Hyperthermia following MDMA administration in rats: effects of ambient temperature, water consumption, and chronic dosing

In two experiments it was found that the hyperthermia which follows MDMA ("Ecstasy") results from an interaction of direct pharmacological effect of the drug and the prevailing environmental conditions in which it is administered. In Experiment 1, rats given fixed doses of either 2.5, 5.0 or 7.5 mg/kg MDMA or saline were injected on different days at ambient temperatures (Ta's) of 11, 24, and 30 degrees C. At each Ta drinking water was freely available following dosing on one session and temporarily unavailable on a second. The hyperthermic and hyperkinetic responses were monitored using remote biotelemetry. Experiment 2 used a between-subject design in which each group of rats received a standard 7.5 mg/kg dose of MDMA administered at only one of the three levels of Ta(24 degrees C) and at only one level of the water-availability factor. Dosing in some groups was continued for a further 13 days to test for tolerance or sensitization effects. Ambient temperature significantly affected the magnitude of the hyperthermia but not the hyperkinesis. Water deprivation during the drugged period significantly augmented the hyperthermia, but only in the high Ta (30 degrees C.) condition. Chronic dosing produced sensitization of both hyperthermic and hyperkinetic responses. The findings indicate that ambient temperature, water consumption and frequency of drug use affect the hyperthermia which follows MDMA administration.     

Further studies on the influence of genotype and dietary protein on the performance of broilers

An experiment was conducted to quantify genetic differences in response to dietary protein level of male vs female broilers. Broilers (1 d old) from a "high-yield" strain cross (Ross x Ross 208) and a "fast-growing" strain cross (Peterson x Arbor Acres) were placed on fresh pine shavings in floor pens. From Day 0 to 18, all birds were fed a 23% CP starter diet. During Days 18 to 53 male birds were fed either a 16, 18, 20, 22, 24, or 26% CP diet (3,200 kcal ME/kg) and female birds were fed the 16, 20, or 24% CP diet. Significant differences (P < 0.05) were noted in the performance of the different strains. Ross x Ross 208 male birds had a higher body weight (3.37 vs 3.16 kg), higher feed intake (7.08 vs 6.78 kg), higher breast yield (31.76 vs 29.25%), higher carcass yield (73.90 vs 71.85%), and a lower adjusted feed conversion ratio (FCR; 2.10 vs 2.16 g:g) than Peterson x Arbor Acres males at 53 d of age. As compared to Peterson x Arbor Acres females, Ross x Ross 208 female broilers also had a higher body weight (2.68 vs 2.55 kg), higher breast meat yield (33.61 vs 30.80%), higher carcass yield (75.31 vs 73.91%), and lower adjusted FCR (1.97 vs 2.04 g:g). Qualitative differences in the response of these strains were confirmed and better qualitative data is presented that can be used to predict the important output parameters from the import inputs in broiler production.     

Early assessment of diaphragmatic dysfunction in children in the ITU: chest radiology and phrenic nerve stimulation

Diaphragmatic dysfunction is a common postoperative complication of cardiac surgery in children, with important effects on respiratory morbidity. Its early diagnosis, followed by prompt surgical intervention, has been shown to reduce morbidity. However, the commonest method of diagnosis, based on hemi-diaphragmatic elevation on the chest radiograph, may be less accurate than direct techniques for assessing phrenic nerve function. We have compared electrophysiological and radiological diagnoses of diaphragmatic abnormality in 100 children (aged 3 days to 17.5 yrs) undergoing cardiac surgery, looking at respiratory morbidity as assessed by the duration of ventilation, the time spent on the cardiac intensive care unit (CICU), and the requirement for reintubation. Despite showing good reproducibility, radiological diagnosis was neither sensitive nor specific in identifying patients with electrophysiological phrenic nerve damage. Analysis of the measures of outcome supported the electrophysiological technique. Patients with electrophysiological evidence of damage had a longer duration of ventilation, spent longer on the CICU, and had a greater incidence of reintubation than either radiologically abnormal or "normal" patients. Chest X-rays are not a good method for diagnosing phrenic nerve damage in the early postoperative period in children. If early diagnosis is needed, then direct assessment of phrenic nerve function, such as the measurement of phrenic latency, may be a better technique.     

The emergence of distributed component platforms

Several vendors and consortia have independently developed standards that define the basic mechanics for building and interconnecting software components. Sun's JavaBeans has emerged as the leading rival to Microsoft's DCOM, supplanting the OpenDoc standard from the now defunct Component Integration Laboratories. Component software is moving from its original focus on desktop-bound compound documents to enterprise applications that include distributed server components. The backers of competing standards are racing to capture market leadership by delivering the tangible benefits of component standards via distributed component platforms-integrated development and runtime environments that isolate much of the conceptual and technical complexity involved in building component-based applications. With DCPs, businesses can assign their few highly skilled programmers to component construction and use less sophisticated developers to carry out the simpler assembly tasks. By making component standards available to the broadest possible spectrum of developers, DCPs essentially drive those standards to market. This article reviews the state of component software as embodied in DCPs. The two DCP market leaders are Microsoft's DCOM (or ActiveX/DCOM) and Sun's JavaBeans. However, Internet and OMG component standards are emerging that will likely impact both the content and status of these two DCPs. The article also discusses component frameworks, which extend DCPs to provide more complete application development solutions     

Arduino-based slider setup for gas–liquid mass transfer investigations: Experiments and CFD simulations

The implementation of traditional sensors is a drawback when investigating mass transfer phenomena within microstructured devices, since they disturb the flow and reactor characteristics. An Arduino based slider setup is developed, which is equipped with a computer-vision system to track gas–liquid slug flow. This setup is combined with an optical analytical method allowing to compare experimental results against CFD simulations and investigate the entire lifetime of a single liquid slug with high spatial and temporal resolution. Volumetric mass transfer coefficients are measured and compared with data from literature and the mass transfer contribution of the liquid film is discussed.     

Universitärer Forschungscluster „Sustainable Technologies in Metal Production and Processing” (STMP)

Foundation of a university research cluster — Co-operation along the value creation chain from raw materials to components — Evidence of joint performance offers — Utilization of synergies — Integration of Christian Doppler Laboratories — Flexible arrangement of co-operations and networks     

多关节测量臂的小生境混沌优化校准

多关节测量臂是一种便携式的坐标测量设备,它由一系列的旋转关节组成。为了提高多关节测量臂的测量精度和可重复性水平,必须对其运动学参数进行校准。首先,利用小生境的混沌优化算法提出了一种新的运动学校准方法以及一种混合目标的运动学校准函数,它考虑了诸如单点测量实验、容积性测量实验等多种性能测量实验的实验结果,然后,采用Levenberg Marquardt(L-M)算法和小生境混沌优化算法应用于运动学参数校准。小生境混沌优化算法显示出了优于L-M算法的性能。实验结果表明:使用NCOA算法校准后,测量误差的标准差始终优于LMA算法,并且校准前后多关节测量臂的测量精度提高了40倍。采用L-M算法和小生境混沌优化算法应用于运动学参数校准。小生境混沌优化算法显示出了优于L-M算法的性能。