全文获取类型
收费全文 | 3951篇 |
免费 | 21篇 |
国内免费 | 12篇 |
专业分类
电工技术 | 12篇 |
综合类 | 15篇 |
化学工业 | 32篇 |
金属工艺 | 9篇 |
机械仪表 | 19篇 |
建筑科学 | 22篇 |
矿业工程 | 13篇 |
能源动力 | 4篇 |
轻工业 | 55篇 |
水利工程 | 4篇 |
石油天然气 | 6篇 |
武器工业 | 1篇 |
无线电 | 23篇 |
一般工业技术 | 20篇 |
冶金工业 | 3704篇 |
原子能技术 | 10篇 |
自动化技术 | 35篇 |
出版年
2023年 | 3篇 |
2022年 | 8篇 |
2021年 | 15篇 |
2020年 | 8篇 |
2019年 | 11篇 |
2018年 | 4篇 |
2017年 | 2篇 |
2016年 | 7篇 |
2015年 | 9篇 |
2014年 | 12篇 |
2013年 | 22篇 |
2012年 | 14篇 |
2011年 | 17篇 |
2010年 | 17篇 |
2009年 | 15篇 |
2008年 | 16篇 |
2007年 | 13篇 |
2006年 | 12篇 |
2005年 | 24篇 |
2004年 | 13篇 |
2003年 | 9篇 |
2002年 | 12篇 |
2001年 | 5篇 |
2000年 | 2篇 |
1999年 | 112篇 |
1998年 | 1217篇 |
1997年 | 706篇 |
1996年 | 411篇 |
1995年 | 248篇 |
1994年 | 194篇 |
1993年 | 210篇 |
1992年 | 38篇 |
1991年 | 24篇 |
1990年 | 42篇 |
1989年 | 36篇 |
1988年 | 47篇 |
1987年 | 37篇 |
1986年 | 35篇 |
1985年 | 35篇 |
1983年 | 4篇 |
1982年 | 14篇 |
1981年 | 19篇 |
1980年 | 25篇 |
1979年 | 2篇 |
1978年 | 12篇 |
1977年 | 82篇 |
1976年 | 148篇 |
1975年 | 11篇 |
1963年 | 1篇 |
1955年 | 3篇 |
排序方式: 共有3984条查询结果,搜索用时 31 毫秒
191.
KR Romines JK Morris WJ Howe PK Tomich MM Horng KT Chong RR Hinshaw DJ Anderson JW Strohbach SR Turner SA Mizsak 《Canadian Metallurgical Quarterly》1996,39(20):4125-4130
Previously, 3-substituted cycloalkylpyranones, such as 2d, have proven to be effective inhibitors of HIV protease. In an initial series of 3-(1-phenylpropyl) derivatives with various cycloalkyl ring sizes, the cyclooctyl analog was the most potent. We became interested in exploring the influence of other structural changes, such as substitution on the phenyl ring and saturation of the 5,6-double bond, on the cycloalkyl ring size structure-activity relationship (SAR). Saturation of the 5,6-double bond in the pyrone ring significantly impacts the SAR, altering the optimal ring size from eight to six. Substitution of a sulfonamide at the meta position of the phenyl ring dramatically increases the potency of these inhibitors, but it does not change the optimal ring size in either the cycloalkylpyranone or the cycloalkyldihydropyrone series. This work has led to the identification of compounds with superb binding affinity for the HIV protease (Ki values in the 10-50 pM range). In addition, the cycloalkyldihydropyrones showed excellent antiviral activity in cell culture, with ED50 values as low as 1 microM. 相似文献
192.
Infections of a species of Plasmodium (subgenus Giovannolaia) were diagnosed in 3 sandhill cranes (Grus canadensis) from north-central Florida. This parasite is close morphometrically to Plasmodium polare; this finding constitutes the first report of a species of Plasmodium from sandhill cranes in North America. 相似文献
193.
