Asian-American cultural identity and attitudes toward mental health services.

557 Asian-American students (263 Chinese Americans, 185 Japanese Americans, and 109 Korean Americans) completed a survey consisting of a demographic questionnaire, a modified version of the Suinn-Lew Asia Self-Identity Acculturation Scale, and the Attitudes Toward Seeking Professional Psychological Help Scale (ATSPHS). A 3?×?2?×?2 multivariate analysis with main effects of ethnicity, gender, and level of acculturation and the 4 subscales of the ATSPHS as the dependent variables resulted in a significant F value for acculturation effect and nonsignificant F values for all other main and interaction effects. Regardless of ethnicity and gender, the most acculturated students were: (a) most likely to recognize personal need for professional psychological help, (b) most tolerant of the stigma associated with psychological help, and (c) most open to discussing their problems with a psychologist. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Schön warm zudecken ...

Fall und Kommentare

Sch?n warm zudecken ...     

Evaluation of elemental profile coupled to chemometrics to assess the geographical origin of Argentinean wines

Traceability of wines requires knowledge of their characteristics, which are associated with the geographical origin of grape, soil, water, climate as well as the winery techniques. The aim of this work was to classify wines and soil from three production areas of Argentina according to multielement data. The influence of the provenance soil on the wine element composition was also investigated.Eleven elements were determined in 31 wine samples and 137 soil samples from regions under study. Stepwise discriminant analysis allows us to correctly classify 100% of the wines analysed from the three regions using only seven parameters (K, Fe, Ca, Cr, Mg, Zn and Mn) and 92% correct classification for soils using seven variables (Ca, Cr, K, Fe, Cu, Zn and, Mg). Canonical analysis between soils and wines datasets affords a correlation coefficient of 0.85 (P-value < 0.001). Thus, almost 85% of variability observed amongst wines could be attributed to the soil in which the vines were cultivated.The analysis of elemental concentrations in the wines and soils, in combination with chemometrics, provides a powerful tool to verify the geographical origin of wines.     

Morphologic and functional changes in the unilateral 6-hydroxydopamine lesion rat model for Parkinson’s disease discerned with μSPECT and quantitative MRI

Object

In the present study, we aimed to evaluate the impact of neurodegeneration of the nigrostriatal tract in a rodent model of Parkinson’s disease on the different MR contrasts (T₂, T₁, CBF and CBV) measured in the striatum.

Material and methods

Animals were injected with 6-hydroxydopamine (6OHDA) in the substantia nigra resulting in massive loss of nigrostriatal neurons and hence dopamine depletion in the ipsilateral striatum. Using 7T MRI imaging, we have quantified T₂, T₁, CBF and CBV in the striata of 6OHDA and control rats. To validate the lesion size, behavioral testing, dopamine transporter μSPECT and tyrosine hydroxylase staining were performed.

Results

No significant differences were demonstrated in the absolute MRI values between 6OHDA animals and controls; however, 6OHDA animals showed significant striatal asymmetry for all MRI parameters in contrast to controls.

Conclusions

These PD-related asymmetry ratios might be the result of counteracting changes in both intact and affected striatum and allowed us to diagnose PD lesions. As lateralization is known to occur also in PD patients and might be expected in transgenic PD models as well, we propose that MR-derived asymmetry ratios in the striatum might be a useful tool for in vivo phenotyping of animal models of PD.     

Molecular dynamics simulations of the unfolding of {beta}2-microglobulin and its variants

In this study, we examined the unfolding processes of nativeß₂-microglobulin and two related variants, one withan N-terminal hexapeptide deletion