A Stress and Coping Model of Medication Adherence and Viral Load in HIV-Positive Men and Women on Highly Active Antiretroviral Therapy (HAART).

The authors tested a structural model that incorporated age, time since diagnosis, social support, coping, and negative mood as predictors of medication adherence and HIV viral load on 188 men and 134 women on highly active antiretroviral therapy (HAART). The authors used psychosocial latent factors formed from baseline measures to predict latent factors of adherence, as assessed by electronic monitoring and self-report, and viral load defined by indicators assessed over a 15-month period. Results from the model indicate that greater negative mood and lower social support are related to greater use of avoidance-oriented coping strategies. Use of these coping strategies by patients on HAART is related to poorer medication adherence and, subsequently, higher viral load. This model advances researchers' understanding of the contribution of psychosocial variables in predicting treatment adherence and disease progression in HIV-positive men and women. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

An Experimental and Theoretical Comparison of Model Selection Methods

Machine Learning - We investigate the problem of model selection in the setting of supervised learning of boolean functions from independent random examples. More precisely, we compare methods for...     

Summative evaluation of the SINCGARS Tutor

In an earlier set of studies with a different Intelligently Coached Simulation (Orey, M.A., Fan, H., Park, J., Tzeng, S., & Gustafson, K. (1995). Evaluation of Device operator in a context of a coached simulation environment), we found a retention and a transfer problem. We tried to solve these problems while building a new Intelligently Coached Simulation (the SINCGARS Tutor). The solutions to the two problems were to use an interactive conceptual model for the retention problem and we used photographs of the equipment as the visuals of the simulation. We then tested this new tutor with a group of 22 officers who were not only required to know how to operate the SINCGARS radio, but would be responsible for teaching others in their unit when their training was complete. We had one group of officers train on the real equipment, in pairs, with one instructor available for guidance. The other group of 11 learned via the SINCGARS Tutor. The post test was to put an actual radio into operation while being observed by a trained observer. Results indicate that not only did the transfer problem go away, but officers trained on the computer performed the task more accurately both initially on the immediate post test and again on a surprise four-week delayed post test. The SINCGARS Tutor was found to be a very good training solution.     

Competitive analysis of incentive compatible on-line auctions

This paper studies auctions in a setting where the different bidders arrive at different times and the auction mechanism is required to make decisions about each bid as it is received. Such settings occur in computerized auctions of computational resources as well as in other settings. We call such auctions, on-line auctions.

We first characterize exactly on-line auctions that are incentive compatible, i.e. where rational bidders are always motivated to bid their true valuation. We then embark on a competitive worst-case analysis of incentive compatible on-line auctions. We obtain several results, the cleanest of which is an incentive compatible on-line auction for a large number of identical items. This auction has an optimal competitive ratio, both in terms of seller's revenue and in terms of the total social efficiency obtained.     

Lessons and Challenges from Mining Retail E-Commerce Data

The architecture of Blue Martini Software's e-commerce suite has supported data collection, data transformation, and data mining since its inception. With clickstreams being collected at the application-server layer, high-level events being logged, and data automatically transformed into a data warehouse using meta-data, common problems plaguing data mining using weblogs (e.g., sessionization and conflating multi-sourced data) were obviated, thus allowing us to concentrate on actual data mining goals. The paper briefly reviews the architecture and discusses many lessons learned over the last four years and the challenges that still need to be addressed. The lessons and challenges are presented across two dimensions: business-level vs. technical, and throughout the data mining lifecycle stages of data collection, data warehouse construction, business intelligence, and deployment. The lessons and challenges are also widely applicable to data mining domains outside retail e-commerce.     

TRADE‐OFF BETWEEN APPROXIMATION ACCURACY AND COMPLEXITY FOR TS FUZZY MODELS

This paper proposes a transformation method that serves the trade‐off between the modelling complexity and accuracy of multi‐variable Takagi‐Sugeno fuzzy inference operator‐based modelling (TS fuzzy modelling). The relation between the number of fuzzy rules and the modelling accuracy is defined in the paper. The proposed transformation method is capable of finding the minimal number of fuzzy rules for a given accuracy of a given TS fuzzy model. A case study, focusing on a benchmark problem of fault diagnosis, developed in the framework of EC‐founded Research Training Network DAMADICS, of an actuator in a sugar factory, is presented to provide feasibility of the proposed method.     

Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies

The thyroid gland of children is especially vulnerable to the carcinogenic action of ionizing radiation. To provide insights into various modifying influences on risk, seven major studies with organ doses to individual subjects were evaluated. Five cohort studies (atomic bomb survivors, children treated for tinea capitis, two studies of children irradiated for enlarged tonsils, and infants irradiated for an enlarged thymus gland) and two case-control studies (patients with cervical cancer and childhood cancer) were studied. The combined studies include almost 120,000 people (approximately 58,000 exposed to a wide range of doses and 61,000 nonexposed subjects), nearly 700 thyroid cancers and 3,000,000 person years of follow-up. For persons exposed to radiation before age 15 years, linearity best described the dose response, even down to 0.10 Gy. At the highest doses (> 10 Gy), associated with cancer therapy, there appeared to be a decrease or leveling of risk. For childhood exposures, the pooled excess relative risk per Gy (ERR/Gy) was 7.7 (95% CI = 2.1, 28.7) and the excess absolute risk per 10(4) PY Gy (EAR/10(4) PY Gy) was 4.4 (95% CI = 1.9, 10.1). The attributable risk percent (AR%) at 1 Gy was 88%. However, these summary estimates were affected strongly by age at exposure even within this limited age range. The ERR was greater (P = 0.07) for females than males, but the findings from the individual studies were not consistent. The EAR was higher among women, reflecting their higher rate of naturally occurring thyroid cancer. The distribution of ERR over time followed neither a simple multiplicative nor an additive pattern in relation to background occurrence. Only two cases were seen within 5 years of exposure. The ERR began to decline about 30 years after exposure but was still elevated at 40 years. Risk also decreased significantly with increasing age at exposure, with little risk apparent after age 20 years. Based on limited data, there was a suggestion that spreading dose over time (from a few days to > 1 year) may lower risk, possibly due to the opportunity for cellular repair mechanisms to operate. The thyroid gland in children has one of the highest risk coefficients of any organ and is the only tissue with convincing evidence for risk about 1.10 Gy.     

Speech separation using speaker-adapted eigenvoice speech models

We present a system for model-based source separation for use on single channel speech mixtures where the precise source characteristics are not known a priori. The sources are modeled using hidden Markov models (HMM) and separated using factorial HMM methods. Without prior speaker models for the sources in the mixture it is difficult to exactly resolve the individual sources because there is no way to determine which state corresponds to which source at any point in time. This is solved to a small extent by the temporal constraints provided by the Markov models, but permutations between sources remains a significant problem. We overcome this by adapting the models to match the sources in the mixture. We do this by representing the space of speaker variation with a parametric signal model-based on the eigenvoice technique for rapid speaker adaptation. We present an algorithm to infer the characteristics of the sources present in a mixture, allowing for significantly improved separation performance over that obtained using unadapted source models. The algorithm is evaluated on the task defined in the 2006 Speech Separation Challenge [Cooke, M.P., Lee, T.-W., 2008. The 2006 Speech Separation Challenge. Computer Speech and Language] and compared with separation using source-dependent models. Although performance is not as good as with speaker-dependent models, we show that the system based on model adaptation is able to generalize better to held out speakers.     

Phason dynamics in nonlinear photonic quasicrystals

We study the dynamics of phasons in a nonlinear photonic quasicrystal. The photonic quasicrystal is formed by optical induction, and its dynamics is initiated by allowing the light waves inducing the quasicrystal to nonlinearly interact with one another. We show quantitatively that, when phason strain is introduced in a controlled manner, it relaxes through the nonlinear interactions within the photonic quasicrystal. We establish experimentally that the relaxation rate of phason strain in the quasicrystal is substantially lower than the relaxation rate of phonon strain, as predicted for atomic quasicrystals. Finally, we monitor and identify individual 'atomic-scale' phason flips occurring in the photonic quasicrystal as its phason strain relaxes, as well as noise-induced phason fluctuations.