SARS-CoV-2 Spike Protein Binding of Glycated Serum Albumin—Its Potential Role in the Pathogenesis of the COVID-19 Clinical Syndromes and Bias towards Individuals with Pre-Diabetes/Type 2 Diabetes and Metabolic Diseases

The immune response to SARS-CoV-2 infection requires antibody recognition of the spike protein. In a study designed to examine the molecular features of anti-spike and anti-nucleocapsid antibodies, patient plasma proteins binding to pre-fusion stabilised complete spike and nucleocapsid proteins were isolated and analysed by matrix-assisted laser desorption ionisation–time of flight (MALDI-ToF) mass spectrometry. Amongst the immunoglobulins, a high affinity for human serum albumin was evident in the anti-spike preparations. Careful mass comparison revealed the preferential capture of advanced glycation end product (AGE) forms of glycated human serum albumin by the pre-fusion spike protein. The ability of bacteria and viruses to surround themselves with serum proteins is a recognised immune evasion and pathogenic process. The preference of SARS-CoV-2 for AGE forms of glycated serum albumin may in part explain the severity and pathology of acute respiratory distress and the bias towards the elderly and those with (pre)diabetic and atherosclerotic/metabolic disease.     

Review and comparative evaluation of symbolic dynamic filtering for detection of anomaly patterns

Symbolic dynamic filtering (SDF) has been recently reported in literature as a pattern recognition tool for early detection of anomalies (i.e., deviations from the nominal behavior) in complex dynamical systems. This paper presents a review of SDF and its performance evaluation relative to other classes of pattern recognition tools, such as Bayesian Filters and Artificial Neural Networks, from the perspectives of: (i) anomaly detection capability, (ii) decision making for failure mitigation and (iii) computational efficiency. The evaluation is based on analysis of time series data generated from a nonlinear active electronic system. This work has been supported in part by the U.S. Army Research Laboratory and the U.S. Army Research Office under Grant No. W911NF-07-1-0376, by the U.S. Office of Naval Research under Grant No. N00014-08-1-380, and by NASA under Cooperative Agreement No. NNX07AK49A.     

聚合物波导电光调制器

尽管直接调制激光二级管控制光波是一种简单是一种简单且重要的调制方式，但光波导结构的调制器将使器件性能得到惊人的改善，本文简略介绍了聚合物波导电光调制器，并给出了制备该器件的聚合物材料及制备过程。     

Moisture Sensitive Smart Yarns and Textiles from Self‐Balanced Silk Fiber Muscles

Smart textiles that sense, interact, and adapt to environmental stimuli have provided exciting new opportunities for a variety of applications. However, current advances have largely remained at the research stage due to the high cost, complexity of manufacturing, and uncomfortableness of environment‐sensitive materials. In contrast, natural textile materials are more attractive for smart textiles due to their merits in terms of low cost and comfortability. Here, water fog and humidity‐driven torsional and tensile actuation of thermally set twisted, coiled, plied silk fibers, and weave textiles from these silk fibers are reported. When exposed to water fog, the torsional silk fiber provides a fully reversible torsional stroke of 547° mm^?1. Coiled‐and‐thermoset silk yarns provide a 70% contraction when the relative humidity is changed from 20% to 80%. Such an excellent actuation behavior originates from water absorption‐induced loss of hydrogen bonds within the silk proteins and the associated structural transformation, which are corroborated by atomistic and macroscopic characterization of silk and molecular dynamics simulations. With its large abundance, cost‐effectiveness, and comfortability for wearing, the silk muscles will open up additional possibilities in industrial applications, such as smart textiles and soft robotics.     

Optimal security hardening on attack tree models of networks: a cost-benefit analysis

Researchers have previously looked into the problem of determining whether a given set of security hardening measures can effectively make a networked system secure. However, system administrators are often faced with a more challenging problem since they have to work within a fixed budget which may be less than the minimum cost of system hardening. An attacker, on the other hand, explores alternative attack scenarios to inflict the maximum damage possible when the security controls are in place, very often rendering the optimality of the controls invalid. In this work, we develop a systematic approach to perform a cost-benefit analysis on the problem of optimal security hardening under such conditions. Using evolutionary paradigms such as multi-objective optimization and competitive co-evolution, we model the attacker-defender interaction as an “arms race”, and explore how security controls can be placed in a network to induce a maximum return on investment.     

Coupled acoustic-shell model for experimental study of cell stiffness under acoustophoresis

Under the influence of acoustic radiation force, particles can be trapped and deformed at the pressure node in a microfluidic channel. Based on this principle, the elastic modulus of biological cells can be estimated. In this study, a numerical framework, consisting of a boundary element model for acoustic field and an axisymmetric shell model, is developed to simulate the cell deformation under acoustic radiation force. The boundary element model is used to calculate the radiation traction exerted on the cell surface. The cell membrane deformation due to this traction is simulated by using the axisymmetric shell model. The Young’s moduli of algae and red blood cell membranes are then estimated by comparing the experimental observation with the simulated membrane deformation. It is found that the value of Young’s modulus of the red blood cell membrane is lower than that of algae cell membrane. Furthermore, for both cells, the estimated Young’s moduli are negligible compared to the bulk moduli of the cells reported in the previous studies.     

Recent Books

This unique and interesting book covers technical aspects of antenna noise temperature for large antennas, such as those of NASA's Deep Space system, encountered during the author's 40+ year career there. It is a true engineering book that gets right down to details and does not entertain tutorials, so is not a quick read. However, it is well referenced: most of the references are available via the Internet, from JPL's Web pages, and IEEExplore, if needed. The work described covers the frequencies from 2 to 32 GHz, with few excursions outside this range.     

Comparative studies of the effect of moderate and high altitude stress on human subjects: studies on erythrocyte ghost ATPases

Studies have been carried out on erythrocyte membrane‐bound ATPases of ten female subjects at a moderate altitude (2200 m) and at a high altitude (5100 m). Mg²⁺‐ATPase activity of the subjects was found to be significantly stimulated under conditions at a high altitude in comparison to that at a moderate altitude. The changes in total lipids and cholesterol contents of erythrocyte ghosts and plasma Na⁺/K⁺ levels at high altitude in comparison to the moderate altitude indicates an alteration in the membrane permeability under high altitude stress. On acclimatization of the subjects from a high to a moderate altitude, the studied parameters reverted to the values as observed at a moderate altitude.