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11.
Mixed tocopherols (MT) containing a predominance of γ‐tocopherol were evaluated for antioxidant (AO) performance in polybutadiene‐ and polyisoprene‐based styrenic block copolymers (SBS and SIS, respectively) by using oxidative induction time as a measure of AO performance. A conventional hindered phenolic AO and α‐tocopherol (vitamin E) were evaluated in comparison. MT exhibited significantly higher performance than the controls in both SIS and SBS polymers. J. VINYL ADDIT. TECHNOL., 12:73–77, 2006. © 2006 Society of Plastics Engineers 相似文献
12.
Discusses the nature of autonomy and explores how autonomy as a therapeutic goal relates to clinical practice and the conduct of psychotherapy. Autonomy has been defined as the power to determine one's own best interests, and it has been criticized for promoting selfishness and reflecting upper-class values and gender bias. It is suggested that issues of autonomy are involved in the process of psychotherapy as well as its aim. In therapy, there is a dynamic tension between the principle of autonomy, the right of clients to determine their own interests, and the principle of beneficence, the therapist's obligation to protect the client's welfare. Whether autonomy is an appropriate ideal in psychotherapy for women or for men is considered. Feminist theorists have criticized aspects of masculine autonomy, contrasting it with feminine relatedness; however, the idealization of relatedness is questioned. It is concluded that the present conceptualizations of autonomy do not fully encompass the complexity of human interaction. It is argued that (a) autonomy and relatedness are not essential aspects of male and female nature but depend on power and status and (b) without social change, autonomy may not be a realistic goal of therapy for women. (46 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
13.
Nicholas Vishnosky Jasmine C. Gomez Spencer T. Kim Emma J. Doukmak Jeremy Grafstein Rachel C. Steinhardt 《大分子材料与工程》2021,306(9):2100222
Actuators made of soft matter are needed for a variety of fields ranging from biomedical devices to soft robotics to microelectromechanical systems. While there are a variety of excellent methods of soft actuation known, the field is still an area of intense research activity as new niches and needs emerge with new technology development. Here, a soft actuation system is described, based on a core-multi-shell particle, which moves via photothermal expansion. The system consists of a novel polystyrene-based thermally expandable microsphere, with a secondary shell of a silicate-silane graft copolymer, to which gold nanoparticles are covalently linked. The gold nanoparticles act as photothermal nano-transducers, converting light energy into the thermal energy necessary for microsphere expansion, which in turn results in material movement. Actuation is shown in isolated particles in thermal and photothermal regimes using metal ceramic heaters or 520 nm laser illumination, respectively. Macroscale actuation is demonstrated by making a composite material of particles suspended in the transparent elastomer polydimethylsiloxane. The sample demonstrates an inchworm-like movement by starting from an arched geometry. Overall, this work describes a new particle-based actuation method for soft materials, and demonstrates its utility in driving the movement of a composite elastomer. 相似文献
14.
Rodrigo F. Ortiz-Meoz Liping Wang Rosalie Matico Anna Rutkowska-Klute Martha De la Rosa Sabrina Bedard Robert Midgett Katrin Strohmer Douglas Thomson Cunyu Zhang Makda Mebrahtu Jeffrey Guss Rachel Totoritis Thomas Consler Nino Campobasso David Taylor Tia Lewis Kurt Weaver Marcel Muelbaier John Seal Richard Dunham Wieslaw Kazmierski David Favre Giovanna Bergamini Lisa Shewchuk Alan Rendina Guofeng Zhang 《Chembiochem : a European journal of chemical biology》2021,22(3):516-522
Indoleamine-2,3-dioxygenase 1 (IDO1) is a heme-containing enzyme that catalyzes the rate-limiting step in the kynurenine pathway of tryptophan (TRP) metabolism. As it is an inflammation-induced immunoregulatory enzyme, pharmacological inhibition of IDO1 activity is currently being pursued as a potential therapeutic tool for the treatment of cancer and other disease states. As such, a detailed understanding of the mechanism of action of IDO1 inhibitors with various mechanisms of inhibition is of great interest. Comparison of an apo-form-binding IDO1 inhibitor (GSK5628) to the heme-coordinating compound, epacadostat (Incyte), allows us to explore the details of the apo-binding inhibition of IDO1. Herein, we demonstrate that GSK5628 inhibits IDO1 by competing with heme for binding to a heme-free conformation of the enzyme (apo-IDO1), whereas epacadostat coordinates its binding with the iron atom of the IDO1 heme cofactor. Comparison of these two compounds in cellular systems reveals a long-lasting inhibitory effect of GSK5628, previously undescribed for other known IDO1 inhibitors. Detailed characterization of this apo-binding mechanism for IDO1 inhibition might help design superior inhibitors or could confer a unique competitive advantage over other IDO1 inhibitors vis-à-vis specificity and pharmacokinetic parameters. 相似文献
15.
