Reconsidering the sauce: A comment on Floyd.

Comments on the article Fundamentalism: Sauce for the goose by K. Floyd (see record 2007-09680-001). Floyd reminds us that the application of a little logic to the propositions we claim are true can sometimes show us that our beliefs are untenable, and that such a finding "could turn out to be very freeing indeed". In particular, he uses one of the arguments some of us struggled with the first time we met logic as a discipline: If P is true then Q is true. Q isn't true. Therefore, P isn't true. Floyd applies this principle to religious belief: If I believe that P is true and Q is true when in fact P implies that 0 is false then I am truly inconsistent! He also shows how easily we are willing to use such logic on the beliefs of others but not on our own beliefs. The current authors' attempt to demonstrate that Floyd makes several questionable steps in his reasoning, thereby calling into question the conclusions he draws. Floyd has sought to point out the lack of thought behind numerous religious beliefs. The current authors accept this general observation, but they believe it unfair to attribute this difficulty only to religious beliefs. The difficulty with religious beliefs is not that they are not concerned with truth vs. non-truth, but rather that for a number of reasons, the difference between these two poles is often not obvious. The question of the validity of religious beliefs is a philosophically spiny one that has been addressed, sometimes adequately and sometimes in very illogical, emotional and violent fashions, for thousands of years. It seems obvious to the authors that "three minutes thought" is not sufficient to untangle such an issue. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Model-based parameter estimation in electromagnetics. I. Backgroundand theoretical development

This article first provides a background and motivation for using model based parameter estimation (MBPE) in electromagnetics, focusing on the use of fitting models that are described by exponential and pole series. How data obtained from various kinds of sampling procedures can be used to quantify such models, i.e., to determine numerical values for their coefficients is also presented. The paper continues by illustrating applications of MBPE to various kinds of EM observables. It concludes by discussing how MBPE might be used to improve the efficiency of first-principles models based on frequency-domain integral equations     

Serologic survey of Toxoplasma gondii in grizzly bears (Ursus arctos) and black bears (Ursus americanus), from Alaska, 1988 to 1991

We tested 644 serum samples from 480 grizzly bears and 40 black bears from Alaska (USA), collected between 1988 and 1991, for Toxoplasma gondii antibodies, using a commercially available latex agglutination test (LAT). A titer > or = 64 was considered positive. Serum antibody prevalence for T. gondii in grizzly bears (Ursus arctos) was 18% (87 of 480). Prevalence ranged from 9% (seven of 77) on Kodiak Island to 28% (15 of 54) in northern Alaska. Prevalence was directly correlated to age. No grizzly bears < 2-year-old had T. gondii antibody. High antibody titers were found mainly in grizzly bears captured north of the Arctic Circle. Antibody prevalence in black bears (Ursus americanus) from Interior Alaska was 15% (six of 40), similar to the prevalence in grizzly bears from the same area (13%; five of 40).     

Evolutionary dynamics of genetic variation in Epstein-Barr virus isolates of diverse geographical origins: evidence for immune pressure-independent genetic drift

The question whether immune pressure exerted by cytotoxic T lymphocytes (CTLs) can influence the long-term evolution of genetically stable viruses such as Epstein-Barr virus (EBV) has generated considerable scientific interest, primarily due to its important implications for the overall biology of the virus. While arguing for a role of CTLs in the evolution of viruses, it is important to differentiate between genetic variation in virus and immune recognition of these variant virus by CTLs. To assess the role of genetic selection in the long-term evolution of EBV, we have analyzed a large panel of type 1 EBV isolates from African, Southeast Asian, Papua-New Guinean (PNG), and Australian Caucasian individuals. Seven different regions of the EBV genome, which include nine CTL epitopes restricted through a range of HLA class I alleles, were sequenced and compared. Although numerous nucleotide changes were identified within these isolates, comparison of synonymous and nonsynonymous substitutions in the CTL epitope indicated that the genetic variation was generated mostly independently of immune selection pressure. Surprisingly, an inverse correlation between genetic variation within certain CTL epitopes and the frequency distribution of HLA alleles that present the CTL epitopes was seen, suggesting that the evolutionary pressures on the CTL epitopes of the virus may be toward their conservation rather than their inactivation. Furthermore, molecular evolutionary genetic analysis of nucleotide sequences revealed that viral isolates from PNG are evolving as a lineage distinct from isolates from African, Southeast Asian, and Australian Caucasian individuals.