems.