全文获取类型
收费全文 | 6067篇 |
免费 | 55篇 |
国内免费 | 2篇 |
专业分类
电工技术 | 13篇 |
综合类 | 6篇 |
化学工业 | 289篇 |
金属工艺 | 73篇 |
机械仪表 | 24篇 |
建筑科学 | 68篇 |
矿业工程 | 5篇 |
能源动力 | 47篇 |
轻工业 | 211篇 |
水利工程 | 13篇 |
无线电 | 189篇 |
一般工业技术 | 248篇 |
冶金工业 | 4726篇 |
原子能技术 | 17篇 |
自动化技术 | 195篇 |
出版年
2021年 | 27篇 |
2020年 | 15篇 |
2019年 | 21篇 |
2018年 | 35篇 |
2017年 | 37篇 |
2016年 | 47篇 |
2015年 | 20篇 |
2014年 | 34篇 |
2013年 | 76篇 |
2012年 | 49篇 |
2011年 | 82篇 |
2010年 | 62篇 |
2009年 | 54篇 |
2008年 | 75篇 |
2007年 | 80篇 |
2006年 | 69篇 |
2005年 | 57篇 |
2004年 | 55篇 |
2003年 | 51篇 |
2002年 | 44篇 |
2001年 | 49篇 |
2000年 | 31篇 |
1999年 | 152篇 |
1998年 | 1349篇 |
1997年 | 844篇 |
1996年 | 514篇 |
1995年 | 304篇 |
1994年 | 246篇 |
1993年 | 298篇 |
1992年 | 58篇 |
1991年 | 58篇 |
1990年 | 74篇 |
1989年 | 71篇 |
1988年 | 93篇 |
1987年 | 74篇 |
1986年 | 61篇 |
1985年 | 68篇 |
1984年 | 23篇 |
1983年 | 32篇 |
1982年 | 41篇 |
1981年 | 38篇 |
1980年 | 58篇 |
1979年 | 11篇 |
1978年 | 18篇 |
1977年 | 135篇 |
1976年 | 266篇 |
1975年 | 37篇 |
1974年 | 15篇 |
1973年 | 13篇 |
1972年 | 15篇 |
排序方式: 共有6124条查询结果,搜索用时 0 毫秒
81.
OBJECTIVE: To identify possible causes for the increased cardiovascular morbidity and mortality seen in patients with primary hyperparathyroidism. DESIGN: Prospective, blind study. SETTING: University hospital, Sweden. SUBJECTS: 44 Patients with primary hyperparathyroidism and 23 (sex and age matched) control patients with atoxic nodular goitres. INTERVENTIONS: Exploration of the neck with removal of pathological parathyroid glands or thyroid resection. Echocardiography before, and one year after, the operation. MAIN OUTCOME MEASURES: Blood pressure and echocardiographic findings. RESULTS: Hyperparathyroid patients had higher blood pressure and greater left atrial diameter than control patients preoperatively. They also had a significantly lower E:A ratio (mitral flow velocity pattern) than the controls (p = 0.02) indicating a disturbance in early diastolic filling of the left ventricle. The E:A ratio correlated negatively with the systolic blood pressure. 19 of the hyperparathyroid patients (43%) had cardiac calcifications as did 14 (61%) of the controls. Most of calcifications were located in the aortic and mitral valves; only a few patients had calcifications in the myocardium. No significant changes had occurred one year after parathyroidectomy, except for a reduction in systolic blood pressure, in the hyperparathyroid patients. CONCLUSION: Echocardiographic investigation of patients with primary hyperparathyroidism shows early signs of left ventricular dysfunction that may be of clinical importance. 相似文献
82.
83.
RM Hendry CV Hanson V Bongertz M Morgado A Duarte J Casseb L Brigido E Sabino R Diaz B Galv?o-Castro 《Canadian Metallurgical Quarterly》1996,91(3):347-348
The influence of noncompetitive (MK-801), competitive (AP-7) and the antagonist of polyamines site of NMDA receptor (arcaine) on the central activity of angiotensin II (A II) was studied. The open field test, conditioning of active avoidance responses (CARs) and passive avoidance situation was used to investigate learning and memory in rats. All used antagonists decreased beneficial action of A II on these processes. 相似文献
84.
RM Summers J Andrasko-Bourgeois IM Feuerstein SC Hill EC Jones MK Busse B Wise KE Bove BA Rishforth E Tucker TL Spray JM Hoeg 《Canadian Metallurgical Quarterly》1998,98(6):509-518
Hepatitis C chronically infects approximately 1.5% of Americans and is the most common clinical problem facing hepatologists. Since the virus was initially described in 1989, development of an effective therapy has been challenging. Although several different therapeutic agents have been used, no therapy has been shown to reliably eradicate the virus. Interferon-alpha, a cytokine with immunostimulatory and anti-viral properties, has become the therapy of choice for patients with chronic hepatitis C infection. Trials assessing the efficacy of interferon-alpha have characterized host and viral factors predictive of responses to treatment. A thorough understanding of these predictive factors is requisite to providing cost-effective therapeutic decisions for the patient with chronic hepatitis C infection. 相似文献
85.
