Rheumatoid-like joint lesions in rabbits injected intravenously with bovine serum

Rheumatoid-like synovial lesions have been produced experimentally in 21% of rabbits receiving intravenous injections of bovine serum by various regimens. They were characterized by lining cell hyperplasia, accumulations, often follicular, of lymphocytes and plasma cells just under the lining layer, sometimes with extensive fibroplasia and pannus formation with cartilage erosion.     

Image processing with VLSI

The development and implementation of systems for the more complex realtime image processing and scene understanding tasks, such as robot vision and remote surveillance, calls for faster computation than that possible using the traditional serial computer. The advent of VLSI has made feasible the consideration of more specialized processing architectures, designed to support these datarates, while keeping systems compact and relatively cheap. Two approaches are discussed: the use of a programmable processor array, and the customizing of image processing algorithms in silicon. This paper examines designs based upon each approach in the light of the techniques and constraints of VLSI. In particular we describe in some detail an example of a VLSI parallel array processor, the Grid (GEC rectangular image and data processor), and a number of special-purpose CMOS/SOS chips based on systolic design techniques.     

ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer

Overexpression of the erbB-2 gene contributes to aggressive behavior of various human adenocarcinomas, including breast cancer, through an unknown molecular mechanism. The erbB-2-encoded protein is a member of the ErbB family of growth factor receptors, but no direct ligand of ErbB-2 has been reported. We show that in various cells ErbB-2 can form heterodimers with both EGF receptor (ErbB-1) and NDF receptors (ErbB-3 and ErbB-4), suggesting that it may affect the action of heterologous ligands without the involvement of a direct ErbB-2 ligand. This possibility was addressed in breast cancer cells through either overexpression of ErbB-2 or by blocking its delivery to the cell surface by means of an endoplasmic reticulum-trapped antibody. We report that ErbB-2 overexpression enhanced binding affinities to both EGF and NDF, through deceleration of ligand dissociation rates. Likewise, removal of ErbB-2 from the cell surface almost completely abolished ligand binding by accelerating dissociation of both growth factors. The kinetic effects resulted in enhancement and prolongation of the stimulation of two major cytoplasmic signaling pathways, namely: MAP kinase (ERK) and c-Jun kinase (SAPK), by either ligand. Our results imply that ErbB-2 is a pan-ErbB subunit of the high affinity heterodimeric receptors for NDF and EGF. Therefore, the oncogenic action of ErbB-2 in human cancers may be due to its ability to potentiate in trans growth factor signaling.