DL Persons RA Robinson PH Hsu SA Seelig TJ Borell LC Hartmann RB Jenkins 《Canadian Metallurgical Quarterly》1996,2(5):883-888
Fluorescence in situ hybridization was performed on touch preparations from 55 primary infiltrating ductal carcinomas of the breast to determine numeric chromosome abnormalities. The frequency of aneusomy, measured by both nondisomy and chromosomal gain, was determined for chromosomes X, 4, 6-12, 17, and 18 with the use of chromosome-specific, alpha-satellite DNA probes. The presence of chromosome-specific numeric abnormalities was correlated with established clinicopathological parameters, including tumor size, lymph node involvement, tumor grade, estrogen receptor level, and menopause status. In addition, a case-control study was performed to explore a possible association between chromosome-specific aneusomy and recurrence in lymph-node-negative patients. Although chromosomes 8 and 6 were most frequently aneusomic, numeric abnormalities of chromosomes 4 and 11 were most strongly associated with established prognostic factors. For chromosomes 4 and 11, strong associations were found with tumor involvement of lymph nodes and increased tumor size, along with a weaker association with tumor grade. In addition, numeric abnormalities of the following chromosomes were associated with the corresponding prognostic factors: chromosomes X, 7, and 12 with lymph node status; chromosomes 10, 17, and 6 with tumor size; and chromosomes 7, 12, 17, and X with tumor grade. No correlations were observed with estrogen receptor level or menopause status. In the case-control study performed on isolated nuclei of paraffin-embedded tissue from lymph node-negative breast cancer patients (19 cases and 19 controls), the gain of chromosome 4 was correlated with disease progression. These findings suggest that chromosome-specific aneusomy is associated with certain established prognostic factors and may be associated with disease progression. 相似文献
194.
Plasma L-arginine concentration, oxygenation index, and systemic blood pressure in premature infants
SA Zamora HJ Amin DD McMillan GH Fick JD Butzner HG Parsons RB Scott 《Canadian Metallurgical Quarterly》1998,26(7):1271-1276
OBJECTIVE: To determine the relationships between plasma L-arginine concentrations and the severity of respiratory distress syndrome (RDS) or systemic blood pressure in premature infants. DESIGN: Prospective, observational study. SETTING: Neonatal intensive care, tertiary referral hospital. SUBJECTS: Fifty-three premature infants. INTERVENTIONS: We measured arginine and nutritional intake, plasma arginine concentration, total amino acid concentrations, and blood pressure on days 3, 7, 14, and 21 of life. In 33 infants who received assisted ventilation, oxygenation index could be calculated to reflect the severity of RDS. The relationships between plasma arginine and oxygenation index or blood pressure were analyzed using multiple linear regression. MEASUREMENTS AND MAIN RESULTS: On day 3, plasma arginine concentrations were decreased compared with normal published values. Arginine concentrations increased with the day of life of measurement (p < .001) and with arginine intake (p < .001). After adjusting for arginine intake and day of life, an inverse relationship was found between oxygenation index and plasma arginine concentrations: (p = .025). No similar relationship was found between oxygenation index and the concentration of total amino acids. A weak positive relationship was found between plasma arginine concentration and systemic blood pressure. CONCLUSIONS: Increments in the oxygenation index, reflective of an increased severity of RDS, are associated with a decrease in plasma arginine concentration. This finding may reflect arginine consumption by the nitric oxide synthase pathway in the lungs of premature infants with RDS, or may be explained by increased arginine catabolism. The lack of a similar relationship between total plasma amino acids and oxygenation index supports the first interpretation. 相似文献
195.
We investigated the operation of a posttranslational protein translocation pathway to determine whether ions are excluded from the translocase during protein transport. The membrane capacitance during protein translocation across chloroplast thylakoid membranes was monitored via electric-field-indicating carotenoid electrochromic bandshift measurements. Evidence is presented that shows that the membrane ion conductance is not increased during the complete cycle of binding, transport, and substrate release by the DeltapH-dependent translocase; i.e., the membrane remains ion-tight during protein translocation. We further demonstrate that a synthetic targeting peptide that directs proteins across this membrane does not gate translocation pores. We conclude that protein transport across the thylakoid membrane does not compromise its ability to maintain ion gradients and is, thus, unlikely to affect its functions in energy transduction. 相似文献
196.
197.
198.
199.
200.
AD Argoudelis SA Mizsak L Baczynskyj RJ Wnuk 《Canadian Metallurgical Quarterly》1976,29(10):1117-1119