This paper describes a fixed-weight Hamming binary neural classifier chip suitable for applications where high-speed operation is required. The circuit uses switched current-mode techniques throughout and achieves classification in one forward pass through the network. The chip was realized in 2.4-μm n-well CMOS technology and was designed to recognize the integers 0-9. It achieved a classification rate of 10 MHz without any observable tendency to misclassification or instability 相似文献
86.
Previous studies have shown that Tetrahymena citrate synthase and the Tetrahymena 14-nm filament protein are encoded by a single gene and translated from one species of mRNA, and that they are identical in terms of molecular weight, antigenicity, and some enzymatic properties. In this study, using two-dimensional gel electrophoresis, we demonstrated that the citrate synthase comprised pI 7.7 and 8.0 isoforms, while the 14-nm filament protein comprised three isoforms with isoelectric points of 7.7, 8.0, and 8.4. The amino acid sequences of the NH2-terminal portions of all isoforms were identical and the peptide maps with V8 protease were almost the same. In addition, when the citrate synthase activity of each isoform was measured after separation by non-urea isoelectric focusing without denaturing treatment, the pI 7.7 and/or pI 8.0 isoforms exhibited the citrate synthase activity, but the pI 8.4 isoform only found for the 14-nm filament protein did not possess this activity. These results suggest that the polymorphism of these isoforms is caused by some posttranslational modifications, and that it may have resulted in the different compartmentalization and functions of Tetrahymena citrate synthase and the 14-nm filament protein. 相似文献
87.
88.
J Seoane K Trinh RM O'Doherty AM Gómez-Foix AJ Lange CB Newgard JJ Guinovart 《Canadian Metallurgical Quarterly》1997,272(43):26972-26977
Glucose-6-phosphatase (G6Pase) catalyzes the hydrolysis of glucose 6-phosphate (Glu-6-P) to free glucose and, as the last step in gluconeogenesis and glycogenolysis in liver, is thought to play an important role in glucose homeostasis. G6Pase activity appears to be conferred by a set of proteins localized to the endoplasmic reticulum, including a glucose-6-phosphate translocase, a G6Pase phosphohydrolase or catalytic subunit, and glucose and inorganic phosphate transporters in the endoplasmic reticulum membrane. In the current study, we used a recombinant adenovirus containing the cDNA encoding the G6Pase catalytic subunit (AdCMV-G6Pase) to evaluate the metabolic impact of overexpression of the enzyme in primary hepatocytes. We found that AdCMV-G6Pase-treated liver cells contain significantly less glycogen and Glu-6-P, but unchanged UDP-glucose levels, relative to control cells. Further, the glycogen synthase activity state was closely correlated with Glu-6-P levels over a wide range of glucose concentrations in both G6Pase-overexpressing and control cells. The reduction in glycogen synthesis in AdCMV-G6Pase-treated hepatocytes is therefore not a function of decreased substrate availability but rather occurs because of the regulatory effects of Glu-6-P on glycogen synthase activity. We also found that AdCMV-G6Pase-treated-cells had significantly lower rates of lactate production and [3-3H]glucose usage, coupled with enhanced rates of gluconeogenesis and Glu-6-P hydrolysis. We conclude that overexpression of the G6Pase catalytic subunit alone is sufficient to activate flux through the G6Pase system in liver cells. Further, hepatocytes treated with AdCMV-G6Pase exhibit a metabolic profile resembling that of liver cells from patients or animals with non-insulin-dependent diabetes mellitus, suggesting that dysregulation of the catalytic subunit of G6Pase could contribute to the etiology of the disease. 相似文献
89.
MD Medlock JR Madsen PD Barnes DS Anthony LE Cohen RM Scott 《Canadian Metallurgical Quarterly》1997,27(3):121-128
There are many in vivo animal models for studying airway mucus secretion and hypersecretion, each with advantages and disadvantages. Use of a particular test system will depend upon the aspect of secretion to be modelled. Airway hypersecretory diseases exhibit chronic mucus hypersecretion, of which the clinical impact is predominantly in the distal airways. The majority of documented test preparations study acute secretion, invariably using tracheal preparations, but have been invaluable in elucidating the normal physiology of airway mucus secretion. Chronic models of the hypersecretory state in the distal airways have been developed, but are predominantly histologic in nature (for example quantification of increased goblet cell number). There are few investigations of mucus hypersecretion. Examination of the 'antisecretory' potential of pharmaceutical compounds has been investigated predominantly in chronic histologic models with the drug being given 'prophylactically' rather than 'therapeutically'. Refinement of chronic hypersecretory models should lead to elucidation of the connection between airway irritation, inflammation, MUC gene expression, mucous cell hyperplasia/metaplasia, airway hypersecretion and bronchial hypersecretory disease. 相似文献
90.