Sun Shaojian; Brem Rachel; Chan Hue Sun; Dill Ken A. 《Protein engineering, design & selection : PEDS》1995,8(12):1205-1213
We present two methods for designing amino acid sequences ofproteins that will fold to have good hydrophobic cores. Giventhe coordinates of the desired target protein or polymer structure,the methods generate sequences of hydrophobic (H) and polar(P) monomers that are intended to fold to these structures.One method designs hydrophobic inside, polar outside; the otherminimizes an energy function in a sequence evolution process.The sequences generated by these methods agree at the levelof 6080% of the sequence positions in 20 proteins inthe Protein Data Bank. A major challenge in protein design isto create sequences that can fold uniquely, i.e. to a singleconformation rather than to many. While an earlier lattice-basedsequence evolution method was shown not to design unique folders,our method generates unique folders in lattice model tests.These methods may also be useful in designing other types offoldable polymer not based on amino acids 相似文献
16.
17.
Maret G. Traber Seth R. Diamond Jerome C. Lane Rachel I. Brody Herbert J. Kayden 《Lipids》1994,29(10):665-669
The purpose of this study was to investigate the temporal relationships of the transport of β-carotene in human lipoproteins.
We administered 60 mg β-carotene with breakfast to nine fasting subjects, then blood samples were collected at intervals of
up to 75 h, lipoproteins were isolated, and β-carotene was quantitated. β-Carotene concentrations in chylomicrons and very
low density lipoproteins (VLDL) peaked at 6 and 9 h, respectively. Nonetheless, at all time points the majority of plasma
β-carotene was contained in low density lipoproteins (LDL), while high density lipoproteins (HDL) carried a smaller portion
(at 24 h, 73±8% in LDL as compared with 23±5% in HDL). In three subjects, transport of β-carotene was compred with the results
of earlier studies on the transport of stereoisomers of α-tocopherol. Unlike plasmaRRR-α-tocopherol concentrations, which are maintained by the preferential incorporation ofRRR-α-tocopherol into VLDL by the liver, β-carotene increased and decreased in VLDL similarly toSRR-α-tocopherol, a stereoisomer whose concentrations are not maintained in plasma. In conclusion, β-carotene is primarily transported
in the plasma in LDL, but its incorporation by the liver into lipoproteins does not appear to be enhanced. 相似文献
18.
The H2/NO/O2 reaction under lean-burn conditions has been studied by means of in situ DRIFTS, reactor measurements and temperature-programmed desorption with the aim of understanding the very different behavior of Pd/TiO2 and Pd/Al2O3 catalysts. The former deliver very high NO
x
conversions (70-80%) with good N2 selectivity whereas the latter show very low activity. In addition, PdTiO2 exhibits two distinct NO
x
reduction pathways, thus greatly extending the useful temperature range. It is shown that the PdTiO2 low-temperature channel involves adsorption and subsequent dissociation of NO on reduced (Pd0) metal sites. The low activity of PdAl2O3 is a consequence of palladium remaining in an oxidized state under reaction conditions. The high-temperature NO reduction channel found with PdTiO2 is associated with the generation and subsequent reaction of NH
x
species. 相似文献
19.
在许多情况下,只应用一种NDT技术存在不足,这就迫使NDT操作人员使用一种以上的技术以保证检测出危害被检物使用寿命或功能的缺陷。但分别实施多种技术的检测,就会延长检验时间。介绍了一种新的NDT设施,采用两种不同的非接触无损检测技术进行互补,即电磁声换能器(EMAT)和脉冲涡流(PEC)探头。检测结果表明,脉冲涡流和电磁声换能器因是非接触,所以可应用于材料生产过程中的自动在线检验,也可用于在役检验。 相似文献
20.
Driving a Wedge Between Evidence and Beliefs: How Online Ideological News Exposure Promotes Political Misperceptions 下载免费PDF全文
R. Kelly Garrett Brian E. Weeks Rachel L. Neo 《Journal of Computer-Mediated Communication》2016,21(5):331-348
This article has 2 goals: to provide additional evidence that exposure to ideological online news media contributes to political misperceptions, and to test 3 forms this media‐effect might take. Analyses are based on representative survey data collected during the 2012 U.S. presidential election (N = 1,004). Panel data offer persuasive evidence that biased news site use promotes inaccurate beliefs, while cross‐sectional data provide insight into the nature of these effects. There is no evidence that exposure to ideological media reduces awareness of politically unfavorable evidence, though in some circumstances biased media do promote misunderstandings of it. The strongest and most consistent influence of ideological media exposure is to encourage inaccurate beliefs regardless of what consumers know of the evidence. 相似文献